Polymorphism -262C/T of catalase gene (rs1001179) in Russian and Buryat populations with essential hypertension living in the Eastern Siberia

Genetic variations that predispose individuals to complex disorders, such as essential hypertension, may be found in gene coding regions, intronic regions or in gene promoter region. Catalase is an endogenous antioxidant enzyme that neutralizes hydrogen peroxide and is induced by oxidative challenge...

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Autores principales:	O. A. Ershova, T. A. Bairova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2015
Materias:	oxidative stress arterial hypertension polymorphism catalase ethnos Science Q
Acceso en línea:	https://doaj.org/article/8ce51803dbb340f6bd63c317d90ea025
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spelling	oai:doaj.org-article:8ce51803dbb340f6bd63c317d90ea0252021-11-23T06:14:32ZPolymorphism -262C/T of catalase gene (rs1001179) in Russian and Buryat populations with essential hypertension living in the Eastern Siberia2541-94202587-9596https://doaj.org/article/8ce51803dbb340f6bd63c317d90ea0252015-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/74https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Genetic variations that predispose individuals to complex disorders, such as essential hypertension, may be found in gene coding regions, intronic regions or in gene promoter region. Catalase is an endogenous antioxidant enzyme that neutralizes hydrogen peroxide and is induced by oxidative challenge. In this report we assessed the association between polymorphism -262С/Т in the promoter region of the CAT genes (rs1001179) and essential hypertension in Russian and Buryat populations of Eastern Siberia. In Russian population the frequencies of genotypes were: CC - 58,82 %; CT - 32,35 %; TT - 8,83 %, alleles C - 75 % and T - 25 %. In Buryat population the frequencies of genotypes were: CC - 90 %; CT - 7,5 %; TT - 2,5 %, alleles C - 93,75 % and T - 6,25 %. Statistically significant differences between the frequencies in control and examined groups (х2 = 14,250; р = 0,000) were found in the group of Buryat population.O. A. ErshovaT. A. BairovaScientific Сentre for Family Health and Human Reproduction Problemsarticleoxidative stressarterial hypertensionpolymorphismcatalaseethnosScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3, Pp 70-73 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	oxidative stress arterial hypertension polymorphism catalase ethnos Science Q
spellingShingle	oxidative stress arterial hypertension polymorphism catalase ethnos Science Q O. A. Ershova T. A. Bairova Polymorphism -262C/T of catalase gene (rs1001179) in Russian and Buryat populations with essential hypertension living in the Eastern Siberia
description	Genetic variations that predispose individuals to complex disorders, such as essential hypertension, may be found in gene coding regions, intronic regions or in gene promoter region. Catalase is an endogenous antioxidant enzyme that neutralizes hydrogen peroxide and is induced by oxidative challenge. In this report we assessed the association between polymorphism -262С/Т in the promoter region of the CAT genes (rs1001179) and essential hypertension in Russian and Buryat populations of Eastern Siberia. In Russian population the frequencies of genotypes were: CC - 58,82 %; CT - 32,35 %; TT - 8,83 %, alleles C - 75 % and T - 25 %. In Buryat population the frequencies of genotypes were: CC - 90 %; CT - 7,5 %; TT - 2,5 %, alleles C - 93,75 % and T - 6,25 %. Statistically significant differences between the frequencies in control and examined groups (х2 = 14,250; р = 0,000) were found in the group of Buryat population.
format	article
author	O. A. Ershova T. A. Bairova
author_facet	O. A. Ershova T. A. Bairova
author_sort	O. A. Ershova
title	Polymorphism -262C/T of catalase gene (rs1001179) in Russian and Buryat populations with essential hypertension living in the Eastern Siberia
title_short	Polymorphism -262C/T of catalase gene (rs1001179) in Russian and Buryat populations with essential hypertension living in the Eastern Siberia
title_full	Polymorphism -262C/T of catalase gene (rs1001179) in Russian and Buryat populations with essential hypertension living in the Eastern Siberia
title_fullStr	Polymorphism -262C/T of catalase gene (rs1001179) in Russian and Buryat populations with essential hypertension living in the Eastern Siberia
title_full_unstemmed	Polymorphism -262C/T of catalase gene (rs1001179) in Russian and Buryat populations with essential hypertension living in the Eastern Siberia
title_sort	polymorphism -262c/t of catalase gene (rs1001179) in russian and buryat populations with essential hypertension living in the eastern siberia
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2015
url	https://doaj.org/article/8ce51803dbb340f6bd63c317d90ea025
work_keys_str_mv	AT oaershova polymorphism262ctofcatalasegeners1001179inrussianandburyatpopulationswithessentialhypertensionlivingintheeasternsiberia AT tabairova polymorphism262ctofcatalasegeners1001179inrussianandburyatpopulationswithessentialhypertensionlivingintheeasternsiberia
_version_	1718417081257426944

Polymorphism -262C/T of catalase gene (rs1001179) in Russian and Buryat populations with essential hypertension living in the Eastern Siberia

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