Transmission dynamics, clinical characteristics and sero-surveillance in the COVID-19 outbreak in a population dense area of Colombo, Sri Lanka April- May 2020.

<h4>Background</h4>The transmission dynamics of SARS-CoV-2 varies depending on social distancing measures, circulating SARS-CoV-2 variants, host factors and other environmental factors. We sought to investigate the clinical and epidemiological characteristics of a SARS-CoV-2 outbreak tha...

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Autores principales:	Chandima Jeewandara, Dinuka Guruge, Deshni Jayathilaka, Panambara Arachchige Deshan Madhusanka, Pradeep Darshana Pushpakumara, Shyrar Tanussiya Ramu, Inoka Sepali Aberathna, Danasekara Rallage Saubhagya Rasikangani Danasekara, Thilagaraj Pathmanathan, Buddhini Gunatilaka, Sauni Malavige, Yowan Dias, Ruwan Wijayamuni, Graham S Ogg, Gathsaurie Neelika Malavige
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8ce1a4137e1c42d79756d3699af55719
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spelling	oai:doaj.org-article:8ce1a4137e1c42d79756d3699af557192021-12-02T20:16:24ZTransmission dynamics, clinical characteristics and sero-surveillance in the COVID-19 outbreak in a population dense area of Colombo, Sri Lanka April- May 2020.1932-620310.1371/journal.pone.0257548https://doaj.org/article/8ce1a4137e1c42d79756d3699af557192021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257548https://doaj.org/toc/1932-6203<h4>Background</h4>The transmission dynamics of SARS-CoV-2 varies depending on social distancing measures, circulating SARS-CoV-2 variants, host factors and other environmental factors. We sought to investigate the clinical and epidemiological characteristics of a SARS-CoV-2 outbreak that occurred in a highly dense population area in Colombo, Sri Lanka from April to May 2020.<h4>Methodology/principal findings</h4>We carried out RT-qPCR for SARS-CoV2, assessed the SARS-CoV-2 specific total and neutralizing antibodies (Nabs) in a densely packed, underserved settlement (n = 2722) after identification of the index case on 15th April 2020. 89/2722 individuals were detected as infected by RT-qPCR with a secondary attack rate among close contacts being 0.077 (95% CI 0.063-0.095). Another 30 asymptomatic individuals were found to have had COVID-19 based on the presence of SARS-CoV-2 specific antibodies. However, only 61.5% of those who were initially seropositive for SARS-CoV-2 had detectable total antibodies at 120 to 160 days, while only 40.6% had detectable Nabs. 74/89 (83.1%) of RT-qPCR positive individuals were completely asymptomatic and all 15 (16.9%) who experienced symptoms were classified as having a mild illness. 18 (20.2%) were between the ages of 61 to 80. 11/89 (12.4%) had diabetes, 8/89 (9%) had cardiovascular disease and 4 (4.5%) had asthma. Of the two viruses that were sequenced and were of the B.1 and B.4 lineages with one carrying the D614G mutation.<h4>Discussion/conclusion</h4>Almost all infected individuals developed mild or asymptomatic illness despite the presence of comorbid illnesses. Since the majority of those who were in this underserved settlement were not infected despite circulation of the D614G variant, it would be important to further study environmental and host factors that lead to disease severity and transmission.Chandima JeewandaraDinuka GurugeDeshni JayathilakaPanambara Arachchige Deshan MadhusankaPradeep Darshana PushpakumaraShyrar Tanussiya RamuInoka Sepali AberathnaDanasekara Rallage Saubhagya Rasikangani DanasekaraThilagaraj PathmanathanBuddhini GunatilakaSauni MalavigeYowan DiasRuwan WijayamuniGraham S OggGathsaurie Neelika MalavigePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0257548 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chandima Jeewandara Dinuka Guruge Deshni Jayathilaka Panambara Arachchige Deshan Madhusanka Pradeep Darshana Pushpakumara Shyrar Tanussiya Ramu Inoka Sepali Aberathna Danasekara Rallage Saubhagya Rasikangani Danasekara Thilagaraj Pathmanathan Buddhini Gunatilaka Sauni Malavige Yowan Dias Ruwan Wijayamuni Graham S Ogg Gathsaurie Neelika Malavige Transmission dynamics, clinical characteristics and sero-surveillance in the COVID-19 outbreak in a population dense area of Colombo, Sri Lanka April- May 2020.
