Respiratory viral infections in pragmatically selected adults in intensive care units

Abstract Respiratory viruses can be detected in 18.3 to 48.9% of critically ill adults with severe respiratory tract infections (RTIs). The present study aims to assess the clinical significance of respiratory viruses in pragmatically selected adults in medical intensive care unit patients and to id...

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Autores principales:	Cong-Tat Cia, I-Ting Lin, Jen-Chieh Lee, Huey-Pin Tsai, Jen-Ren Wang, Wen-Chien Ko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8cd5e09c9f114639b76c5edf311c278c
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spelling	oai:doaj.org-article:8cd5e09c9f114639b76c5edf311c278c2021-12-02T18:09:03ZRespiratory viral infections in pragmatically selected adults in intensive care units10.1038/s41598-021-99608-y2045-2322https://doaj.org/article/8cd5e09c9f114639b76c5edf311c278c2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99608-yhttps://doaj.org/toc/2045-2322Abstract Respiratory viruses can be detected in 18.3 to 48.9% of critically ill adults with severe respiratory tract infections (RTIs). The present study aims to assess the clinical significance of respiratory viruses in pragmatically selected adults in medical intensive care unit patients and to identify factors associated with viral respiratory viral tract infections (VRTIs). We conducted a prospective study on critically ill adults with suspected RTIs without recognized respiratory pathogens. Viral cultures with monoclonal antibody identification, in-house real-time polymerase chain reaction (PCR) for influenza virus, and FilmArray respiratory panel were used to detect viral pathogens. Multivariable logistic regression was applied to identify factors associated with VRTIs. Sixty-four (40.5%) of the included 158 critically ill adults had respiratory viruses detected in their respiratory specimens. The commonly detected viruses included influenza virus (20), followed by human rhinovirus/enterovirus (11), respiratory syncitial virus (9), human metapneumovirus (9), human parainfluenza viruses (8), human adenovirus (7), and human coronaviruses (2). The FilmArray respiratory panel detected respiratory viruses in 54 (34.6%) patients, but showed negative results for seven of 13 patients with influenza A/H3 infection. In the multivariable logistic regression model, patient characters associated with VRTIs included those aged < 65 years, household contact with individuals with upper RTI, the presence of fever, cough with sputum production, and sore throat. Respiratory viruses were not uncommonly detected in the pragmatically selected adults with critical illness. The application of multiplex PCR testing for respiratory viruses in selected patient population is a practical strategy, and the viral detection rate could be further improved by the patient characters recognized in this study.Cong-Tat CiaI-Ting LinJen-Chieh LeeHuey-Pin TsaiJen-Ren WangWen-Chien KoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cong-Tat Cia I-Ting Lin Jen-Chieh Lee Huey-Pin Tsai Jen-Ren Wang Wen-Chien Ko Respiratory viral infections in pragmatically selected adults in intensive care units
description	Abstract Respiratory viruses can be detected in 18.3 to 48.9% of critically ill adults with severe respiratory tract infections (RTIs). The present study aims to assess the clinical significance of respiratory viruses in pragmatically selected adults in medical intensive care unit patients and to identify factors associated with viral respiratory viral tract infections (VRTIs). We conducted a prospective study on critically ill adults with suspected RTIs without recognized respiratory pathogens. Viral cultures with monoclonal antibody identification, in-house real-time polymerase chain reaction (PCR) for influenza virus, and FilmArray respiratory panel were used to detect viral pathogens. Multivariable logistic regression was applied to identify factors associated with VRTIs. Sixty-four (40.5%) of the included 158 critically ill adults had respiratory viruses detected in their respiratory specimens. The commonly detected viruses included influenza virus (20), followed by human rhinovirus/enterovirus (11), respiratory syncitial virus (9), human metapneumovirus (9), human parainfluenza viruses (8), human adenovirus (7), and human coronaviruses (2). The FilmArray respiratory panel detected respiratory viruses in 54 (34.6%) patients, but showed negative results for seven of 13 patients with influenza A/H3 infection. In the multivariable logistic regression model, patient characters associated with VRTIs included those aged < 65 years, household contact with individuals with upper RTI, the presence of fever, cough with sputum production, and sore throat. Respiratory viruses were not uncommonly detected in the pragmatically selected adults with critical illness. The application of multiplex PCR testing for respiratory viruses in selected patient population is a practical strategy, and the viral detection rate could be further improved by the patient characters recognized in this study.
format	article
author	Cong-Tat Cia I-Ting Lin Jen-Chieh Lee Huey-Pin Tsai Jen-Ren Wang Wen-Chien Ko
author_facet	Cong-Tat Cia I-Ting Lin Jen-Chieh Lee Huey-Pin Tsai Jen-Ren Wang Wen-Chien Ko
author_sort	Cong-Tat Cia
title	Respiratory viral infections in pragmatically selected adults in intensive care units
title_short	Respiratory viral infections in pragmatically selected adults in intensive care units
title_full	Respiratory viral infections in pragmatically selected adults in intensive care units
title_fullStr	Respiratory viral infections in pragmatically selected adults in intensive care units
title_full_unstemmed	Respiratory viral infections in pragmatically selected adults in intensive care units
title_sort	respiratory viral infections in pragmatically selected adults in intensive care units
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8cd5e09c9f114639b76c5edf311c278c
work_keys_str_mv	AT congtatcia respiratoryviralinfectionsinpragmaticallyselectedadultsinintensivecareunits AT itinglin respiratoryviralinfectionsinpragmaticallyselectedadultsinintensivecareunits AT jenchiehlee respiratoryviralinfectionsinpragmaticallyselectedadultsinintensivecareunits AT hueypintsai respiratoryviralinfectionsinpragmaticallyselectedadultsinintensivecareunits AT jenrenwang respiratoryviralinfectionsinpragmaticallyselectedadultsinintensivecareunits AT wenchienko respiratoryviralinfectionsinpragmaticallyselectedadultsinintensivecareunits
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Respiratory viral infections in pragmatically selected adults in intensive care units

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