Long timescale fMRI neuronal adaptation effects in human amblyopic cortex.

An investigation of long timescale (5 minutes) fMRI neuronal adaptation effects, based on retinotopic mapping and spatial frequency stimuli, is presented in this paper. A hierarchical linear model was developed to quantify the adaptation effects in the visual cortex. The analysis of data involved st...

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Auteurs principaux:	Xingfeng Li, Damien Coyle, Liam Maguire, Thomas M McGinnity, Robert F Hess
Format:	article
Langue:	EN
Publié:	Public Library of Science (PLoS) 2011
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/8cf52604f2744c0f85e95a5b3aa70da9
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id	oai:doaj.org-article:8cf52604f2744c0f85e95a5b3aa70da9
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spelling	oai:doaj.org-article:8cf52604f2744c0f85e95a5b3aa70da92021-11-18T07:35:23ZLong timescale fMRI neuronal adaptation effects in human amblyopic cortex.1932-620310.1371/journal.pone.0026562https://doaj.org/article/8cf52604f2744c0f85e95a5b3aa70da92011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22065999/?tool=EBIhttps://doaj.org/toc/1932-6203An investigation of long timescale (5 minutes) fMRI neuronal adaptation effects, based on retinotopic mapping and spatial frequency stimuli, is presented in this paper. A hierarchical linear model was developed to quantify the adaptation effects in the visual cortex. The analysis of data involved studying the retinotopic mapping and spatial frequency adaptation effects in the amblyopic cortex. Our results suggest that, firstly, there are many cortical regions, including V1, where neuronal adaptation effects are reduced in the cortex in response to amblyopic eye stimulation. Secondly, our results show the regional contribution is different, and it seems to start from V1 and spread to the extracortex regions. Thirdly, our results show that there is greater adaptation to broadband retinotopic mapping as opposed to narrowband spatial frequency stimulation of the amblyopic eye, and we find significant correlation between fMRI response and the magnitude of the adaptation effect, suggesting that the reduced adaptation may be a consequence of the reduced response to different stimuli reported for amblyopic eyes.Xingfeng LiDamien CoyleLiam MaguireThomas M McGinnityRobert F HessPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 10, p e26562 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xingfeng Li Damien Coyle Liam Maguire Thomas M McGinnity Robert F Hess Long timescale fMRI neuronal adaptation effects in human amblyopic cortex.
description	An investigation of long timescale (5 minutes) fMRI neuronal adaptation effects, based on retinotopic mapping and spatial frequency stimuli, is presented in this paper. A hierarchical linear model was developed to quantify the adaptation effects in the visual cortex. The analysis of data involved studying the retinotopic mapping and spatial frequency adaptation effects in the amblyopic cortex. Our results suggest that, firstly, there are many cortical regions, including V1, where neuronal adaptation effects are reduced in the cortex in response to amblyopic eye stimulation. Secondly, our results show the regional contribution is different, and it seems to start from V1 and spread to the extracortex regions. Thirdly, our results show that there is greater adaptation to broadband retinotopic mapping as opposed to narrowband spatial frequency stimulation of the amblyopic eye, and we find significant correlation between fMRI response and the magnitude of the adaptation effect, suggesting that the reduced adaptation may be a consequence of the reduced response to different stimuli reported for amblyopic eyes.
format	article
author	Xingfeng Li Damien Coyle Liam Maguire Thomas M McGinnity Robert F Hess
author_facet	Xingfeng Li Damien Coyle Liam Maguire Thomas M McGinnity Robert F Hess
author_sort	Xingfeng Li
title	Long timescale fMRI neuronal adaptation effects in human amblyopic cortex.
title_short	Long timescale fMRI neuronal adaptation effects in human amblyopic cortex.
title_full	Long timescale fMRI neuronal adaptation effects in human amblyopic cortex.
title_fullStr	Long timescale fMRI neuronal adaptation effects in human amblyopic cortex.
title_full_unstemmed	Long timescale fMRI neuronal adaptation effects in human amblyopic cortex.
title_sort	long timescale fmri neuronal adaptation effects in human amblyopic cortex.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/8cf52604f2744c0f85e95a5b3aa70da9
work_keys_str_mv	AT xingfengli longtimescalefmrineuronaladaptationeffectsinhumanamblyopiccortex AT damiencoyle longtimescalefmrineuronaladaptationeffectsinhumanamblyopiccortex AT liammaguire longtimescalefmrineuronaladaptationeffectsinhumanamblyopiccortex AT thomasmmcginnity longtimescalefmrineuronaladaptationeffectsinhumanamblyopiccortex AT robertfhess longtimescalefmrineuronaladaptationeffectsinhumanamblyopiccortex
_version_	1718423235025960960

Long timescale fMRI neuronal adaptation effects in human amblyopic cortex.

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