Increased number of neurons in the cervical spinal cord of aged female rats.

In the brain, specific signaling pathways localized in highly organized regions called niches allow the persistence of a pool of stem and progenitor cells that generate new neurons in adulthood. Much less is known about the spinal cord where a sustained adult neurogenesis is not observed. Moreover,...

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Autores principales:	Enrique L Portiansky, Fabian Nishida, Claudio G Barbeito, Eduardo J Gimeno, Rodolfo G Goya
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8cc2c2b771d74913b07d0e1c8a430b02
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spelling	oai:doaj.org-article:8cc2c2b771d74913b07d0e1c8a430b022021-11-18T06:49:50ZIncreased number of neurons in the cervical spinal cord of aged female rats.1932-620310.1371/journal.pone.0022537https://doaj.org/article/8cc2c2b771d74913b07d0e1c8a430b022011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21799890/?tool=EBIhttps://doaj.org/toc/1932-6203In the brain, specific signaling pathways localized in highly organized regions called niches allow the persistence of a pool of stem and progenitor cells that generate new neurons in adulthood. Much less is known about the spinal cord where a sustained adult neurogenesis is not observed. Moreover, there is scarce information concerning cell proliferation in the adult mammalian spinal cord and virtually none in aging animals or humans. We performed a comparative morphometric and immunofluorescence study of the entire cervical region (C1-C8) in young (5 mo.) and aged (30 mo.) female rats. Serum prolactin (PRL), a neurogenic hormone, was also measured. Gross anatomy showed a significant age-related increase in size of all of the cervical segments. Morphometric analysis of cresyl violet stained segments also showed a significant increase in the area occupied by the gray matter of some cervical segments of aged rats. The most interesting finding was that both the total area occupied by neurons and the number of neurons increased significantly with age, the latter increase ranging from 16% (C6) to 34% (C2). Taking the total number of cervical neurons the age-related increase ranged from 19% (C6) to 51% (C3), C3 being the segment that grew most in length in the aged animals. Some bromodeoxyuridine positive-neuron specific enolase negative (BrdU(+)-NSE(-)) cells were observed and, occasionally, double positive (BrdU(+)-NSE(+)) cells were detected in some cervical segments of both young and aged rats groups. As expected, serum PRL increased markedly with age. We propose that in the cervical spinal cord of female rats, both maturation of pre-existing neuroblasts and/or possible neurogenesis occur during the entire life span, in a process in which PRL may play a role.Enrique L PortianskyFabian NishidaClaudio G BarbeitoEduardo J GimenoRodolfo G GoyaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e22537 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Enrique L Portiansky Fabian Nishida Claudio G Barbeito Eduardo J Gimeno Rodolfo G Goya Increased number of neurons in the cervical spinal cord of aged female rats.
description	In the brain, specific signaling pathways localized in highly organized regions called niches allow the persistence of a pool of stem and progenitor cells that generate new neurons in adulthood. Much less is known about the spinal cord where a sustained adult neurogenesis is not observed. Moreover, there is scarce information concerning cell proliferation in the adult mammalian spinal cord and virtually none in aging animals or humans. We performed a comparative morphometric and immunofluorescence study of the entire cervical region (C1-C8) in young (5 mo.) and aged (30 mo.) female rats. Serum prolactin (PRL), a neurogenic hormone, was also measured. Gross anatomy showed a significant age-related increase in size of all of the cervical segments. Morphometric analysis of cresyl violet stained segments also showed a significant increase in the area occupied by the gray matter of some cervical segments of aged rats. The most interesting finding was that both the total area occupied by neurons and the number of neurons increased significantly with age, the latter increase ranging from 16% (C6) to 34% (C2). Taking the total number of cervical neurons the age-related increase ranged from 19% (C6) to 51% (C3), C3 being the segment that grew most in length in the aged animals. Some bromodeoxyuridine positive-neuron specific enolase negative (BrdU(+)-NSE(-)) cells were observed and, occasionally, double positive (BrdU(+)-NSE(+)) cells were detected in some cervical segments of both young and aged rats groups. As expected, serum PRL increased markedly with age. We propose that in the cervical spinal cord of female rats, both maturation of pre-existing neuroblasts and/or possible neurogenesis occur during the entire life span, in a process in which PRL may play a role.
format	article
author	Enrique L Portiansky Fabian Nishida Claudio G Barbeito Eduardo J Gimeno Rodolfo G Goya
author_facet	Enrique L Portiansky Fabian Nishida Claudio G Barbeito Eduardo J Gimeno Rodolfo G Goya
author_sort	Enrique L Portiansky
title	Increased number of neurons in the cervical spinal cord of aged female rats.
title_short	Increased number of neurons in the cervical spinal cord of aged female rats.
title_full	Increased number of neurons in the cervical spinal cord of aged female rats.
title_fullStr	Increased number of neurons in the cervical spinal cord of aged female rats.
title_full_unstemmed	Increased number of neurons in the cervical spinal cord of aged female rats.
title_sort	increased number of neurons in the cervical spinal cord of aged female rats.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/8cc2c2b771d74913b07d0e1c8a430b02
work_keys_str_mv	AT enriquelportiansky increasednumberofneuronsinthecervicalspinalcordofagedfemalerats AT fabiannishida increasednumberofneuronsinthecervicalspinalcordofagedfemalerats AT claudiogbarbeito increasednumberofneuronsinthecervicalspinalcordofagedfemalerats AT eduardojgimeno increasednumberofneuronsinthecervicalspinalcordofagedfemalerats AT rodolfoggoya increasednumberofneuronsinthecervicalspinalcordofagedfemalerats
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Increased number of neurons in the cervical spinal cord of aged female rats.

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