Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet

Lancelet expresses an ancestral RAG transposon, ProtoRAG, which predates human RAGgenes that are responsible for V(D)J recombination and adaptive immunity repertoire generation. Here the authors show that ProtoRAG is functionally regulated by a tran s-acting factor, bbYY1, for tuning transposon acti...

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Autores principales: Song Liu, Shaochun Yuan, Xiaoman Gao, Xin Tao, Wenjuan Yu, Xu Li, Shangwu Chen, Anlong Xu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/8cf8cad9388848f799e5b8818620cbce
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Sumario:Lancelet expresses an ancestral RAG transposon, ProtoRAG, which predates human RAGgenes that are responsible for V(D)J recombination and adaptive immunity repertoire generation. Here the authors show that ProtoRAG is functionally regulated by a tran s-acting factor, bbYY1, for tuning transposon activity and maintaining genome stability.