Passive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots

Guimiao Lin,1 Xiaomei Wang,1 Feng Yin,2 Ken-Tye Yong2 1The Engineering Lab of Synthetic Biology and Research Institute of Uropoiesis and Reproduction, School of Medicine, Shenzhen University, Shenzhen, People’s Republic of China; 2School of Electrical and Electronic Engineering, Nanyang T...

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Autores principales:	Lin G, Wang X, Yin F, Yong KT
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8cb018b46ea342b38c9f3e2717ea669d
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spelling	oai:doaj.org-article:8cb018b46ea342b38c9f3e2717ea669d2021-12-02T01:49:54ZPassive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots1178-2013https://doaj.org/article/8cb018b46ea342b38c9f3e2717ea669d2015-01-01T00:00:00Zhttp://www.dovepress.com/passive-tumor-targeting-and-imaging-by-using-mercaptosuccinic-acid-coa-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Guimiao Lin,1 Xiaomei Wang,1 Feng Yin,2 Ken-Tye Yong2 1The Engineering Lab of Synthetic Biology and Research Institute of Uropoiesis and Reproduction, School of Medicine, Shenzhen University, Shenzhen, People’s Republic of China; 2School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, Singapore Abstract: In this paper, we demonstrate the preparation of monodispersed quantum dots (QDs) as near-infrared (NIR) optical probes for in vivo pancreatic cancer targeting and imaging. The design of these luminescent probes involves functionalizing NIR QDs with ligand mercaptosuccinic acid (MSA), which targets the tumor site by enhanced permeability and retention effect. The colloidal and optical stability of the QDs can be maintained for >1 week. In vivo optical imaging studies in nude mice bearing pancreatic tumor show that the probes accumulate at tumor sites for >2.5 hours following intravenous injection of the functionalized NIR QDs. Tumor-labeling studies showed no evidence of harmful effects on the treated animals, even at a dose as high as ~50 mg/kg. These results demonstrate that the engineered MSA-functionalized QDs can serve as a diagnostic platform for early detection of cancer, as well as in image-guided precise surgical resection of tumors. Keywords: QDs, near-infrared, mercaptosuccinic acid, pancreatic cancer, tumor targetingLin GWang XYin FYong KTDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 335-345 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Lin G Wang X Yin F Yong KT Passive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots
description	Guimiao Lin,1 Xiaomei Wang,1 Feng Yin,2 Ken-Tye Yong2 1The Engineering Lab of Synthetic Biology and Research Institute of Uropoiesis and Reproduction, School of Medicine, Shenzhen University, Shenzhen, People’s Republic of China; 2School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, Singapore Abstract: In this paper, we demonstrate the preparation of monodispersed quantum dots (QDs) as near-infrared (NIR) optical probes for in vivo pancreatic cancer targeting and imaging. The design of these luminescent probes involves functionalizing NIR QDs with ligand mercaptosuccinic acid (MSA), which targets the tumor site by enhanced permeability and retention effect. The colloidal and optical stability of the QDs can be maintained for >1 week. In vivo optical imaging studies in nude mice bearing pancreatic tumor show that the probes accumulate at tumor sites for >2.5 hours following intravenous injection of the functionalized NIR QDs. Tumor-labeling studies showed no evidence of harmful effects on the treated animals, even at a dose as high as ~50 mg/kg. These results demonstrate that the engineered MSA-functionalized QDs can serve as a diagnostic platform for early detection of cancer, as well as in image-guided precise surgical resection of tumors. Keywords: QDs, near-infrared, mercaptosuccinic acid, pancreatic cancer, tumor targeting
format	article
author	Lin G Wang X Yin F Yong KT
author_facet	Lin G Wang X Yin F Yong KT
author_sort	Lin G
title	Passive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots
title_short	Passive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots
title_full	Passive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots
title_fullStr	Passive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots
title_full_unstemmed	Passive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots
title_sort	passive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/8cb018b46ea342b38c9f3e2717ea669d
work_keys_str_mv	AT ling passivetumortargetingandimagingbyusingmercaptosuccinicacidcoatednearinfraredquantumdots AT wangx passivetumortargetingandimagingbyusingmercaptosuccinicacidcoatednearinfraredquantumdots AT yinf passivetumortargetingandimagingbyusingmercaptosuccinicacidcoatednearinfraredquantumdots AT yongkt passivetumortargetingandimagingbyusingmercaptosuccinicacidcoatednearinfraredquantumdots
_version_	1718402852608540672

Passive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots

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