NOTTINGHAM PROGNOSTIC INDEX IN DIFFERENT AGE GROUPS OF NEWLY DIAGNOSED BREAST CARCINOMA PATIENTS AND ITS ASSOCIATION WITH ER, PR AND HER-2-NEU RECEPTOR STATUS

Objective: To calculate Notingham Prognostic Index in all newly diagnosed patients of breast carcinoma from histopathological analysis, to compare the mean Notingham Prognostic Index between different age groups and to determine the association between Notingham Prognostic Index and ER, PR, HER2 exp...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Faryal Zafar, Tariq Sarfraz, Humaira Tariq, Saleem Ahmed Khan, Syed Raza Jaffar, Aiza Saadia
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	breast cancer estrogen receptor immunohistochemistry notingham prognostic index Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8ce23094837746f0822100cd55132511
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8ce23094837746f0822100cd55132511
record_format	dspace
spelling	oai:doaj.org-article:8ce23094837746f0822100cd551325112021-11-05T04:03:29ZNOTTINGHAM PROGNOSTIC INDEX IN DIFFERENT AGE GROUPS OF NEWLY DIAGNOSED BREAST CARCINOMA PATIENTS AND ITS ASSOCIATION WITH ER, PR AND HER-2-NEU RECEPTOR STATUS0030-96482411-8842https://doaj.org/article/8ce23094837746f0822100cd551325112019-12-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3626/2449https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To calculate Notingham Prognostic Index in all newly diagnosed patients of breast carcinoma from histopathological analysis, to compare the mean Notingham Prognostic Index between different age groups and to determine the association between Notingham Prognostic Index and ER, PR, HER2 expression. Study Design: Cross-sectional study. Place and Duration of Study: Department of Pathology, Army Medical College, Rawalpindi, Jan to Sep 2018. Methodology: A total of 138 diagnosed cases of breast cancer with age >20 years were enrolled. Notingham Prognostic Index was calculated from histopathology report and Immunohistochemistry was performed for ER, PR and HER-2-neu status. Mean Notingham Prognostic Index was measured and compared within different age groups. Association of NPI with receptor status was assessed. Results: Mean age of the study participants was 52.2 ± 12.2. Family history was positive in 40 (29%) of cases. ER expression was positive in 67 (48.6%) of patients, PR expression was positive in 44.9% 62 of patients and HER-2-neu expression was positive in 78 (56.5%) of cases. In overall study sample, mean Notingham Prognostic Index was found to be 5.53 ± 1.29 SD (95% CI; 5.32-5.75). In age group 21-30 years it was 7.56 ± 0.83 (95% CI; 6.53-8.59) and showed decreasing trend with increasing age (p=0.04). No significant difference was observed in mean Notingham Prognostic Index between receptor positive and negative cases (p>0.05). Conclusion: A statistically significant difference was found in mean Notingham Prognostic Index values across age groups.Faryal ZafarTariq SarfrazHumaira TariqSaleem Ahmed KhanSyed Raza JaffarAiza SaadiaArmy Medical College Rawalpindiarticlebreast cancerestrogen receptorimmunohistochemistrynotingham prognostic indexMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 6, Pp 1164-1168 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer estrogen receptor immunohistochemistry notingham prognostic index Medicine R Medicine (General) R5-920
spellingShingle	breast cancer estrogen receptor immunohistochemistry notingham prognostic index Medicine R Medicine (General) R5-920 Faryal Zafar Tariq Sarfraz Humaira Tariq Saleem Ahmed Khan Syed Raza Jaffar Aiza Saadia NOTTINGHAM PROGNOSTIC INDEX IN DIFFERENT AGE GROUPS OF NEWLY DIAGNOSED BREAST CARCINOMA PATIENTS AND ITS ASSOCIATION WITH ER, PR AND HER-2-NEU RECEPTOR STATUS
