The predictive role of preoperative serum glutamate dehydrogenase levels in microvascular invasion and hepatocellular carcinoma prognosis following liver transplantation—a single center retrospective study
Background As a critical metabolic substrate, glutamine is not only involved in the progression of many cancers but is also related to angiogenesis. Glutamate dehydrogenase (GLDH), a key enzyme in glutamine metabolism, has been reported to regulate tumor proliferation; however, its relationship with...
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2021
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oai:doaj.org-article:8ce13e8eaf074082bcddd24a61e2a3682021-11-05T15:05:28ZThe predictive role of preoperative serum glutamate dehydrogenase levels in microvascular invasion and hepatocellular carcinoma prognosis following liver transplantation—a single center retrospective study10.7717/peerj.124202167-8359https://doaj.org/article/8ce13e8eaf074082bcddd24a61e2a3682021-11-01T00:00:00Zhttps://peerj.com/articles/12420.pdfhttps://peerj.com/articles/12420/https://doaj.org/toc/2167-8359Background As a critical metabolic substrate, glutamine is not only involved in the progression of many cancers but is also related to angiogenesis. Glutamate dehydrogenase (GLDH), a key enzyme in glutamine metabolism, has been reported to regulate tumor proliferation; however, its relationship with microvascular invasion (MVI) is unclear. This study evaluated the ability of preoperative serum GLDH levels to predict MVI and the long-term survival of hepatocellular carcinoma (HCC) patients after liver transplantation (LT). Methods HCC patients that underwent LT from January 2015 to May 2020 at the First Affiliated Hospital of Sun Yat-Sen University were enrolled in our retrospective analysis. Clinicopathological variables were extracted from medical records. A receiver operating characteristic curve was created to determine the optimal cut-off value of GLDH for MVI. Results Preoperative GLDH was significantly elevated in the MVI-positive group (U = 454.00, p = 0.000). The optimal cut-off value of GLDH for MVI was 7.45 U/L, with an area under the curve of 0.747 (95% CI [0.639–0.856], p = 0.000). The sensitivity was 79.3%, while the specificity was 64.5%. GLDH > 7.45 U/L (p = 0.023) and maximum diameter >5 cm (p = 0.001) were independent risk factors for the presence of MVI. Patients with GLDH > 7.45 U/L had significantly poorer overall survival (p = 0.001) and recurrence-free survival (p = 0.001) after LT than patients with GLDH ≤ 7.45 U/L. Similarly, patients with MVI were associated with poor survival (p = 0.000). Conclusions Preoperative elevated serum GLDH levels predict MVI and poorer long-term survival for HCC after LT.Jinlong GongYaxiong LiJia YuTielong WangJinliang DuanAnbin HuXiaoshun HeXiaofeng ZhuPeerJ Inc.articleglutamate dehydrogenaseHepatocellular carcinomaMicrovascular invasionLiver transplantationMedicineRENPeerJ, Vol 9, p e12420 (2021) |
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glutamate dehydrogenase Hepatocellular carcinoma Microvascular invasion Liver transplantation Medicine R |
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glutamate dehydrogenase Hepatocellular carcinoma Microvascular invasion Liver transplantation Medicine R Jinlong Gong Yaxiong Li Jia Yu Tielong Wang Jinliang Duan Anbin Hu Xiaoshun He Xiaofeng Zhu The predictive role of preoperative serum glutamate dehydrogenase levels in microvascular invasion and hepatocellular carcinoma prognosis following liver transplantation—a single center retrospective study |
| description |
Background As a critical metabolic substrate, glutamine is not only involved in the progression of many cancers but is also related to angiogenesis. Glutamate dehydrogenase (GLDH), a key enzyme in glutamine metabolism, has been reported to regulate tumor proliferation; however, its relationship with microvascular invasion (MVI) is unclear. This study evaluated the ability of preoperative serum GLDH levels to predict MVI and the long-term survival of hepatocellular carcinoma (HCC) patients after liver transplantation (LT). Methods HCC patients that underwent LT from January 2015 to May 2020 at the First Affiliated Hospital of Sun Yat-Sen University were enrolled in our retrospective analysis. Clinicopathological variables were extracted from medical records. A receiver operating characteristic curve was created to determine the optimal cut-off value of GLDH for MVI. Results Preoperative GLDH was significantly elevated in the MVI-positive group (U = 454.00, p = 0.000). The optimal cut-off value of GLDH for MVI was 7.45 U/L, with an area under the curve of 0.747 (95% CI [0.639–0.856], p = 0.000). The sensitivity was 79.3%, while the specificity was 64.5%. GLDH > 7.45 U/L (p = 0.023) and maximum diameter >5 cm (p = 0.001) were independent risk factors for the presence of MVI. Patients with GLDH > 7.45 U/L had significantly poorer overall survival (p = 0.001) and recurrence-free survival (p = 0.001) after LT than patients with GLDH ≤ 7.45 U/L. Similarly, patients with MVI were associated with poor survival (p = 0.000). Conclusions Preoperative elevated serum GLDH levels predict MVI and poorer long-term survival for HCC after LT. |
| format |
article |
| author |
Jinlong Gong Yaxiong Li Jia Yu Tielong Wang Jinliang Duan Anbin Hu Xiaoshun He Xiaofeng Zhu |
| author_facet |
Jinlong Gong Yaxiong Li Jia Yu Tielong Wang Jinliang Duan Anbin Hu Xiaoshun He Xiaofeng Zhu |
| author_sort |
Jinlong Gong |
| title |
The predictive role of preoperative serum glutamate dehydrogenase levels in microvascular invasion and hepatocellular carcinoma prognosis following liver transplantation—a single center retrospective study |
| title_short |
The predictive role of preoperative serum glutamate dehydrogenase levels in microvascular invasion and hepatocellular carcinoma prognosis following liver transplantation—a single center retrospective study |
| title_full |
The predictive role of preoperative serum glutamate dehydrogenase levels in microvascular invasion and hepatocellular carcinoma prognosis following liver transplantation—a single center retrospective study |
| title_fullStr |
The predictive role of preoperative serum glutamate dehydrogenase levels in microvascular invasion and hepatocellular carcinoma prognosis following liver transplantation—a single center retrospective study |
| title_full_unstemmed |
The predictive role of preoperative serum glutamate dehydrogenase levels in microvascular invasion and hepatocellular carcinoma prognosis following liver transplantation—a single center retrospective study |
| title_sort |
predictive role of preoperative serum glutamate dehydrogenase levels in microvascular invasion and hepatocellular carcinoma prognosis following liver transplantation—a single center retrospective study |
| publisher |
PeerJ Inc. |
| publishDate |
2021 |
| url |
https://doaj.org/article/8ce13e8eaf074082bcddd24a61e2a368 |
| work_keys_str_mv |
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