Association between serum sphingolipids and eudaimonic well-being in white U.S. adults

Abstract Emerging research has linked psychological well-being with many physiological markers as well as morbidity and mortality. In this analysis, the relationship between components of eudaimonic well-being and serum sphingolipids levels was investigated using data from a large national survey of...

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Autores principales:	Loni Berkowitz, Marcela P. Henríquez, Cristian Salazar, Eric Rojas, Guadalupe Echeverría, Gayle D. Love, Attilio Rigotti, Christopher L. Coe, Carol D. Ryff
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8ce0699a67c14f34a15c1e3f29a0d7f5
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spelling	oai:doaj.org-article:8ce0699a67c14f34a15c1e3f29a0d7f52021-12-02T16:06:09ZAssociation between serum sphingolipids and eudaimonic well-being in white U.S. adults10.1038/s41598-021-92576-32045-2322https://doaj.org/article/8ce0699a67c14f34a15c1e3f29a0d7f52021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92576-3https://doaj.org/toc/2045-2322Abstract Emerging research has linked psychological well-being with many physiological markers as well as morbidity and mortality. In this analysis, the relationship between components of eudaimonic well-being and serum sphingolipids levels was investigated using data from a large national survey of middle-aged American adults (Midlife in the United States). Health behaviors (i.e., diet, exercise, and sleep) were also examined as potential mediators of these relationships. Serum levels of total ceramides—the main molecular class of sphingolipids previously associated with several disease conditions—were inversely linked with environmental mastery. In addition, significant correlations were found between specific ceramide, dihydroceramide, and hexosylceramides species with environmental mastery, purpose in life, and self-acceptance. Using hierarchical regression and mediation analyses, health behaviors appeared to mediate these associations. However, the link between ceramides and environmental mastery was partially independent of health behaviors, suggesting the role of additional mediating factors. These findings point to sphingolipid metabolism as a novel pathway of health benefits associated with psychological well-being. In particular, having a sense of environmental mastery may promote restorative behaviors and benefit health via improved blood sphingolipid profiles.Loni BerkowitzMarcela P. HenríquezCristian SalazarEric RojasGuadalupe EcheverríaGayle D. LoveAttilio RigottiChristopher L. CoeCarol D. RyffNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Loni Berkowitz Marcela P. Henríquez Cristian Salazar Eric Rojas Guadalupe Echeverría Gayle D. Love Attilio Rigotti Christopher L. Coe Carol D. Ryff Association between serum sphingolipids and eudaimonic well-being in white U.S. adults
description	Abstract Emerging research has linked psychological well-being with many physiological markers as well as morbidity and mortality. In this analysis, the relationship between components of eudaimonic well-being and serum sphingolipids levels was investigated using data from a large national survey of middle-aged American adults (Midlife in the United States). Health behaviors (i.e., diet, exercise, and sleep) were also examined as potential mediators of these relationships. Serum levels of total ceramides—the main molecular class of sphingolipids previously associated with several disease conditions—were inversely linked with environmental mastery. In addition, significant correlations were found between specific ceramide, dihydroceramide, and hexosylceramides species with environmental mastery, purpose in life, and self-acceptance. Using hierarchical regression and mediation analyses, health behaviors appeared to mediate these associations. However, the link between ceramides and environmental mastery was partially independent of health behaviors, suggesting the role of additional mediating factors. These findings point to sphingolipid metabolism as a novel pathway of health benefits associated with psychological well-being. In particular, having a sense of environmental mastery may promote restorative behaviors and benefit health via improved blood sphingolipid profiles.
format	article
author	Loni Berkowitz Marcela P. Henríquez Cristian Salazar Eric Rojas Guadalupe Echeverría Gayle D. Love Attilio Rigotti Christopher L. Coe Carol D. Ryff
author_facet	Loni Berkowitz Marcela P. Henríquez Cristian Salazar Eric Rojas Guadalupe Echeverría Gayle D. Love Attilio Rigotti Christopher L. Coe Carol D. Ryff
author_sort	Loni Berkowitz
title	Association between serum sphingolipids and eudaimonic well-being in white U.S. adults
title_short	Association between serum sphingolipids and eudaimonic well-being in white U.S. adults
title_full	Association between serum sphingolipids and eudaimonic well-being in white U.S. adults
title_fullStr	Association between serum sphingolipids and eudaimonic well-being in white U.S. adults
title_full_unstemmed	Association between serum sphingolipids and eudaimonic well-being in white U.S. adults
title_sort	association between serum sphingolipids and eudaimonic well-being in white u.s. adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8ce0699a67c14f34a15c1e3f29a0d7f5
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Association between serum sphingolipids and eudaimonic well-being in white U.S. adults

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