p53/FBXL20 axis negatively regulates the protein stability of PR55α, a regulatory subunit of PP2A Ser/Thr phosphatase

We have previously reported an important role of PR55α, a regulatory subunit of PP2A Ser/Thr phosphatase, in the support of critical oncogenic pathways required for oncogenesis and the malignant phenotype of pancreatic cancer. The studies in this report reveal a novel mechanism by which the p53 tumo...

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Autores principales: Lepakshe S.V. Madduri, Nichole D. Brandquist, Chitra Palanivel, Geoffrey A. Talmon, Michael J. Baine, Sumin Zhou, Charles A. Enke, Keith R. Johnson, Michel M. Ouellette, Ying Yan
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
p53
Acceso en línea:https://doaj.org/article/8cdb3c1f0b98459aa43240965cbaf58f
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