Genetically predicted education attainment in relation to somatic and mental health

Abstract A deeper understanding of the causal links from education level to health outcomes may shed a light for disease prevention. In the present Mendelian randomization study, we found that genetically higher education level was associated with lower risk of major mental disorders and most somati...

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Autores principales:	Shuai Yuan, Ying Xiong, Madeleine Michaëlsson, Karl Michaëlsson, Susanna C. Larsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8ccfa8bdd9ae4e7689210ea8cf46e748
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spelling	oai:doaj.org-article:8ccfa8bdd9ae4e7689210ea8cf46e7482021-12-02T11:02:38ZGenetically predicted education attainment in relation to somatic and mental health10.1038/s41598-021-83801-02045-2322https://doaj.org/article/8ccfa8bdd9ae4e7689210ea8cf46e7482021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83801-0https://doaj.org/toc/2045-2322Abstract A deeper understanding of the causal links from education level to health outcomes may shed a light for disease prevention. In the present Mendelian randomization study, we found that genetically higher education level was associated with lower risk of major mental disorders and most somatic diseases, independent of intelligence. Higher education level adjusted for intelligence was associated with lower risk of suicide attempts, insomnia, major depressive disorder, heart failure, stroke, coronary artery disease, lung cancer, breast cancer, type 2 diabetes and rheumatoid arthritis but with higher risk of obsessive–compulsive disorder, anorexia nervosa, anxiety, bipolar disorder and prostate cancer. Higher education level was associated with reduced obesity and smoking, which mediated quite an extent of the associations between education level and health outcomes. These findings emphasize the importance of education to reduce the burden of common diseases.Shuai YuanYing XiongMadeleine MichaëlssonKarl MichaëlssonSusanna C. LarssonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shuai Yuan Ying Xiong Madeleine Michaëlsson Karl Michaëlsson Susanna C. Larsson Genetically predicted education attainment in relation to somatic and mental health
description	Abstract A deeper understanding of the causal links from education level to health outcomes may shed a light for disease prevention. In the present Mendelian randomization study, we found that genetically higher education level was associated with lower risk of major mental disorders and most somatic diseases, independent of intelligence. Higher education level adjusted for intelligence was associated with lower risk of suicide attempts, insomnia, major depressive disorder, heart failure, stroke, coronary artery disease, lung cancer, breast cancer, type 2 diabetes and rheumatoid arthritis but with higher risk of obsessive–compulsive disorder, anorexia nervosa, anxiety, bipolar disorder and prostate cancer. Higher education level was associated with reduced obesity and smoking, which mediated quite an extent of the associations between education level and health outcomes. These findings emphasize the importance of education to reduce the burden of common diseases.
format	article
author	Shuai Yuan Ying Xiong Madeleine Michaëlsson Karl Michaëlsson Susanna C. Larsson
author_facet	Shuai Yuan Ying Xiong Madeleine Michaëlsson Karl Michaëlsson Susanna C. Larsson
author_sort	Shuai Yuan
title	Genetically predicted education attainment in relation to somatic and mental health
title_short	Genetically predicted education attainment in relation to somatic and mental health
title_full	Genetically predicted education attainment in relation to somatic and mental health
title_fullStr	Genetically predicted education attainment in relation to somatic and mental health
title_full_unstemmed	Genetically predicted education attainment in relation to somatic and mental health
title_sort	genetically predicted education attainment in relation to somatic and mental health
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8ccfa8bdd9ae4e7689210ea8cf46e748
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Genetically predicted education attainment in relation to somatic and mental health

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