Gingival solitary chemosensory cells are immune sentinels for periodontitis

Solitary chemosensory cells (SCCs) expressing taste receptors reside in mucosal epithelia including the gingiva. Here the authors show that ablation of taste-sensing by SSCs leads to outgrowth of pathogenic oral bacteria and periodontitis, whereas bitter taste receptor stimulation promotes antimicro...

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Autores principales:	Xin Zheng, Marco Tizzano, Kevin Redding, Jinzhi He, Xian Peng, Peihua Jiang, Xin Xu, Xuedong Zhou, Robert F. Margolskee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8caffc7909634deb85a1fda385dca1cc
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spelling	oai:doaj.org-article:8caffc7909634deb85a1fda385dca1cc2021-12-02T14:35:37ZGingival solitary chemosensory cells are immune sentinels for periodontitis10.1038/s41467-019-12505-x2041-1723https://doaj.org/article/8caffc7909634deb85a1fda385dca1cc2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12505-xhttps://doaj.org/toc/2041-1723Solitary chemosensory cells (SCCs) expressing taste receptors reside in mucosal epithelia including the gingiva. Here the authors show that ablation of taste-sensing by SSCs leads to outgrowth of pathogenic oral bacteria and periodontitis, whereas bitter taste receptor stimulation promotes antimicrobial peptide production and ameliorates periodontitis.Xin ZhengMarco TizzanoKevin ReddingJinzhi HeXian PengPeihua JiangXin XuXuedong ZhouRobert F. MargolskeeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xin Zheng Marco Tizzano Kevin Redding Jinzhi He Xian Peng Peihua Jiang Xin Xu Xuedong Zhou Robert F. Margolskee Gingival solitary chemosensory cells are immune sentinels for periodontitis
description	Solitary chemosensory cells (SCCs) expressing taste receptors reside in mucosal epithelia including the gingiva. Here the authors show that ablation of taste-sensing by SSCs leads to outgrowth of pathogenic oral bacteria and periodontitis, whereas bitter taste receptor stimulation promotes antimicrobial peptide production and ameliorates periodontitis.
format	article
author	Xin Zheng Marco Tizzano Kevin Redding Jinzhi He Xian Peng Peihua Jiang Xin Xu Xuedong Zhou Robert F. Margolskee
author_facet	Xin Zheng Marco Tizzano Kevin Redding Jinzhi He Xian Peng Peihua Jiang Xin Xu Xuedong Zhou Robert F. Margolskee
author_sort	Xin Zheng
title	Gingival solitary chemosensory cells are immune sentinels for periodontitis
title_short	Gingival solitary chemosensory cells are immune sentinels for periodontitis
title_full	Gingival solitary chemosensory cells are immune sentinels for periodontitis
title_fullStr	Gingival solitary chemosensory cells are immune sentinels for periodontitis
title_full_unstemmed	Gingival solitary chemosensory cells are immune sentinels for periodontitis
title_sort	gingival solitary chemosensory cells are immune sentinels for periodontitis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8caffc7909634deb85a1fda385dca1cc
work_keys_str_mv	AT xinzheng gingivalsolitarychemosensorycellsareimmunesentinelsforperiodontitis AT marcotizzano gingivalsolitarychemosensorycellsareimmunesentinelsforperiodontitis AT kevinredding gingivalsolitarychemosensorycellsareimmunesentinelsforperiodontitis AT jinzhihe gingivalsolitarychemosensorycellsareimmunesentinelsforperiodontitis AT xianpeng gingivalsolitarychemosensorycellsareimmunesentinelsforperiodontitis AT peihuajiang gingivalsolitarychemosensorycellsareimmunesentinelsforperiodontitis AT xinxu gingivalsolitarychemosensorycellsareimmunesentinelsforperiodontitis AT xuedongzhou gingivalsolitarychemosensorycellsareimmunesentinelsforperiodontitis AT robertfmargolskee gingivalsolitarychemosensorycellsareimmunesentinelsforperiodontitis
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Gingival solitary chemosensory cells are immune sentinels for periodontitis

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