Vagal determinants of exercise capacity

Demonstrating a causal relationship between cardiac vagal tone and exercise capacity has been previously limited by methodological constraints. Using genetic targeting, silencing and optogenetic recruitment of vagal motor neuron activity in rodents, Machhadaet al. provide direct evidence that vagal...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Asif Machhada, Stefan Trapp, Nephtali Marina, Robert C.M. Stephens, John Whittle, Mark F. Lythgoe, Sergey Kasparov, Gareth L. Ackland, Alexander V. Gourine
Format: article
Langue:EN
Publié: Nature Portfolio 2017
Sujets:
Q
Accès en ligne:https://doaj.org/article/8cdfec5411aa48e89ca82cdf35f8635d
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
Description
Résumé:Demonstrating a causal relationship between cardiac vagal tone and exercise capacity has been previously limited by methodological constraints. Using genetic targeting, silencing and optogenetic recruitment of vagal motor neuron activity in rodents, Machhadaet al. provide direct evidence that vagal drive determines the ability to exercise.