Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

Enzalutamide, an approved drug for prostate cancer, acts on TMPRSS2 expression, a key mediator for SARS-CoV-2 infection. Here, the authors characterize the anti-SARS-CoV-2 effects of Enzalutamide in prostate cancer cells, lung cancer cells, human lung organoids and in hACE2-transduced Tmprss2 knocko...

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Autores principales: Fei Li, Ming Han, Pengfei Dai, Wei Xu, Juan He, Xiaoting Tao, Yang Wu, Xinyuan Tong, Xinyi Xia, Wangxin Guo, Yunjiao Zhou, Yunguang Li, Yiqin Zhu, Xiaoyu Zhang, Zhuang Liu, Rebiguli Aji, Xia Cai, Yutang Li, Di Qu, Yu Chen, Shibo Jiang, Qiao Wang, Hongbin Ji, Youhua Xie, Yihua Sun, Lu Lu, Dong Gao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/8cd722a7f3344c2295d560f85a3a6ec3
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spelling oai:doaj.org-article:8cd722a7f3344c2295d560f85a3a6ec32021-12-02T14:26:44ZDistinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide10.1038/s41467-021-21171-x2041-1723https://doaj.org/article/8cd722a7f3344c2295d560f85a3a6ec32021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21171-xhttps://doaj.org/toc/2041-1723Enzalutamide, an approved drug for prostate cancer, acts on TMPRSS2 expression, a key mediator for SARS-CoV-2 infection. Here, the authors characterize the anti-SARS-CoV-2 effects of Enzalutamide in prostate cancer cells, lung cancer cells, human lung organoids and in hACE2-transduced Tmprss2 knockout mice and show lack antiviral action in human lung cells and human lung organoids, likely due to the AR-independent TMPRSS2 expression in mouse and human lung epithelial cells.Fei LiMing HanPengfei DaiWei XuJuan HeXiaoting TaoYang WuXinyuan TongXinyi XiaWangxin GuoYunjiao ZhouYunguang LiYiqin ZhuXiaoyu ZhangZhuang LiuRebiguli AjiXia CaiYutang LiDi QuYu ChenShibo JiangQiao WangHongbin JiYouhua XieYihua SunLu LuDong GaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Fei Li
Ming Han
Pengfei Dai
Wei Xu
Juan He
Xiaoting Tao
Yang Wu
Xinyuan Tong
Xinyi Xia
Wangxin Guo
Yunjiao Zhou
Yunguang Li
Yiqin Zhu
Xiaoyu Zhang
Zhuang Liu
Rebiguli Aji
Xia Cai
Yutang Li
Di Qu
Yu Chen
Shibo Jiang
Qiao Wang
Hongbin Ji
Youhua Xie
Yihua Sun
Lu Lu
Dong Gao
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide
description Enzalutamide, an approved drug for prostate cancer, acts on TMPRSS2 expression, a key mediator for SARS-CoV-2 infection. Here, the authors characterize the anti-SARS-CoV-2 effects of Enzalutamide in prostate cancer cells, lung cancer cells, human lung organoids and in hACE2-transduced Tmprss2 knockout mice and show lack antiviral action in human lung cells and human lung organoids, likely due to the AR-independent TMPRSS2 expression in mouse and human lung epithelial cells.
format article
author Fei Li
Ming Han
Pengfei Dai
Wei Xu
Juan He
Xiaoting Tao
Yang Wu
Xinyuan Tong
Xinyi Xia
Wangxin Guo
Yunjiao Zhou
Yunguang Li
Yiqin Zhu
Xiaoyu Zhang
Zhuang Liu
Rebiguli Aji
Xia Cai
Yutang Li
Di Qu
Yu Chen
Shibo Jiang
Qiao Wang
Hongbin Ji
Youhua Xie
Yihua Sun
Lu Lu
Dong Gao
author_facet Fei Li
Ming Han
Pengfei Dai
Wei Xu
Juan He
Xiaoting Tao
Yang Wu
Xinyuan Tong
Xinyi Xia
Wangxin Guo
Yunjiao Zhou
Yunguang Li
Yiqin Zhu
Xiaoyu Zhang
Zhuang Liu
Rebiguli Aji
Xia Cai
Yutang Li
Di Qu
Yu Chen
Shibo Jiang
Qiao Wang
Hongbin Ji
Youhua Xie
Yihua Sun
Lu Lu
Dong Gao
author_sort Fei Li
title Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide
title_short Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide
title_full Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide
title_fullStr Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide
title_full_unstemmed Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide
title_sort distinct mechanisms for tmprss2 expression explain organ-specific inhibition of sars-cov-2 infection by enzalutamide
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/8cd722a7f3344c2295d560f85a3a6ec3
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