Mendelian randomization study on atrial fibrillation and cardiovascular disease subtypes

Abstract Atrial fibrillation (AF) has been associated with numerous diseases. However, whether AF is a cause or consequence of these diseases is uncertain. To clarify, we assessed the causal role of AF on ischemic heart disease (IHD), stroke, other cardiovascular disease (CVD) subtypes, type 2 diabe...

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Autores principales:	Man Ki Kwok, Catherine Mary Schooling
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8cd6975e3fc146afbcd0840c4ecdd7ab
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spelling	oai:doaj.org-article:8cd6975e3fc146afbcd0840c4ecdd7ab2021-12-02T18:48:24ZMendelian randomization study on atrial fibrillation and cardiovascular disease subtypes10.1038/s41598-021-98058-w2045-2322https://doaj.org/article/8cd6975e3fc146afbcd0840c4ecdd7ab2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98058-whttps://doaj.org/toc/2045-2322Abstract Atrial fibrillation (AF) has been associated with numerous diseases. However, whether AF is a cause or consequence of these diseases is uncertain. To clarify, we assessed the causal role of AF on ischemic heart disease (IHD), stroke, other cardiovascular disease (CVD) subtypes, type 2 diabetes mellitus (T2DM), and late-onset AD using bi-directional two-sample Mendelian randomization (MR) among people primarily of European descent. Genetically predicted log odds of AF was associated with any stroke (odds ratio (OR) 1.22, 95% CI 1.18 to 1.27), particularly cardioembolic stroke and possibly subdural hemorrhage, with sensitivity analyses showing similar positive findings. Genetically predicted AF was also associated with arterial thromboembolism (1.32, 1.13 to 1.53), and heart failure (1.26, 1.21 to 1.30). No association of genetically predicted AF with IHD, T2DM, cognitive function, or late-onset AD was found. Conversely, genetically predicted IHD, heart failure and possibly ischemic stroke, particularly cardioembolic stroke, were positively associated with AF. Atrial fibrillation plays a role in any stroke, arterial thromboembolism, and heart failure, corroborating current clinical guidelines on the importance of preventing these complications by effective AF management. In addition, patients with IHD, heart failure or possibly ischemic stroke might be predisposed to developing AF, with implications for management.Man Ki KwokCatherine Mary SchoolingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Man Ki Kwok Catherine Mary Schooling Mendelian randomization study on atrial fibrillation and cardiovascular disease subtypes
description	Abstract Atrial fibrillation (AF) has been associated with numerous diseases. However, whether AF is a cause or consequence of these diseases is uncertain. To clarify, we assessed the causal role of AF on ischemic heart disease (IHD), stroke, other cardiovascular disease (CVD) subtypes, type 2 diabetes mellitus (T2DM), and late-onset AD using bi-directional two-sample Mendelian randomization (MR) among people primarily of European descent. Genetically predicted log odds of AF was associated with any stroke (odds ratio (OR) 1.22, 95% CI 1.18 to 1.27), particularly cardioembolic stroke and possibly subdural hemorrhage, with sensitivity analyses showing similar positive findings. Genetically predicted AF was also associated with arterial thromboembolism (1.32, 1.13 to 1.53), and heart failure (1.26, 1.21 to 1.30). No association of genetically predicted AF with IHD, T2DM, cognitive function, or late-onset AD was found. Conversely, genetically predicted IHD, heart failure and possibly ischemic stroke, particularly cardioembolic stroke, were positively associated with AF. Atrial fibrillation plays a role in any stroke, arterial thromboembolism, and heart failure, corroborating current clinical guidelines on the importance of preventing these complications by effective AF management. In addition, patients with IHD, heart failure or possibly ischemic stroke might be predisposed to developing AF, with implications for management.
format	article
author	Man Ki Kwok Catherine Mary Schooling
author_facet	Man Ki Kwok Catherine Mary Schooling
author_sort	Man Ki Kwok
title	Mendelian randomization study on atrial fibrillation and cardiovascular disease subtypes
title_short	Mendelian randomization study on atrial fibrillation and cardiovascular disease subtypes
title_full	Mendelian randomization study on atrial fibrillation and cardiovascular disease subtypes
title_fullStr	Mendelian randomization study on atrial fibrillation and cardiovascular disease subtypes
title_full_unstemmed	Mendelian randomization study on atrial fibrillation and cardiovascular disease subtypes
title_sort	mendelian randomization study on atrial fibrillation and cardiovascular disease subtypes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8cd6975e3fc146afbcd0840c4ecdd7ab
work_keys_str_mv	AT mankikwok mendelianrandomizationstudyonatrialfibrillationandcardiovasculardiseasesubtypes AT catherinemaryschooling mendelianrandomizationstudyonatrialfibrillationandcardiovasculardiseasesubtypes
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Mendelian randomization study on atrial fibrillation and cardiovascular disease subtypes

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