Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites
How autophagy supports tumor cell metabolism is not fully clear. Here, the authors show that autophagy regulates lipid availability to support mitochondrial oxidative metabolism through mitochondria-endoplasmic reticulum contact sites, necessary for cell proliferation in AML.
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Nature Portfolio
2020
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oai:doaj.org-article:8cc02f2742d84833a052afbcc115d3a32021-12-02T18:50:44ZAutophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites10.1038/s41467-020-17882-22041-1723https://doaj.org/article/8cc02f2742d84833a052afbcc115d3a32020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17882-2https://doaj.org/toc/2041-1723How autophagy supports tumor cell metabolism is not fully clear. Here, the authors show that autophagy regulates lipid availability to support mitochondrial oxidative metabolism through mitochondria-endoplasmic reticulum contact sites, necessary for cell proliferation in AML.Claudie BoscNicolas BroinMarjorie FanjulEstelle SalandThomas FargeCharly CourdyAurélie BatutRawand MasoudClément LarrueSarah SkuliNicolas EspagnolleJean-Christophe PagèsAlice CarrierFrédéric BostJustine Bertrand-MichelJérôme TamburiniChristian RécherSarah BertoliVéronique Mansat-De MasStéphane ManentiJean-Emmanuel SarryCarine JoffreNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Claudie Bosc Nicolas Broin Marjorie Fanjul Estelle Saland Thomas Farge Charly Courdy Aurélie Batut Rawand Masoud Clément Larrue Sarah Skuli Nicolas Espagnolle Jean-Christophe Pagès Alice Carrier Frédéric Bost Justine Bertrand-Michel Jérôme Tamburini Christian Récher Sarah Bertoli Véronique Mansat-De Mas Stéphane Manenti Jean-Emmanuel Sarry Carine Joffre Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites |
| description |
How autophagy supports tumor cell metabolism is not fully clear. Here, the authors show that autophagy regulates lipid availability to support mitochondrial oxidative metabolism through mitochondria-endoplasmic reticulum contact sites, necessary for cell proliferation in AML. |
| format |
article |
| author |
Claudie Bosc Nicolas Broin Marjorie Fanjul Estelle Saland Thomas Farge Charly Courdy Aurélie Batut Rawand Masoud Clément Larrue Sarah Skuli Nicolas Espagnolle Jean-Christophe Pagès Alice Carrier Frédéric Bost Justine Bertrand-Michel Jérôme Tamburini Christian Récher Sarah Bertoli Véronique Mansat-De Mas Stéphane Manenti Jean-Emmanuel Sarry Carine Joffre |
| author_facet |
Claudie Bosc Nicolas Broin Marjorie Fanjul Estelle Saland Thomas Farge Charly Courdy Aurélie Batut Rawand Masoud Clément Larrue Sarah Skuli Nicolas Espagnolle Jean-Christophe Pagès Alice Carrier Frédéric Bost Justine Bertrand-Michel Jérôme Tamburini Christian Récher Sarah Bertoli Véronique Mansat-De Mas Stéphane Manenti Jean-Emmanuel Sarry Carine Joffre |
| author_sort |
Claudie Bosc |
| title |
Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites |
| title_short |
Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites |
| title_full |
Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites |
| title_fullStr |
Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites |
| title_full_unstemmed |
Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites |
| title_sort |
autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/8cc02f2742d84833a052afbcc115d3a3 |
| work_keys_str_mv |
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1718377517222461440 |