Modified Nanodiamonds as a Means of Polymer Surface Functionalization. From Fouling Suppression to Biosensor Design

The development of different methods for tuning surface properties is currently of great interest. The presented work is devoted to the use of modified nanodiamonds to control the wetting and biological fouling of polymers using optical sensors as an example. We have shown that, depending on the typ...

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Autores principales:	Pavel V. Melnikov, Anastasia Yu. Alexandrovskaya, Alina O. Naumova, Nadezhda M. Popova, Boris V. Spitsyn, Nikolay K. Zaitsev, Nikolay A. Yashtulov
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	detonation nanodiamond modified nanodiamond surface modification fouling protection adhesion control fluorinated material Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/8cf5df50c0b0494888d91b9d7b03ebed
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spelling	oai:doaj.org-article:8cf5df50c0b0494888d91b9d7b03ebed2021-11-25T18:31:23ZModified Nanodiamonds as a Means of Polymer Surface Functionalization. From Fouling Suppression to Biosensor Design10.3390/nano111129802079-4991https://doaj.org/article/8cf5df50c0b0494888d91b9d7b03ebed2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-4991/11/11/2980https://doaj.org/toc/2079-4991The development of different methods for tuning surface properties is currently of great interest. The presented work is devoted to the use of modified nanodiamonds to control the wetting and biological fouling of polymers using optical sensors as an example. We have shown that, depending on the type of modification and the amount of nanodiamonds, the surface of the same fluorinated polymer can have both bactericidal properties and, on the contrary, good adhesion to the biomaterial. The precise control of wetting and biofouling properties of the surface was achieved by the optimization of the modified nanodiamonds thermal anchoring conditions. In vitro and in vivo tests have shown that the fixation of amine functional groups leads to inhibition of biological activity, while the presence of a large number of polar groups of mixed composition (amide and acid chloride) promotes adhesion of the biomaterial and allows one to create a biosensor on-site. A comprehensive study made it possible to establish that in the first 5 days the observed biosensor response is provided by cells adhered to the surface due to the cell wall interaction. On the 7th day, the cells are fixed by means of the polysaccharide matrix, which provides much better retention on the surface and a noticeably greater response to substrate injections. Nevertheless, it is important to note that even 1.5 h of incubation is sufficient for the formation of the reliable bioreceptor on the surface with the modified nanodiamonds. The approach demonstrated in this work makes it possible to easily and quickly isolate the microbiome on the surface of the sensor and perform the necessary studies of its substrate specificity or resistance to toxic effects.Pavel V. MelnikovAnastasia Yu. AlexandrovskayaAlina O. NaumovaNadezhda M. PopovaBoris V. SpitsynNikolay K. ZaitsevNikolay A. YashtulovMDPI AGarticledetonation nanodiamondmodified nanodiamondsurface modificationfouling protectionadhesion controlfluorinated materialChemistryQD1-999ENNanomaterials, Vol 11, Iss 2980, p 2980 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	detonation nanodiamond modified nanodiamond surface modification fouling protection adhesion control fluorinated material Chemistry QD1-999
spellingShingle	detonation nanodiamond modified nanodiamond surface modification fouling protection adhesion control fluorinated material Chemistry QD1-999 Pavel V. Melnikov Anastasia Yu. Alexandrovskaya Alina O. Naumova Nadezhda M. Popova Boris V. Spitsyn Nikolay K. Zaitsev Nikolay A. Yashtulov Modified Nanodiamonds as a Means of Polymer Surface Functionalization. From Fouling Suppression to Biosensor Design
description	The development of different methods for tuning surface properties is currently of great interest. The presented work is devoted to the use of modified nanodiamonds to control the wetting and biological fouling of polymers using optical sensors as an example. We have shown that, depending on the type of modification and the amount of nanodiamonds, the surface of the same fluorinated polymer can have both bactericidal properties and, on the contrary, good adhesion to the biomaterial. The precise control of wetting and biofouling properties of the surface was achieved by the optimization of the modified nanodiamonds thermal anchoring conditions. In vitro and in vivo tests have shown that the fixation of amine functional groups leads to inhibition of biological activity, while the presence of a large number of polar groups of mixed composition (amide and acid chloride) promotes adhesion of the biomaterial and allows one to create a biosensor on-site. A comprehensive study made it possible to establish that in the first 5 days the observed biosensor response is provided by cells adhered to the surface due to the cell wall interaction. On the 7th day, the cells are fixed by means of the polysaccharide matrix, which provides much better retention on the surface and a noticeably greater response to substrate injections. Nevertheless, it is important to note that even 1.5 h of incubation is sufficient for the formation of the reliable bioreceptor on the surface with the modified nanodiamonds. The approach demonstrated in this work makes it possible to easily and quickly isolate the microbiome on the surface of the sensor and perform the necessary studies of its substrate specificity or resistance to toxic effects.
format	article
author	Pavel V. Melnikov Anastasia Yu. Alexandrovskaya Alina O. Naumova Nadezhda M. Popova Boris V. Spitsyn Nikolay K. Zaitsev Nikolay A. Yashtulov
author_facet	Pavel V. Melnikov Anastasia Yu. Alexandrovskaya Alina O. Naumova Nadezhda M. Popova Boris V. Spitsyn Nikolay K. Zaitsev Nikolay A. Yashtulov
author_sort	Pavel V. Melnikov
title	Modified Nanodiamonds as a Means of Polymer Surface Functionalization. From Fouling Suppression to Biosensor Design
title_short	Modified Nanodiamonds as a Means of Polymer Surface Functionalization. From Fouling Suppression to Biosensor Design
title_full	Modified Nanodiamonds as a Means of Polymer Surface Functionalization. From Fouling Suppression to Biosensor Design
title_fullStr	Modified Nanodiamonds as a Means of Polymer Surface Functionalization. From Fouling Suppression to Biosensor Design
title_full_unstemmed	Modified Nanodiamonds as a Means of Polymer Surface Functionalization. From Fouling Suppression to Biosensor Design
title_sort	modified nanodiamonds as a means of polymer surface functionalization. from fouling suppression to biosensor design
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8cf5df50c0b0494888d91b9d7b03ebed
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Modified Nanodiamonds as a Means of Polymer Surface Functionalization. From Fouling Suppression to Biosensor Design

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