CRISPR based editing of SIV proviral DNA in ART treated non-human primates

Removal of integrated HIV DNA remains a roadblock for HIV cure. Here, Mancuso et al. show that intravenous administration of an adeno-associated virus-based CRISPR/Cas9 gene editing construct to SIV-infected macaques results in excision of integrated proviral DNA from infected blood cells and tissue...

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Autores principales:	Pietro Mancuso, Chen Chen, Rafal Kaminski, Jennifer Gordon, Shuren Liao, Jake A. Robinson, Mandy D. Smith, Hong Liu, Ilker K. Sariyer, Rahsan Sariyer, Tiffany A. Peterson, Martina Donadoni, Jaclyn B. Williams, Summer Siddiqui, Bruce A. Bunnell, Binhua Ling, Andrew G. MacLean, Tricia H. Burdo, Kamel Khalili
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8cbe71bbcb2e47d19d5219446802dbe4
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spelling	oai:doaj.org-article:8cbe71bbcb2e47d19d5219446802dbe42021-12-02T16:49:48ZCRISPR based editing of SIV proviral DNA in ART treated non-human primates10.1038/s41467-020-19821-72041-1723https://doaj.org/article/8cbe71bbcb2e47d19d5219446802dbe42020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19821-7https://doaj.org/toc/2041-1723Removal of integrated HIV DNA remains a roadblock for HIV cure. Here, Mancuso et al. show that intravenous administration of an adeno-associated virus-based CRISPR/Cas9 gene editing construct to SIV-infected macaques results in excision of integrated proviral DNA from infected blood cells and tissues known to be viral reservoirs.Pietro MancusoChen ChenRafal KaminskiJennifer GordonShuren LiaoJake A. RobinsonMandy D. SmithHong LiuIlker K. SariyerRahsan SariyerTiffany A. PetersonMartina DonadoniJaclyn B. WilliamsSummer SiddiquiBruce A. BunnellBinhua LingAndrew G. MacLeanTricia H. BurdoKamel KhaliliNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pietro Mancuso Chen Chen Rafal Kaminski Jennifer Gordon Shuren Liao Jake A. Robinson Mandy D. Smith Hong Liu Ilker K. Sariyer Rahsan Sariyer Tiffany A. Peterson Martina Donadoni Jaclyn B. Williams Summer Siddiqui Bruce A. Bunnell Binhua Ling Andrew G. MacLean Tricia H. Burdo Kamel Khalili CRISPR based editing of SIV proviral DNA in ART treated non-human primates
description	Removal of integrated HIV DNA remains a roadblock for HIV cure. Here, Mancuso et al. show that intravenous administration of an adeno-associated virus-based CRISPR/Cas9 gene editing construct to SIV-infected macaques results in excision of integrated proviral DNA from infected blood cells and tissues known to be viral reservoirs.
format	article
author	Pietro Mancuso Chen Chen Rafal Kaminski Jennifer Gordon Shuren Liao Jake A. Robinson Mandy D. Smith Hong Liu Ilker K. Sariyer Rahsan Sariyer Tiffany A. Peterson Martina Donadoni Jaclyn B. Williams Summer Siddiqui Bruce A. Bunnell Binhua Ling Andrew G. MacLean Tricia H. Burdo Kamel Khalili
author_facet	Pietro Mancuso Chen Chen Rafal Kaminski Jennifer Gordon Shuren Liao Jake A. Robinson Mandy D. Smith Hong Liu Ilker K. Sariyer Rahsan Sariyer Tiffany A. Peterson Martina Donadoni Jaclyn B. Williams Summer Siddiqui Bruce A. Bunnell Binhua Ling Andrew G. MacLean Tricia H. Burdo Kamel Khalili
author_sort	Pietro Mancuso
title	CRISPR based editing of SIV proviral DNA in ART treated non-human primates
title_short	CRISPR based editing of SIV proviral DNA in ART treated non-human primates
title_full	CRISPR based editing of SIV proviral DNA in ART treated non-human primates
title_fullStr	CRISPR based editing of SIV proviral DNA in ART treated non-human primates
title_full_unstemmed	CRISPR based editing of SIV proviral DNA in ART treated non-human primates
title_sort	crispr based editing of siv proviral dna in art treated non-human primates
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8cbe71bbcb2e47d19d5219446802dbe4
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CRISPR based editing of SIV proviral DNA in ART treated non-human primates

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