description	Objective: To calculate Notingham Prognostic Index in all newly diagnosed patients of breast carcinoma from histopathological analysis, to compare the mean Notingham Prognostic Index between different age groups and to determine the association between Notingham Prognostic Index and ER, PR, HER2 expression. Study Design: Cross-sectional study. Place and Duration of Study: Department of Pathology, Army Medical College, Rawalpindi, Jan to Sep 2018. Methodology: A total of 138 diagnosed cases of breast cancer with age >20 years were enrolled. Notingham Prognostic Index was calculated from histopathology report and Immunohistochemistry was performed for ER, PR and HER-2-neu status. Mean Notingham Prognostic Index was measured and compared within different age groups. Association of NPI with receptor status was assessed. Results: Mean age of the study participants was 52.2 ± 12.2. Family history was positive in 40 (29%) of cases. ER expression was positive in 67 (48.6%) of patients, PR expression was positive in 44.9% 62 of patients and HER-2-neu expression was positive in 78 (56.5%) of cases. In overall study sample, mean Notingham Prognostic Index was found to be 5.53 ± 1.29 SD (95% CI; 5.32-5.75). In age group 21-30 years it was 7.56 ± 0.83 (95% CI; 6.53-8.59) and showed decreasing trend with increasing age (p=0.04). No significant difference was observed in mean Notingham Prognostic Index between receptor positive and negative cases (p>0.05). Conclusion: A statistically significant difference was found in mean Notingham Prognostic Index values across age groups.
format	article
author	Faryal Zafar Tariq Sarfraz Humaira Tariq Saleem Ahmed Khan Syed Raza Jaffar Aiza Saadia
author_facet	Faryal Zafar Tariq Sarfraz Humaira Tariq Saleem Ahmed Khan Syed Raza Jaffar Aiza Saadia
author_sort	Faryal Zafar
title	NOTTINGHAM PROGNOSTIC INDEX IN DIFFERENT AGE GROUPS OF NEWLY DIAGNOSED BREAST CARCINOMA PATIENTS AND ITS ASSOCIATION WITH ER, PR AND HER-2-NEU RECEPTOR STATUS
title_short	NOTTINGHAM PROGNOSTIC INDEX IN DIFFERENT AGE GROUPS OF NEWLY DIAGNOSED BREAST CARCINOMA PATIENTS AND ITS ASSOCIATION WITH ER, PR AND HER-2-NEU RECEPTOR STATUS
title_full	NOTTINGHAM PROGNOSTIC INDEX IN DIFFERENT AGE GROUPS OF NEWLY DIAGNOSED BREAST CARCINOMA PATIENTS AND ITS ASSOCIATION WITH ER, PR AND HER-2-NEU RECEPTOR STATUS
title_fullStr	NOTTINGHAM PROGNOSTIC INDEX IN DIFFERENT AGE GROUPS OF NEWLY DIAGNOSED BREAST CARCINOMA PATIENTS AND ITS ASSOCIATION WITH ER, PR AND HER-2-NEU RECEPTOR STATUS
title_full_unstemmed	NOTTINGHAM PROGNOSTIC INDEX IN DIFFERENT AGE GROUPS OF NEWLY DIAGNOSED BREAST CARCINOMA PATIENTS AND ITS ASSOCIATION WITH ER, PR AND HER-2-NEU RECEPTOR STATUS
title_sort	nottingham prognostic index in different age groups of newly diagnosed breast carcinoma patients and its association with er, pr and her-2-neu receptor status
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/8ce23094837746f0822100cd55132511
work_keys_str_mv	AT faryalzafar nottinghamprognosticindexindifferentagegroupsofnewlydiagnosedbreastcarcinomapatientsanditsassociationwitherprandher2neureceptorstatus AT tariqsarfraz nottinghamprognosticindexindifferentagegroupsofnewlydiagnosedbreastcarcinomapatientsanditsassociationwitherprandher2neureceptorstatus AT humairatariq nottinghamprognosticindexindifferentagegroupsofnewlydiagnosedbreastcarcinomapatientsanditsassociationwitherprandher2neureceptorstatus AT saleemahmedkhan nottinghamprognosticindexindifferentagegroupsofnewlydiagnosedbreastcarcinomapatientsanditsassociationwitherprandher2neureceptorstatus AT syedrazajaffar nottinghamprognosticindexindifferentagegroupsofnewlydiagnosedbreastcarcinomapatientsanditsassociationwitherprandher2neureceptorstatus AT aizasaadia nottinghamprognosticindexindifferentagegroupsofnewlydiagnosedbreastcarcinomapatientsanditsassociationwitherprandher2neureceptorstatus
_version_	1718444540168241152

NOTTINGHAM PROGNOSTIC INDEX IN DIFFERENT AGE GROUPS OF NEWLY DIAGNOSED BREAST CARCINOMA PATIENTS AND ITS ASSOCIATION WITH ER, PR AND HER-2-NEU RECEPTOR STATUS

Ejemplares similares