Macrophage secretion of miR-106b-5p causes renin-dependent hypertension
Myeloid cells are involved in hypertension, but their exact role in renin-induced hypertension remains unclear. Here the authors show that impaired vitamin D signaling in myeloid cells causes hypertension via macrophage-specific miR-106b-5p secretion, which activates renin production in the kidney.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/8cb6617e470f45cba57e6e7e6d36d55d |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:8cb6617e470f45cba57e6e7e6d36d55d |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:8cb6617e470f45cba57e6e7e6d36d55d2021-12-02T18:48:11ZMacrophage secretion of miR-106b-5p causes renin-dependent hypertension10.1038/s41467-020-18538-x2041-1723https://doaj.org/article/8cb6617e470f45cba57e6e7e6d36d55d2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18538-xhttps://doaj.org/toc/2041-1723Myeloid cells are involved in hypertension, but their exact role in renin-induced hypertension remains unclear. Here the authors show that impaired vitamin D signaling in myeloid cells causes hypertension via macrophage-specific miR-106b-5p secretion, which activates renin production in the kidney.J. OhS. J. MatkovichA. E. RiekS. M. BindomJ. S. ShaoR. D. HeadR. A. BarveM. S. SandsG. CarmelietP. Osei-OwusuR. H. KnutsenH. ZhangK. J. BlumerC. G. NicholsR. P. MechamÁ BaldánB. A. BenitezM. L. Sequeira-LopezR. A. GomezC. Bernal-MizrachiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q J. Oh S. J. Matkovich A. E. Riek S. M. Bindom J. S. Shao R. D. Head R. A. Barve M. S. Sands G. Carmeliet P. Osei-Owusu R. H. Knutsen H. Zhang K. J. Blumer C. G. Nichols R. P. Mecham Á Baldán B. A. Benitez M. L. Sequeira-Lopez R. A. Gomez C. Bernal-Mizrachi Macrophage secretion of miR-106b-5p causes renin-dependent hypertension |
| description |
Myeloid cells are involved in hypertension, but their exact role in renin-induced hypertension remains unclear. Here the authors show that impaired vitamin D signaling in myeloid cells causes hypertension via macrophage-specific miR-106b-5p secretion, which activates renin production in the kidney. |
| format |
article |
| author |
J. Oh S. J. Matkovich A. E. Riek S. M. Bindom J. S. Shao R. D. Head R. A. Barve M. S. Sands G. Carmeliet P. Osei-Owusu R. H. Knutsen H. Zhang K. J. Blumer C. G. Nichols R. P. Mecham Á Baldán B. A. Benitez M. L. Sequeira-Lopez R. A. Gomez C. Bernal-Mizrachi |
| author_facet |
J. Oh S. J. Matkovich A. E. Riek S. M. Bindom J. S. Shao R. D. Head R. A. Barve M. S. Sands G. Carmeliet P. Osei-Owusu R. H. Knutsen H. Zhang K. J. Blumer C. G. Nichols R. P. Mecham Á Baldán B. A. Benitez M. L. Sequeira-Lopez R. A. Gomez C. Bernal-Mizrachi |
| author_sort |
J. Oh |
| title |
Macrophage secretion of miR-106b-5p causes renin-dependent hypertension |
| title_short |
Macrophage secretion of miR-106b-5p causes renin-dependent hypertension |
| title_full |
Macrophage secretion of miR-106b-5p causes renin-dependent hypertension |
| title_fullStr |
Macrophage secretion of miR-106b-5p causes renin-dependent hypertension |
| title_full_unstemmed |
Macrophage secretion of miR-106b-5p causes renin-dependent hypertension |
| title_sort |
macrophage secretion of mir-106b-5p causes renin-dependent hypertension |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/8cb6617e470f45cba57e6e7e6d36d55d |
| work_keys_str_mv |
AT joh macrophagesecretionofmir106b5pcausesrenindependenthypertension AT sjmatkovich macrophagesecretionofmir106b5pcausesrenindependenthypertension AT aeriek macrophagesecretionofmir106b5pcausesrenindependenthypertension AT smbindom macrophagesecretionofmir106b5pcausesrenindependenthypertension AT jsshao macrophagesecretionofmir106b5pcausesrenindependenthypertension AT rdhead macrophagesecretionofmir106b5pcausesrenindependenthypertension AT rabarve macrophagesecretionofmir106b5pcausesrenindependenthypertension AT mssands macrophagesecretionofmir106b5pcausesrenindependenthypertension AT gcarmeliet macrophagesecretionofmir106b5pcausesrenindependenthypertension AT poseiowusu macrophagesecretionofmir106b5pcausesrenindependenthypertension AT rhknutsen macrophagesecretionofmir106b5pcausesrenindependenthypertension AT hzhang macrophagesecretionofmir106b5pcausesrenindependenthypertension AT kjblumer macrophagesecretionofmir106b5pcausesrenindependenthypertension AT cgnichols macrophagesecretionofmir106b5pcausesrenindependenthypertension AT rpmecham macrophagesecretionofmir106b5pcausesrenindependenthypertension AT abaldan macrophagesecretionofmir106b5pcausesrenindependenthypertension AT babenitez macrophagesecretionofmir106b5pcausesrenindependenthypertension AT mlsequeiralopez macrophagesecretionofmir106b5pcausesrenindependenthypertension AT ragomez macrophagesecretionofmir106b5pcausesrenindependenthypertension AT cbernalmizrachi macrophagesecretionofmir106b5pcausesrenindependenthypertension |
| _version_ |
1718377637329502208 |