Antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications

Jeffery A Weisman,1 James C Nicholson,2 Karthik Tappa,1 UdayaBhanu Jammalamadaka,1 Chester G Wilson,2 David K Mills1,3 1Center for Biomedical Engineering and Rehabilitation Science, 2Nanosystems Engineering, 3School of Biological Sciences, Louisiana Technical University, Ruston, LA, USAAbstract: Th...

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Autores principales:	Weisman JA, Nicholson JC, Tappa K, Jammalamadaka UB, Wilson CG, Mills DK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8ce14bf15fe34045829a1fe5d1850af0
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spelling	oai:doaj.org-article:8ce14bf15fe34045829a1fe5d1850af02021-12-02T01:49:52ZAntibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications1178-2013https://doaj.org/article/8ce14bf15fe34045829a1fe5d1850af02015-01-01T00:00:00Zhttp://www.dovepress.com/antibiotic-and-chemotherapeutic-enhanced-three-dimensional-printer-fil-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Jeffery A Weisman,1 James C Nicholson,2 Karthik Tappa,1 UdayaBhanu Jammalamadaka,1 Chester G Wilson,2 David K Mills1,3 1Center for Biomedical Engineering and Rehabilitation Science, 2Nanosystems Engineering, 3School of Biological Sciences, Louisiana Technical University, Ruston, LA, USAAbstract: Three-dimensional (3D) printing and additive manufacturing holds potential for highly personalized medicine, and its introduction into clinical medicine will have many implications for patient care. This paper demonstrates the first application of 3D printing as a method for the potential sustained delivery of antibiotic and chemotherapeutic drugs from constructs for patient treatment. Our design is focused on the on-demand production of anti-infective and chemotherapeutic filaments that can be used to create discs, beads, catheters, or any medical construct using a 3D printing system. The design parameters for this project were to create a system that could be modularly loaded with bioactive agents. All 3D-printed constructs were loaded with either gentamicin or methotrexate and were optimized for efficient and extended antibacterial and cancer growth-inhibiting cytostatic activity. Preliminary results demonstrate that combining gentamicin and methotrexate with polylactic acid forms a composite possessing a superior combination of strength, versatility, and enhanced drug delivery. Antibacterial effects and a reduction in proliferation of osteosarcoma cells were observed with all constructs, attesting to the technical and clinical viability of our composites. In this study, 3D constructs were loaded with gentamicin and methotrexate, but the method can be extended to many other drugs. This method could permit clinicians to provide customized and tailored treatment that allows patient-specific treatment of disease and has significant potential for use as a tunable drug delivery system with sustained-release capacity for an array of biomedical applications. Keywords: three-dimensional printing, polymers, antibacterial, drug delivery, medical deviceWeisman JANicholson JCTappa KJammalamadaka UBWilson CGMills DKDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 357-370 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Weisman JA Nicholson JC Tappa K Jammalamadaka UB Wilson CG Mills DK Antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications
description	Jeffery A Weisman,1 James C Nicholson,2 Karthik Tappa,1 UdayaBhanu Jammalamadaka,1 Chester G Wilson,2 David K Mills1,3 1Center for Biomedical Engineering and Rehabilitation Science, 2Nanosystems Engineering, 3School of Biological Sciences, Louisiana Technical University, Ruston, LA, USAAbstract: Three-dimensional (3D) printing and additive manufacturing holds potential for highly personalized medicine, and its introduction into clinical medicine will have many implications for patient care. This paper demonstrates the first application of 3D printing as a method for the potential sustained delivery of antibiotic and chemotherapeutic drugs from constructs for patient treatment. Our design is focused on the on-demand production of anti-infective and chemotherapeutic filaments that can be used to create discs, beads, catheters, or any medical construct using a 3D printing system. The design parameters for this project were to create a system that could be modularly loaded with bioactive agents. All 3D-printed constructs were loaded with either gentamicin or methotrexate and were optimized for efficient and extended antibacterial and cancer growth-inhibiting cytostatic activity. Preliminary results demonstrate that combining gentamicin and methotrexate with polylactic acid forms a composite possessing a superior combination of strength, versatility, and enhanced drug delivery. Antibacterial effects and a reduction in proliferation of osteosarcoma cells were observed with all constructs, attesting to the technical and clinical viability of our composites. In this study, 3D constructs were loaded with gentamicin and methotrexate, but the method can be extended to many other drugs. This method could permit clinicians to provide customized and tailored treatment that allows patient-specific treatment of disease and has significant potential for use as a tunable drug delivery system with sustained-release capacity for an array of biomedical applications. Keywords: three-dimensional printing, polymers, antibacterial, drug delivery, medical device
format	article
author	Weisman JA Nicholson JC Tappa K Jammalamadaka UB Wilson CG Mills DK
author_facet	Weisman JA Nicholson JC Tappa K Jammalamadaka UB Wilson CG Mills DK
author_sort	Weisman JA
title	Antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications
title_short	Antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications
title_full	Antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications
title_fullStr	Antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications
title_full_unstemmed	Antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications
title_sort	antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/8ce14bf15fe34045829a1fe5d1850af0
work_keys_str_mv	AT weismanja antibioticandchemotherapeuticenhancedthreedimensionalprinterfilamentsandconstructsforbiomedicalapplications AT nicholsonjc antibioticandchemotherapeuticenhancedthreedimensionalprinterfilamentsandconstructsforbiomedicalapplications AT tappak antibioticandchemotherapeuticenhancedthreedimensionalprinterfilamentsandconstructsforbiomedicalapplications AT jammalamadakaub antibioticandchemotherapeuticenhancedthreedimensionalprinterfilamentsandconstructsforbiomedicalapplications AT wilsoncg antibioticandchemotherapeuticenhancedthreedimensionalprinterfilamentsandconstructsforbiomedicalapplications AT millsdk antibioticandchemotherapeuticenhancedthreedimensionalprinterfilamentsandconstructsforbiomedicalapplications
_version_	1718402852800430080

Antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications

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