Hypolipidemic and Antioxidant Effects of <i>Guishe</i> Extract from <i>Agave lechuguilla,</i> a Mexican Plant with Biotechnological Potential, on Streptozotocin-Induced Diabetic Male Rats

In the present study, we used a by-product from <i>Agave lechuguilla</i> (<i>guishe</i>) to test its antidiabetic effect, hypolipidemic activity, and capacity to mitigate the oxidative stress in kidney mitochondria from streptozotocin-induced diabetic rats. Orally, a crude aq...

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Autores principales: Edgar R. Esquivel-Gutiérrez, Salvador Manzo-Avalos, Donovan J. Peña-Montes, Alfredo Saavedra-Molina, Zoé P. Morreeuw, Ana G. Reyes
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spelling oai:doaj.org-article:8ccfefaab1594da98d0ec49d7f5e924e2021-11-25T18:47:02ZHypolipidemic and Antioxidant Effects of <i>Guishe</i> Extract from <i>Agave lechuguilla,</i> a Mexican Plant with Biotechnological Potential, on Streptozotocin-Induced Diabetic Male Rats10.3390/plants101124922223-7747https://doaj.org/article/8ccfefaab1594da98d0ec49d7f5e924e2021-11-01T00:00:00Zhttps://www.mdpi.com/2223-7747/10/11/2492https://doaj.org/toc/2223-7747In the present study, we used a by-product from <i>Agave lechuguilla</i> (<i>guishe</i>) to test its antidiabetic effect, hypolipidemic activity, and capacity to mitigate the oxidative stress in kidney mitochondria from streptozotocin-induced diabetic rats. Orally, a crude aqueous extract from lyophilized <i>guishe</i> was administered over 5 weeks at different doses. Blood glucose and body weight were monitored. Also, blood chemistry, bilirubin, and alanine aminotransferase were assayed. Furthermore, the activity of catalase, thiobarbituric acid reactive species, mitochondrial superoxide dismutase, glutathione and glutathione peroxidase were determined in isolated kidney mitochondria. Our results show that <i>guishe</i> extracts have no antidiabetic properties at any dose. Nevertheless, it was able to diminish serum triglyceride levels and regulate the oxidative stress observed in isolated kidney mitochondria. These observations indicate that the aqueous extract from <i>guishe</i> can be used to treat abnormalities in serum lipids, as a hypolipidemic, and mitigate the oxidative stress, as an antioxidant, occurring during diabetes.Edgar R. Esquivel-GutiérrezSalvador Manzo-AvalosDonovan J. Peña-MontesAlfredo Saavedra-MolinaZoé P. MorreeuwAna G. ReyesMDPI AGarticlediabetesdyslipidemiasflavonoidsoxidative stresssaponinsBotanyQK1-989ENPlants, Vol 10, Iss 2492, p 2492 (2021)
institution DOAJ
collection DOAJ
language EN
topic diabetes
dyslipidemias
flavonoids
oxidative stress
saponins
Botany
QK1-989
spellingShingle diabetes
dyslipidemias
flavonoids
oxidative stress
saponins
Botany
QK1-989
Edgar R. Esquivel-Gutiérrez
Salvador Manzo-Avalos
Donovan J. Peña-Montes
Alfredo Saavedra-Molina
Zoé P. Morreeuw
Ana G. Reyes
Hypolipidemic and Antioxidant Effects of <i>Guishe</i> Extract from <i>Agave lechuguilla,</i> a Mexican Plant with Biotechnological Potential, on Streptozotocin-Induced Diabetic Male Rats
description In the present study, we used a by-product from <i>Agave lechuguilla</i> (<i>guishe</i>) to test its antidiabetic effect, hypolipidemic activity, and capacity to mitigate the oxidative stress in kidney mitochondria from streptozotocin-induced diabetic rats. Orally, a crude aqueous extract from lyophilized <i>guishe</i> was administered over 5 weeks at different doses. Blood glucose and body weight were monitored. Also, blood chemistry, bilirubin, and alanine aminotransferase were assayed. Furthermore, the activity of catalase, thiobarbituric acid reactive species, mitochondrial superoxide dismutase, glutathione and glutathione peroxidase were determined in isolated kidney mitochondria. Our results show that <i>guishe</i> extracts have no antidiabetic properties at any dose. Nevertheless, it was able to diminish serum triglyceride levels and regulate the oxidative stress observed in isolated kidney mitochondria. These observations indicate that the aqueous extract from <i>guishe</i> can be used to treat abnormalities in serum lipids, as a hypolipidemic, and mitigate the oxidative stress, as an antioxidant, occurring during diabetes.
format article
author Edgar R. Esquivel-Gutiérrez
Salvador Manzo-Avalos
Donovan J. Peña-Montes
Alfredo Saavedra-Molina
Zoé P. Morreeuw
Ana G. Reyes
author_facet Edgar R. Esquivel-Gutiérrez
Salvador Manzo-Avalos
Donovan J. Peña-Montes
Alfredo Saavedra-Molina
Zoé P. Morreeuw
Ana G. Reyes
author_sort Edgar R. Esquivel-Gutiérrez
title Hypolipidemic and Antioxidant Effects of <i>Guishe</i> Extract from <i>Agave lechuguilla,</i> a Mexican Plant with Biotechnological Potential, on Streptozotocin-Induced Diabetic Male Rats
title_short Hypolipidemic and Antioxidant Effects of <i>Guishe</i> Extract from <i>Agave lechuguilla,</i> a Mexican Plant with Biotechnological Potential, on Streptozotocin-Induced Diabetic Male Rats
title_full Hypolipidemic and Antioxidant Effects of <i>Guishe</i> Extract from <i>Agave lechuguilla,</i> a Mexican Plant with Biotechnological Potential, on Streptozotocin-Induced Diabetic Male Rats
title_fullStr Hypolipidemic and Antioxidant Effects of <i>Guishe</i> Extract from <i>Agave lechuguilla,</i> a Mexican Plant with Biotechnological Potential, on Streptozotocin-Induced Diabetic Male Rats
title_full_unstemmed Hypolipidemic and Antioxidant Effects of <i>Guishe</i> Extract from <i>Agave lechuguilla,</i> a Mexican Plant with Biotechnological Potential, on Streptozotocin-Induced Diabetic Male Rats
title_sort hypolipidemic and antioxidant effects of <i>guishe</i> extract from <i>agave lechuguilla,</i> a mexican plant with biotechnological potential, on streptozotocin-induced diabetic male rats
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/8ccfefaab1594da98d0ec49d7f5e924e
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