Polymorphism -262C/T of catalase gene (rs1001179) in Russian and Buryat populations with essential hypertension living in the Eastern Siberia
Genetic variations that predispose individuals to complex disorders, such as essential hypertension, may be found in gene coding regions, intronic regions or in gene promoter region. Catalase is an endogenous antioxidant enzyme that neutralizes hydrogen peroxide and is induced by oxidative challenge...
Guardado en:
| Autores principales: | , |
|---|---|
| Formato: | article |
| Lenguaje: | RU |
| Publicado: |
Scientific Сentre for Family Health and Human Reproduction Problems
2015
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/8ce51803dbb340f6bd63c317d90ea025 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: | Genetic variations that predispose individuals to complex disorders, such as essential hypertension, may be found in gene coding regions, intronic regions or in gene promoter region. Catalase is an endogenous antioxidant enzyme that neutralizes hydrogen peroxide and is induced by oxidative challenge. In this report we assessed the association between polymorphism -262С/Т in the promoter region of the CAT genes (rs1001179) and essential hypertension in Russian and Buryat populations of Eastern Siberia. In Russian population the frequencies of genotypes were: CC - 58,82 %; CT - 32,35 %; TT - 8,83 %, alleles C - 75 % and T - 25 %. In Buryat population the frequencies of genotypes were: CC - 90 %; CT - 7,5 %; TT - 2,5 %, alleles C - 93,75 % and T - 6,25 %. Statistically significant differences between the frequencies in control and examined groups (х2 = 14,250; р = 0,000) were found in the group of Buryat population. |
|---|