description	<h4>Background</h4>The transmission dynamics of SARS-CoV-2 varies depending on social distancing measures, circulating SARS-CoV-2 variants, host factors and other environmental factors. We sought to investigate the clinical and epidemiological characteristics of a SARS-CoV-2 outbreak that occurred in a highly dense population area in Colombo, Sri Lanka from April to May 2020.<h4>Methodology/principal findings</h4>We carried out RT-qPCR for SARS-CoV2, assessed the SARS-CoV-2 specific total and neutralizing antibodies (Nabs) in a densely packed, underserved settlement (n = 2722) after identification of the index case on 15th April 2020. 89/2722 individuals were detected as infected by RT-qPCR with a secondary attack rate among close contacts being 0.077 (95% CI 0.063-0.095). Another 30 asymptomatic individuals were found to have had COVID-19 based on the presence of SARS-CoV-2 specific antibodies. However, only 61.5% of those who were initially seropositive for SARS-CoV-2 had detectable total antibodies at 120 to 160 days, while only 40.6% had detectable Nabs. 74/89 (83.1%) of RT-qPCR positive individuals were completely asymptomatic and all 15 (16.9%) who experienced symptoms were classified as having a mild illness. 18 (20.2%) were between the ages of 61 to 80. 11/89 (12.4%) had diabetes, 8/89 (9%) had cardiovascular disease and 4 (4.5%) had asthma. Of the two viruses that were sequenced and were of the B.1 and B.4 lineages with one carrying the D614G mutation.<h4>Discussion/conclusion</h4>Almost all infected individuals developed mild or asymptomatic illness despite the presence of comorbid illnesses. Since the majority of those who were in this underserved settlement were not infected despite circulation of the D614G variant, it would be important to further study environmental and host factors that lead to disease severity and transmission.
format	article
author	Chandima Jeewandara Dinuka Guruge Deshni Jayathilaka Panambara Arachchige Deshan Madhusanka Pradeep Darshana Pushpakumara Shyrar Tanussiya Ramu Inoka Sepali Aberathna Danasekara Rallage Saubhagya Rasikangani Danasekara Thilagaraj Pathmanathan Buddhini Gunatilaka Sauni Malavige Yowan Dias Ruwan Wijayamuni Graham S Ogg Gathsaurie Neelika Malavige
author_facet	Chandima Jeewandara Dinuka Guruge Deshni Jayathilaka Panambara Arachchige Deshan Madhusanka Pradeep Darshana Pushpakumara Shyrar Tanussiya Ramu Inoka Sepali Aberathna Danasekara Rallage Saubhagya Rasikangani Danasekara Thilagaraj Pathmanathan Buddhini Gunatilaka Sauni Malavige Yowan Dias Ruwan Wijayamuni Graham S Ogg Gathsaurie Neelika Malavige
author_sort	Chandima Jeewandara
title	Transmission dynamics, clinical characteristics and sero-surveillance in the COVID-19 outbreak in a population dense area of Colombo, Sri Lanka April- May 2020.
title_short	Transmission dynamics, clinical characteristics and sero-surveillance in the COVID-19 outbreak in a population dense area of Colombo, Sri Lanka April- May 2020.
title_full	Transmission dynamics, clinical characteristics and sero-surveillance in the COVID-19 outbreak in a population dense area of Colombo, Sri Lanka April- May 2020.
title_fullStr	Transmission dynamics, clinical characteristics and sero-surveillance in the COVID-19 outbreak in a population dense area of Colombo, Sri Lanka April- May 2020.
title_full_unstemmed	Transmission dynamics, clinical characteristics and sero-surveillance in the COVID-19 outbreak in a population dense area of Colombo, Sri Lanka April- May 2020.
title_sort	transmission dynamics, clinical characteristics and sero-surveillance in the covid-19 outbreak in a population dense area of colombo, sri lanka april- may 2020.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/8ce1a4137e1c42d79756d3699af55719
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Transmission dynamics, clinical characteristics and sero-surveillance in the COVID-19 outbreak in a population dense area of Colombo, Sri Lanka April- May 2020.

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