Insights into SCP/TAPS proteins of liver flukes based on large-scale bioinformatic analyses of sequence datasets.

<h4>Background</h4>SCP/TAPS proteins of parasitic helminths have been proposed to play key roles in fundamental biological processes linked to the invasion of and establishment in their mammalian host animals, such as the transition from free-living to parasitic stages and the modulation...

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Autores principales:	Cinzia Cantacessi, Andreas Hofmann, Neil D Young, Ursula Broder, Ross S Hall, Alex Loukas, Robin B Gasser
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8ce3e4e8b82b487e9824524e8dff07a9
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spelling	oai:doaj.org-article:8ce3e4e8b82b487e9824524e8dff07a92021-11-18T07:27:08ZInsights into SCP/TAPS proteins of liver flukes based on large-scale bioinformatic analyses of sequence datasets.1932-620310.1371/journal.pone.0031164https://doaj.org/article/8ce3e4e8b82b487e9824524e8dff07a92012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22384000/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>SCP/TAPS proteins of parasitic helminths have been proposed to play key roles in fundamental biological processes linked to the invasion of and establishment in their mammalian host animals, such as the transition from free-living to parasitic stages and the modulation of host immune responses. Despite the evidence that SCP/TAPS proteins of parasitic nematodes are involved in host-parasite interactions, there is a paucity of information on this protein family for parasitic trematodes of socio-economic importance.<h4>Methodology/principal findings</h4>We conducted the first large-scale study of SCP/TAPS proteins of a range of parasitic trematodes of both human and veterinary importance (including the liver flukes Clonorchis sinensis, Opisthorchis viverrini, Fasciola hepatica and F. gigantica as well as the blood flukes Schistosoma mansoni, S. japonicum and S. haematobium). We mined all current transcriptomic and/or genomic sequence datasets from public databases, predicted secondary structures of full-length protein sequences, undertook systematic phylogenetic analyses and investigated the differential transcription of SCP/TAPS genes in O. viverrini and F. hepatica, with an emphasis on those that are up-regulated in the developmental stages infecting the mammalian host.<h4>Conclusions</h4>This work, which sheds new light on SCP/TAPS proteins, guides future structural and functional explorations of key SCP/TAPS molecules associated with diseases caused by flatworms. Future fundamental investigations of these molecules in parasites and the integration of structural and functional data could lead to new approaches for the control of parasitic diseases.Cinzia CantacessiAndreas HofmannNeil D YoungUrsula BroderRoss S HallAlex LoukasRobin B GasserPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e31164 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cinzia Cantacessi Andreas Hofmann Neil D Young Ursula Broder Ross S Hall Alex Loukas Robin B Gasser Insights into SCP/TAPS proteins of liver flukes based on large-scale bioinformatic analyses of sequence datasets.
description	<h4>Background</h4>SCP/TAPS proteins of parasitic helminths have been proposed to play key roles in fundamental biological processes linked to the invasion of and establishment in their mammalian host animals, such as the transition from free-living to parasitic stages and the modulation of host immune responses. Despite the evidence that SCP/TAPS proteins of parasitic nematodes are involved in host-parasite interactions, there is a paucity of information on this protein family for parasitic trematodes of socio-economic importance.<h4>Methodology/principal findings</h4>We conducted the first large-scale study of SCP/TAPS proteins of a range of parasitic trematodes of both human and veterinary importance (including the liver flukes Clonorchis sinensis, Opisthorchis viverrini, Fasciola hepatica and F. gigantica as well as the blood flukes Schistosoma mansoni, S. japonicum and S. haematobium). We mined all current transcriptomic and/or genomic sequence datasets from public databases, predicted secondary structures of full-length protein sequences, undertook systematic phylogenetic analyses and investigated the differential transcription of SCP/TAPS genes in O. viverrini and F. hepatica, with an emphasis on those that are up-regulated in the developmental stages infecting the mammalian host.<h4>Conclusions</h4>This work, which sheds new light on SCP/TAPS proteins, guides future structural and functional explorations of key SCP/TAPS molecules associated with diseases caused by flatworms. Future fundamental investigations of these molecules in parasites and the integration of structural and functional data could lead to new approaches for the control of parasitic diseases.
format	article
author	Cinzia Cantacessi Andreas Hofmann Neil D Young Ursula Broder Ross S Hall Alex Loukas Robin B Gasser
author_facet	Cinzia Cantacessi Andreas Hofmann Neil D Young Ursula Broder Ross S Hall Alex Loukas Robin B Gasser
author_sort	Cinzia Cantacessi
title	Insights into SCP/TAPS proteins of liver flukes based on large-scale bioinformatic analyses of sequence datasets.
title_short	Insights into SCP/TAPS proteins of liver flukes based on large-scale bioinformatic analyses of sequence datasets.
title_full	Insights into SCP/TAPS proteins of liver flukes based on large-scale bioinformatic analyses of sequence datasets.
title_fullStr	Insights into SCP/TAPS proteins of liver flukes based on large-scale bioinformatic analyses of sequence datasets.
title_full_unstemmed	Insights into SCP/TAPS proteins of liver flukes based on large-scale bioinformatic analyses of sequence datasets.
title_sort	insights into scp/taps proteins of liver flukes based on large-scale bioinformatic analyses of sequence datasets.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/8ce3e4e8b82b487e9824524e8dff07a9
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Insights into SCP/TAPS proteins of liver flukes based on large-scale bioinformatic analyses of sequence datasets.

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