Vagal determinants of exercise capacity

Demonstrating a causal relationship between cardiac vagal tone and exercise capacity has been previously limited by methodological constraints. Using genetic targeting, silencing and optogenetic recruitment of vagal motor neuron activity in rodents, Machhadaet al. provide direct evidence that vagal...

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Auteurs principaux:	Asif Machhada, Stefan Trapp, Nephtali Marina, Robert C.M. Stephens, John Whittle, Mark F. Lythgoe, Sergey Kasparov, Gareth L. Ackland, Alexander V. Gourine
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/8cdfec5411aa48e89ca82cdf35f8635d
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id	oai:doaj.org-article:8cdfec5411aa48e89ca82cdf35f8635d
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spelling	oai:doaj.org-article:8cdfec5411aa48e89ca82cdf35f8635d2021-12-02T14:42:35ZVagal determinants of exercise capacity10.1038/ncomms150972041-1723https://doaj.org/article/8cdfec5411aa48e89ca82cdf35f8635d2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15097https://doaj.org/toc/2041-1723Demonstrating a causal relationship between cardiac vagal tone and exercise capacity has been previously limited by methodological constraints. Using genetic targeting, silencing and optogenetic recruitment of vagal motor neuron activity in rodents, Machhadaet al. provide direct evidence that vagal drive determines the ability to exercise.Asif MachhadaStefan TrappNephtali MarinaRobert C.M. StephensJohn WhittleMark F. LythgoeSergey KasparovGareth L. AcklandAlexander V. GourineNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Asif Machhada Stefan Trapp Nephtali Marina Robert C.M. Stephens John Whittle Mark F. Lythgoe Sergey Kasparov Gareth L. Ackland Alexander V. Gourine Vagal determinants of exercise capacity
description	Demonstrating a causal relationship between cardiac vagal tone and exercise capacity has been previously limited by methodological constraints. Using genetic targeting, silencing and optogenetic recruitment of vagal motor neuron activity in rodents, Machhadaet al. provide direct evidence that vagal drive determines the ability to exercise.
format	article
author	Asif Machhada Stefan Trapp Nephtali Marina Robert C.M. Stephens John Whittle Mark F. Lythgoe Sergey Kasparov Gareth L. Ackland Alexander V. Gourine
author_facet	Asif Machhada Stefan Trapp Nephtali Marina Robert C.M. Stephens John Whittle Mark F. Lythgoe Sergey Kasparov Gareth L. Ackland Alexander V. Gourine
author_sort	Asif Machhada
title	Vagal determinants of exercise capacity
title_short	Vagal determinants of exercise capacity
title_full	Vagal determinants of exercise capacity
title_fullStr	Vagal determinants of exercise capacity
title_full_unstemmed	Vagal determinants of exercise capacity
title_sort	vagal determinants of exercise capacity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8cdfec5411aa48e89ca82cdf35f8635d
work_keys_str_mv	AT asifmachhada vagaldeterminantsofexercisecapacity AT stefantrapp vagaldeterminantsofexercisecapacity AT nephtalimarina vagaldeterminantsofexercisecapacity AT robertcmstephens vagaldeterminantsofexercisecapacity AT johnwhittle vagaldeterminantsofexercisecapacity AT markflythgoe vagaldeterminantsofexercisecapacity AT sergeykasparov vagaldeterminantsofexercisecapacity AT garethlackland vagaldeterminantsofexercisecapacity AT alexandervgourine vagaldeterminantsofexercisecapacity
_version_	1718389641720102912

Vagal determinants of exercise capacity

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