Association between the rs1042522 polymorphism in TP53 and prostate cancer risk: An updated meta-analysis

Association between the rs1042522 polymorphism in TP53 and prostate cancer risk: An updated meta-analysis

Objective: The proposal of the present study was to investigate whether the TP53 rs1042522 polymorphism confers susceptibility to prostate cancer (PCa), by performing an updated meta-analysis. Methods: Eligible publications investigating the association between the TP53 rs1042522 polymorphism and PC...

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Autores principales: Song Fan, Zong-Yao Hao, Meng Zhang, Chao-Zhao Liang
Formato: article
Lenguaje:EN
Publicado: KeAi Communications Co., Ltd. 2017
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Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/8cb703adb1514733870d26f53f53777c
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spelling oai:doaj.org-article:8cb703adb1514733870d26f53f53777c2021-12-02T12:52:11ZAssociation between the rs1042522 polymorphism in TP53 and prostate cancer risk: An updated meta-analysis2095-882X10.1016/j.cdtm.2017.04.001https://doaj.org/article/8cb703adb1514733870d26f53f53777c2017-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X1630127Xhttps://doaj.org/toc/2095-882XObjective: The proposal of the present study was to investigate whether the TP53 rs1042522 polymorphism confers susceptibility to prostate cancer (PCa), by performing an updated meta-analysis. Methods: Eligible publications investigating the association between the TP53 rs1042522 polymorphism and PCa susceptibility were selected from PubMed, Google Scholar, and Web of Science. We used STATA 12.0 software to conduct the analyses. Odds ratio (OR) with 95% confidence interval (CI) was calculated. Results: A total of 17 caseâcontrol studies were retrieved reporting a total of 2683 cases and 2981 controls. However, no significant association was uncovered between the TP53 rs1042522 polymorphism and PCa susceptibility in the overall population under the five genetic models. In the stratification analysis by source of control, an increased susceptibility to PCa was identified in the population-based (P-B) group (CG vs. GG: OR = 1.48, 95% CI: 1.24â1.77, P < 0.01; CC/CG vs. GG: OR = 1.32, 95% CI: 1.12â1.57, P < 0.01), whereas a decreased susceptibility was uncovered in the hospital-based (H-B) group (CG vs. GG: OR = 0.67, 95% CI: 0.46â0.96, P = 0.03; CC/CG vs. GG: OR = 0.67, 95% CI: 0.46â0.99, P = 0.04) under heterozygous and dominant model. Conclusion: This study did not find an association between the TP53 rs1042522 polymorphism and PCa susceptibility in the overall population and corresponding subgroup analyses except in the stratification analysis by source of control. The results suggest that the TP53 rs1042522 polymorphism is not a risk factor for PCa. Keywords: TP53, rs1042522, Polymorphism, Prostate cancer, Meta-analysisSong FanZong-Yao HaoMeng ZhangChao-Zhao LiangKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 3, Iss 2, Pp 95-104 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Song Fan
Zong-Yao Hao
Meng Zhang
Chao-Zhao Liang
Association between the rs1042522 polymorphism in TP53 and prostate cancer risk: An updated meta-analysis
description Objective: The proposal of the present study was to investigate whether the TP53 rs1042522 polymorphism confers susceptibility to prostate cancer (PCa), by performing an updated meta-analysis. Methods: Eligible publications investigating the association between the TP53 rs1042522 polymorphism and PCa susceptibility were selected from PubMed, Google Scholar, and Web of Science. We used STATA 12.0 software to conduct the analyses. Odds ratio (OR) with 95% confidence interval (CI) was calculated. Results: A total of 17 caseâcontrol studies were retrieved reporting a total of 2683 cases and 2981 controls. However, no significant association was uncovered between the TP53 rs1042522 polymorphism and PCa susceptibility in the overall population under the five genetic models. In the stratification analysis by source of control, an increased susceptibility to PCa was identified in the population-based (P-B) group (CG vs. GG: OR = 1.48, 95% CI: 1.24â1.77, P < 0.01; CC/CG vs. GG: OR = 1.32, 95% CI: 1.12â1.57, P < 0.01), whereas a decreased susceptibility was uncovered in the hospital-based (H-B) group (CG vs. GG: OR = 0.67, 95% CI: 0.46â0.96, P = 0.03; CC/CG vs. GG: OR = 0.67, 95% CI: 0.46â0.99, P = 0.04) under heterozygous and dominant model. Conclusion: This study did not find an association between the TP53 rs1042522 polymorphism and PCa susceptibility in the overall population and corresponding subgroup analyses except in the stratification analysis by source of control. The results suggest that the TP53 rs1042522 polymorphism is not a risk factor for PCa. Keywords: TP53, rs1042522, Polymorphism, Prostate cancer, Meta-analysis
format article
author Song Fan
Zong-Yao Hao
Meng Zhang
Chao-Zhao Liang
author_facet Song Fan
Zong-Yao Hao
Meng Zhang
Chao-Zhao Liang
author_sort Song Fan
title Association between the rs1042522 polymorphism in TP53 and prostate cancer risk: An updated meta-analysis
title_short Association between the rs1042522 polymorphism in TP53 and prostate cancer risk: An updated meta-analysis
title_full Association between the rs1042522 polymorphism in TP53 and prostate cancer risk: An updated meta-analysis
title_fullStr Association between the rs1042522 polymorphism in TP53 and prostate cancer risk: An updated meta-analysis
title_full_unstemmed Association between the rs1042522 polymorphism in TP53 and prostate cancer risk: An updated meta-analysis
title_sort association between the rs1042522 polymorphism in tp53 and prostate cancer risk: an updated meta-analysis
publisher KeAi Communications Co., Ltd.
publishDate 2017
url https://doaj.org/article/8cb703adb1514733870d26f53f53777c
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AT mengzhang associationbetweenthers1042522polymorphismintp53andprostatecancerriskanupdatedmetaanalysis
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