Design of ultra-swollen lipidic mesophases for the crystallization of membrane proteins with large extracellular domains

In meso crystallization of membrane proteins is limited to proteins with small extracellular domains (ECDs). Here, authors combine monoacylglycerols and phospholipids to design stable ultra-swollen bicontinuous cubic phases that allow in meso crystallization of proteins with large ECDs.

Guardado en:

Detalles Bibliográficos
Autores principales:	Alexandru Zabara, Josephine Tse Yin Chong, Isabelle Martiel, Laura Stark, Brett A. Cromer, Chiara Speziale, Calum John Drummond, Raffaele Mezzenga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8cca585f27924bc6bba1d6ae8151e364
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8cca585f27924bc6bba1d6ae8151e364
record_format	dspace
spelling	oai:doaj.org-article:8cca585f27924bc6bba1d6ae8151e3642021-12-02T14:40:09ZDesign of ultra-swollen lipidic mesophases for the crystallization of membrane proteins with large extracellular domains10.1038/s41467-018-02996-52041-1723https://doaj.org/article/8cca585f27924bc6bba1d6ae8151e3642018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02996-5https://doaj.org/toc/2041-1723In meso crystallization of membrane proteins is limited to proteins with small extracellular domains (ECDs). Here, authors combine monoacylglycerols and phospholipids to design stable ultra-swollen bicontinuous cubic phases that allow in meso crystallization of proteins with large ECDs.Alexandru ZabaraJosephine Tse Yin ChongIsabelle MartielLaura StarkBrett A. CromerChiara SpezialeCalum John DrummondRaffaele MezzengaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexandru Zabara Josephine Tse Yin Chong Isabelle Martiel Laura Stark Brett A. Cromer Chiara Speziale Calum John Drummond Raffaele Mezzenga Design of ultra-swollen lipidic mesophases for the crystallization of membrane proteins with large extracellular domains
description	In meso crystallization of membrane proteins is limited to proteins with small extracellular domains (ECDs). Here, authors combine monoacylglycerols and phospholipids to design stable ultra-swollen bicontinuous cubic phases that allow in meso crystallization of proteins with large ECDs.
format	article
author	Alexandru Zabara Josephine Tse Yin Chong Isabelle Martiel Laura Stark Brett A. Cromer Chiara Speziale Calum John Drummond Raffaele Mezzenga
author_facet	Alexandru Zabara Josephine Tse Yin Chong Isabelle Martiel Laura Stark Brett A. Cromer Chiara Speziale Calum John Drummond Raffaele Mezzenga
author_sort	Alexandru Zabara
title	Design of ultra-swollen lipidic mesophases for the crystallization of membrane proteins with large extracellular domains
title_short	Design of ultra-swollen lipidic mesophases for the crystallization of membrane proteins with large extracellular domains
title_full	Design of ultra-swollen lipidic mesophases for the crystallization of membrane proteins with large extracellular domains
title_fullStr	Design of ultra-swollen lipidic mesophases for the crystallization of membrane proteins with large extracellular domains
title_full_unstemmed	Design of ultra-swollen lipidic mesophases for the crystallization of membrane proteins with large extracellular domains
title_sort	design of ultra-swollen lipidic mesophases for the crystallization of membrane proteins with large extracellular domains
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8cca585f27924bc6bba1d6ae8151e364
work_keys_str_mv	AT alexandruzabara designofultraswollenlipidicmesophasesforthecrystallizationofmembraneproteinswithlargeextracellulardomains AT josephinetseyinchong designofultraswollenlipidicmesophasesforthecrystallizationofmembraneproteinswithlargeextracellulardomains AT isabellemartiel designofultraswollenlipidicmesophasesforthecrystallizationofmembraneproteinswithlargeextracellulardomains AT laurastark designofultraswollenlipidicmesophasesforthecrystallizationofmembraneproteinswithlargeextracellulardomains AT brettacromer designofultraswollenlipidicmesophasesforthecrystallizationofmembraneproteinswithlargeextracellulardomains AT chiaraspeziale designofultraswollenlipidicmesophasesforthecrystallizationofmembraneproteinswithlargeextracellulardomains AT calumjohndrummond designofultraswollenlipidicmesophasesforthecrystallizationofmembraneproteinswithlargeextracellulardomains AT raffaelemezzenga designofultraswollenlipidicmesophasesforthecrystallizationofmembraneproteinswithlargeextracellulardomains
_version_	1718390429159784448

Design of ultra-swollen lipidic mesophases for the crystallization of membrane proteins with large extracellular domains

Ejemplares similares