AMBRA1 attenuates the proliferation of uveal melanoma cells

Uveal melanoma (UVM) is the most common primary intraocular malignancy in adults with high metastasis rates. D-type cyclins (CCNDs) are central regulators of the cell division cycle and are among the most frequently deregulated therapeutic targets in human cancer. Recently, the E3 ligase adaptor, au...

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Autores principales:	Zhao Binbin, Yang Yun, Cun Biyun, Chen Ping
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	uveal melanoma ambra1 ccnd1 ubiquitination Medicine R
Acceso en línea:	https://doaj.org/article/8cb6d8d05b184cc6addf1024a6be9d09
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spelling	oai:doaj.org-article:8cb6d8d05b184cc6addf1024a6be9d092021-12-05T14:10:55ZAMBRA1 attenuates the proliferation of uveal melanoma cells2391-546310.1515/med-2021-0386https://doaj.org/article/8cb6d8d05b184cc6addf1024a6be9d092021-11-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0386https://doaj.org/toc/2391-5463Uveal melanoma (UVM) is the most common primary intraocular malignancy in adults with high metastasis rates. D-type cyclins (CCNDs) are central regulators of the cell division cycle and are among the most frequently deregulated therapeutic targets in human cancer. Recently, the E3 ligase adaptor, autophagy and beclin 1 regulator 1 (AMBRA1), was reported to regulate the stability of CCNDs, including CCND1, but its role in UVM has not been demonstrated. AMBRA1 is lowly expressed in UVM cells, and the ablation of AMBRA1 promotes the proliferation of 92.1 and OMM1 cells, whereas ectopically expressing AMBRA1 attenuates the proliferation of UVM cells. Further studies found that AMBRA1 promotes the ubiquitination and degradation of CCND1, and AMBRA1 regulates the proliferation of UVM cells in a CCND1-dependent manner. Thus, this study suggests that AMBRA1 serves as an important tumor suppressor by limiting UVM cell growth.Zhao BinbinYang YunCun BiyunChen PingDe Gruyterarticleuveal melanomaambra1ccnd1ubiquitinationMedicineRENOpen Medicine, Vol 17, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	uveal melanoma ambra1 ccnd1 ubiquitination Medicine R
spellingShingle	uveal melanoma ambra1 ccnd1 ubiquitination Medicine R Zhao Binbin Yang Yun Cun Biyun Chen Ping AMBRA1 attenuates the proliferation of uveal melanoma cells
description	Uveal melanoma (UVM) is the most common primary intraocular malignancy in adults with high metastasis rates. D-type cyclins (CCNDs) are central regulators of the cell division cycle and are among the most frequently deregulated therapeutic targets in human cancer. Recently, the E3 ligase adaptor, autophagy and beclin 1 regulator 1 (AMBRA1), was reported to regulate the stability of CCNDs, including CCND1, but its role in UVM has not been demonstrated. AMBRA1 is lowly expressed in UVM cells, and the ablation of AMBRA1 promotes the proliferation of 92.1 and OMM1 cells, whereas ectopically expressing AMBRA1 attenuates the proliferation of UVM cells. Further studies found that AMBRA1 promotes the ubiquitination and degradation of CCND1, and AMBRA1 regulates the proliferation of UVM cells in a CCND1-dependent manner. Thus, this study suggests that AMBRA1 serves as an important tumor suppressor by limiting UVM cell growth.
format	article
author	Zhao Binbin Yang Yun Cun Biyun Chen Ping
author_facet	Zhao Binbin Yang Yun Cun Biyun Chen Ping
author_sort	Zhao Binbin
title	AMBRA1 attenuates the proliferation of uveal melanoma cells
title_short	AMBRA1 attenuates the proliferation of uveal melanoma cells
title_full	AMBRA1 attenuates the proliferation of uveal melanoma cells
title_fullStr	AMBRA1 attenuates the proliferation of uveal melanoma cells
title_full_unstemmed	AMBRA1 attenuates the proliferation of uveal melanoma cells
title_sort	ambra1 attenuates the proliferation of uveal melanoma cells
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/8cb6d8d05b184cc6addf1024a6be9d09
work_keys_str_mv	AT zhaobinbin ambra1attenuatestheproliferationofuvealmelanomacells AT yangyun ambra1attenuatestheproliferationofuvealmelanomacells AT cunbiyun ambra1attenuatestheproliferationofuvealmelanomacells AT chenping ambra1attenuatestheproliferationofuvealmelanomacells
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AMBRA1 attenuates the proliferation of uveal melanoma cells

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