The non-JAZ TIFY protein TIFY8 from Arabidopsis thaliana is a transcriptional repressor.

Jasmonate (JA) signalling is mediated by the JASMONATE-ZIM DOMAIN (JAZ) repressor proteins, which are degraded upon JA perception to release downstream responses. The ZIM protein domain is characteristic of the larger TIFY protein family. It is currently unknown if the atypical member TIFY8 is invol...

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Autores principales:	Amparo Cuéllar Pérez, Astrid Nagels Durand, Robin Vanden Bossche, Rebecca De Clercq, Geert Persiau, Saskia C M Van Wees, Corné M J Pieterse, Kris Gevaert, Geert De Jaeger, Alain Goossens, Laurens Pauwels
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8cd5cc5b710c4f93b266a29f0d6e4c7a
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spelling	oai:doaj.org-article:8cd5cc5b710c4f93b266a29f0d6e4c7a2021-11-18T08:38:28ZThe non-JAZ TIFY protein TIFY8 from Arabidopsis thaliana is a transcriptional repressor.1932-620310.1371/journal.pone.0084891https://doaj.org/article/8cd5cc5b710c4f93b266a29f0d6e4c7a2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24416306/?tool=EBIhttps://doaj.org/toc/1932-6203Jasmonate (JA) signalling is mediated by the JASMONATE-ZIM DOMAIN (JAZ) repressor proteins, which are degraded upon JA perception to release downstream responses. The ZIM protein domain is characteristic of the larger TIFY protein family. It is currently unknown if the atypical member TIFY8 is involved in JA signalling. Here we show that the TIFY8 ZIM domain is functional and mediated interaction with PEAPOD proteins and NINJA. TIFY8 interacted with TOPLESS through NINJA and accordingly acted as a transcriptional repressor. TIFY8 expression was inversely correlated with JAZ expression during development and after infection with Pseudomonas syringae. Nevertheless, transgenic lines with altered TIFY8 expression did not show changes in JA sensitivity. Despite the functional ZIM domain, no interaction with JAZ proteins could be found. In contrast, TIFY8 was found in protein complexes involved in regulation of dephosphorylation, deubiquitination and O-linked N-acetylglucosamine modification suggesting an important role in nuclear signal transduction.Amparo Cuéllar PérezAstrid Nagels DurandRobin Vanden BosscheRebecca De ClercqGeert PersiauSaskia C M Van WeesCorné M J PieterseKris GevaertGeert De JaegerAlain GoossensLaurens PauwelsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e84891 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amparo Cuéllar Pérez Astrid Nagels Durand Robin Vanden Bossche Rebecca De Clercq Geert Persiau Saskia C M Van Wees Corné M J Pieterse Kris Gevaert Geert De Jaeger Alain Goossens Laurens Pauwels The non-JAZ TIFY protein TIFY8 from Arabidopsis thaliana is a transcriptional repressor.
description	Jasmonate (JA) signalling is mediated by the JASMONATE-ZIM DOMAIN (JAZ) repressor proteins, which are degraded upon JA perception to release downstream responses. The ZIM protein domain is characteristic of the larger TIFY protein family. It is currently unknown if the atypical member TIFY8 is involved in JA signalling. Here we show that the TIFY8 ZIM domain is functional and mediated interaction with PEAPOD proteins and NINJA. TIFY8 interacted with TOPLESS through NINJA and accordingly acted as a transcriptional repressor. TIFY8 expression was inversely correlated with JAZ expression during development and after infection with Pseudomonas syringae. Nevertheless, transgenic lines with altered TIFY8 expression did not show changes in JA sensitivity. Despite the functional ZIM domain, no interaction with JAZ proteins could be found. In contrast, TIFY8 was found in protein complexes involved in regulation of dephosphorylation, deubiquitination and O-linked N-acetylglucosamine modification suggesting an important role in nuclear signal transduction.
format	article
author	Amparo Cuéllar Pérez Astrid Nagels Durand Robin Vanden Bossche Rebecca De Clercq Geert Persiau Saskia C M Van Wees Corné M J Pieterse Kris Gevaert Geert De Jaeger Alain Goossens Laurens Pauwels
author_facet	Amparo Cuéllar Pérez Astrid Nagels Durand Robin Vanden Bossche Rebecca De Clercq Geert Persiau Saskia C M Van Wees Corné M J Pieterse Kris Gevaert Geert De Jaeger Alain Goossens Laurens Pauwels
author_sort	Amparo Cuéllar Pérez
title	The non-JAZ TIFY protein TIFY8 from Arabidopsis thaliana is a transcriptional repressor.
title_short	The non-JAZ TIFY protein TIFY8 from Arabidopsis thaliana is a transcriptional repressor.
title_full	The non-JAZ TIFY protein TIFY8 from Arabidopsis thaliana is a transcriptional repressor.
title_fullStr	The non-JAZ TIFY protein TIFY8 from Arabidopsis thaliana is a transcriptional repressor.
title_full_unstemmed	The non-JAZ TIFY protein TIFY8 from Arabidopsis thaliana is a transcriptional repressor.
title_sort	non-jaz tify protein tify8 from arabidopsis thaliana is a transcriptional repressor.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/8cd5cc5b710c4f93b266a29f0d6e4c7a
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The non-JAZ TIFY protein TIFY8 from Arabidopsis thaliana is a transcriptional repressor.

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