Microbiota in Health and Disease—Potential Clinical Applications

Within the last two decades tremendous efforts in biomedicine have been undertaken to understand the interplay of commensal bacteria living in and on our human body with our own human physiology. It became clear that (1) a high diversity especially of the microbial communities in the gut are importa...

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Autores principales:	Matthias Laudes, Corinna Geisler, Nathalie Rohmann, Jildau Bouwman, Tobias Pischon, Kristina Schlicht
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	microbiome gastroenterology oncology neurology Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/8ce6e8917db9409db4323740eebff34b
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spelling	oai:doaj.org-article:8ce6e8917db9409db4323740eebff34b2021-11-25T18:34:46ZMicrobiota in Health and Disease—Potential Clinical Applications10.3390/nu131138662072-6643https://doaj.org/article/8ce6e8917db9409db4323740eebff34b2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3866https://doaj.org/toc/2072-6643Within the last two decades tremendous efforts in biomedicine have been undertaken to understand the interplay of commensal bacteria living in and on our human body with our own human physiology. It became clear that (1) a high diversity especially of the microbial communities in the gut are important to preserve health and that (2) certain bacteria via nutrition-microbe-host metabolic axes are beneficially affecting various functions of the host, including metabolic control, energy balance and immune function. While a large set of evidence indicate a special role for small chain fatty acids (SCFA) in that context, recently also metabolites of amino acids (e.g., tryptophan and arginine) moved into scientific attention. Of interest, microbiome alterations are not only important in nutrition associated diseases like obesity and diabetes, but also in many chronic inflammatory, oncological and neurological abnormalities. From a clinician’s point of view, it should be mentioned, that the microbiome is not only interesting to develop novel therapies, but also as a modifiable factor to improve efficiency of modern pharmaceutics, e.g., immune-therapeutics in oncology. However, so far, most data rely on animal experiments or human association studies, whereas controlled clinical intervention studies are spare. Hence, the translation of the knowledge of the last decades into clinical routine will be the challenge of microbiome based biomedical research for the next years. This review aims to provide examples for future clinical applications in various entities and to suggest bacterial species and/or microbial effector molecules as potential targets for intervention studies.Matthias LaudesCorinna GeislerNathalie RohmannJildau BouwmanTobias PischonKristina SchlichtMDPI AGarticlemicrobiomegastroenterologyoncologyneurologyNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3866, p 3866 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microbiome gastroenterology oncology neurology Nutrition. Foods and food supply TX341-641
spellingShingle	microbiome gastroenterology oncology neurology Nutrition. Foods and food supply TX341-641 Matthias Laudes Corinna Geisler Nathalie Rohmann Jildau Bouwman Tobias Pischon Kristina Schlicht Microbiota in Health and Disease—Potential Clinical Applications
description	Within the last two decades tremendous efforts in biomedicine have been undertaken to understand the interplay of commensal bacteria living in and on our human body with our own human physiology. It became clear that (1) a high diversity especially of the microbial communities in the gut are important to preserve health and that (2) certain bacteria via nutrition-microbe-host metabolic axes are beneficially affecting various functions of the host, including metabolic control, energy balance and immune function. While a large set of evidence indicate a special role for small chain fatty acids (SCFA) in that context, recently also metabolites of amino acids (e.g., tryptophan and arginine) moved into scientific attention. Of interest, microbiome alterations are not only important in nutrition associated diseases like obesity and diabetes, but also in many chronic inflammatory, oncological and neurological abnormalities. From a clinician’s point of view, it should be mentioned, that the microbiome is not only interesting to develop novel therapies, but also as a modifiable factor to improve efficiency of modern pharmaceutics, e.g., immune-therapeutics in oncology. However, so far, most data rely on animal experiments or human association studies, whereas controlled clinical intervention studies are spare. Hence, the translation of the knowledge of the last decades into clinical routine will be the challenge of microbiome based biomedical research for the next years. This review aims to provide examples for future clinical applications in various entities and to suggest bacterial species and/or microbial effector molecules as potential targets for intervention studies.
format	article
author	Matthias Laudes Corinna Geisler Nathalie Rohmann Jildau Bouwman Tobias Pischon Kristina Schlicht
author_facet	Matthias Laudes Corinna Geisler Nathalie Rohmann Jildau Bouwman Tobias Pischon Kristina Schlicht
author_sort	Matthias Laudes
title	Microbiota in Health and Disease—Potential Clinical Applications
title_short	Microbiota in Health and Disease—Potential Clinical Applications
title_full	Microbiota in Health and Disease—Potential Clinical Applications
title_fullStr	Microbiota in Health and Disease—Potential Clinical Applications
title_full_unstemmed	Microbiota in Health and Disease—Potential Clinical Applications
title_sort	microbiota in health and disease—potential clinical applications
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8ce6e8917db9409db4323740eebff34b
work_keys_str_mv	AT matthiaslaudes microbiotainhealthanddiseasepotentialclinicalapplications AT corinnageisler microbiotainhealthanddiseasepotentialclinicalapplications AT nathalierohmann microbiotainhealthanddiseasepotentialclinicalapplications AT jildaubouwman microbiotainhealthanddiseasepotentialclinicalapplications AT tobiaspischon microbiotainhealthanddiseasepotentialclinicalapplications AT kristinaschlicht microbiotainhealthanddiseasepotentialclinicalapplications
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Microbiota in Health and Disease—Potential Clinical Applications

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