The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy

The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy

In a subset of patients with chronic lymphocytic leukemia (CLL) treated with targeted agents, such as ibrutinib, drug resistant subclones emerge. Here, the authors report on transcriptional changes in CLL patients treated with ibrutinib and identify early clonal shifts associated with evolution of r...

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Autores principales: Dan A. Landau, Clare Sun, Daniel Rosebrock, Sarah E. M. Herman, Joshua Fein, Mariela Sivina, Chingiz Underbayev, Delong Liu, Julia Hoellenriegel, Sarangan Ravichandran, Mohammed Z. H. Farooqui, Wandi Zhang, Carrie Cibulskis, Asaf Zviran, Donna S. Neuberg, Dimitri Livitz, Ivana Bozic, Ignaty Leshchiner, Gad Getz, Jan A. Burger, Adrian Wiestner, Catherine J. Wu
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/8cb0dbf9095d4ad38df29729f10e5da6
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spelling oai:doaj.org-article:8cb0dbf9095d4ad38df29729f10e5da62021-12-02T14:42:26ZThe evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy10.1038/s41467-017-02329-y2041-1723https://doaj.org/article/8cb0dbf9095d4ad38df29729f10e5da62017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02329-yhttps://doaj.org/toc/2041-1723In a subset of patients with chronic lymphocytic leukemia (CLL) treated with targeted agents, such as ibrutinib, drug resistant subclones emerge. Here, the authors report on transcriptional changes in CLL patients treated with ibrutinib and identify early clonal shifts associated with evolution of resistant clones.Dan A. LandauClare SunDaniel RosebrockSarah E. M. HermanJoshua FeinMariela SivinaChingiz UnderbayevDelong LiuJulia HoellenriegelSarangan RavichandranMohammed Z. H. FarooquiWandi ZhangCarrie CibulskisAsaf ZviranDonna S. NeubergDimitri LivitzIvana BozicIgnaty LeshchinerGad GetzJan A. BurgerAdrian WiestnerCatherine J. WuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Dan A. Landau
Clare Sun
Daniel Rosebrock
Sarah E. M. Herman
Joshua Fein
Mariela Sivina
Chingiz Underbayev
Delong Liu
Julia Hoellenriegel
Sarangan Ravichandran
Mohammed Z. H. Farooqui
Wandi Zhang
Carrie Cibulskis
Asaf Zviran
Donna S. Neuberg
Dimitri Livitz
Ivana Bozic
Ignaty Leshchiner
Gad Getz
Jan A. Burger
Adrian Wiestner
Catherine J. Wu
The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy
description In a subset of patients with chronic lymphocytic leukemia (CLL) treated with targeted agents, such as ibrutinib, drug resistant subclones emerge. Here, the authors report on transcriptional changes in CLL patients treated with ibrutinib and identify early clonal shifts associated with evolution of resistant clones.
format article
author Dan A. Landau
Clare Sun
Daniel Rosebrock
Sarah E. M. Herman
Joshua Fein
Mariela Sivina
Chingiz Underbayev
Delong Liu
Julia Hoellenriegel
Sarangan Ravichandran
Mohammed Z. H. Farooqui
Wandi Zhang
Carrie Cibulskis
Asaf Zviran
Donna S. Neuberg
Dimitri Livitz
Ivana Bozic
Ignaty Leshchiner
Gad Getz
Jan A. Burger
Adrian Wiestner
Catherine J. Wu
author_facet Dan A. Landau
Clare Sun
Daniel Rosebrock
Sarah E. M. Herman
Joshua Fein
Mariela Sivina
Chingiz Underbayev
Delong Liu
Julia Hoellenriegel
Sarangan Ravichandran
Mohammed Z. H. Farooqui
Wandi Zhang
Carrie Cibulskis
Asaf Zviran
Donna S. Neuberg
Dimitri Livitz
Ivana Bozic
Ignaty Leshchiner
Gad Getz
Jan A. Burger
Adrian Wiestner
Catherine J. Wu
author_sort Dan A. Landau
title The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy
title_short The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy
title_full The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy
title_fullStr The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy
title_full_unstemmed The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy
title_sort evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/8cb0dbf9095d4ad38df29729f10e5da6
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