UBB pseudogene 4 encodes functional ubiquitin variants

Ubiquitin pseudogenes are present in many organisms but whether they encode functional proteins has remained unclear. Here, the authors show that human UBB pseudogene 4 produces ubiquitin variants with amino acid compositions and cellular functions that are distinct from canonical ubiquitin.

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Autores principales:	Marie-Line Dubois, Anna Meller, Sondos Samandi, Mylène Brunelle, Julie Frion, Marie A. Brunet, Amanda Toupin, Maxime C. Beaudoin, Jean-François Jacques, Dominique Lévesque, Michelle S. Scott, Pierre Lavigne, Xavier Roucou, François-Michel Boisvert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8ce974c41a46437d9f1dfb98b66ade74
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spelling	oai:doaj.org-article:8ce974c41a46437d9f1dfb98b66ade742021-12-02T14:41:01ZUBB pseudogene 4 encodes functional ubiquitin variants10.1038/s41467-020-15090-62041-1723https://doaj.org/article/8ce974c41a46437d9f1dfb98b66ade742020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15090-6https://doaj.org/toc/2041-1723Ubiquitin pseudogenes are present in many organisms but whether they encode functional proteins has remained unclear. Here, the authors show that human UBB pseudogene 4 produces ubiquitin variants with amino acid compositions and cellular functions that are distinct from canonical ubiquitin.Marie-Line DuboisAnna MellerSondos SamandiMylène BrunelleJulie FrionMarie A. BrunetAmanda ToupinMaxime C. BeaudoinJean-François JacquesDominique LévesqueMichelle S. ScottPierre LavigneXavier RoucouFrançois-Michel BoisvertNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marie-Line Dubois Anna Meller Sondos Samandi Mylène Brunelle Julie Frion Marie A. Brunet Amanda Toupin Maxime C. Beaudoin Jean-François Jacques Dominique Lévesque Michelle S. Scott Pierre Lavigne Xavier Roucou François-Michel Boisvert UBB pseudogene 4 encodes functional ubiquitin variants
description	Ubiquitin pseudogenes are present in many organisms but whether they encode functional proteins has remained unclear. Here, the authors show that human UBB pseudogene 4 produces ubiquitin variants with amino acid compositions and cellular functions that are distinct from canonical ubiquitin.
format	article
author	Marie-Line Dubois Anna Meller Sondos Samandi Mylène Brunelle Julie Frion Marie A. Brunet Amanda Toupin Maxime C. Beaudoin Jean-François Jacques Dominique Lévesque Michelle S. Scott Pierre Lavigne Xavier Roucou François-Michel Boisvert
author_facet	Marie-Line Dubois Anna Meller Sondos Samandi Mylène Brunelle Julie Frion Marie A. Brunet Amanda Toupin Maxime C. Beaudoin Jean-François Jacques Dominique Lévesque Michelle S. Scott Pierre Lavigne Xavier Roucou François-Michel Boisvert
author_sort	Marie-Line Dubois
title	UBB pseudogene 4 encodes functional ubiquitin variants
title_short	UBB pseudogene 4 encodes functional ubiquitin variants
title_full	UBB pseudogene 4 encodes functional ubiquitin variants
title_fullStr	UBB pseudogene 4 encodes functional ubiquitin variants
title_full_unstemmed	UBB pseudogene 4 encodes functional ubiquitin variants
title_sort	ubb pseudogene 4 encodes functional ubiquitin variants
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8ce974c41a46437d9f1dfb98b66ade74
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UBB pseudogene 4 encodes functional ubiquitin variants

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