Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet

Lancelet expresses an ancestral RAG transposon, ProtoRAG, which predates human RAGgenes that are responsible for V(D)J recombination and adaptive immunity repertoire generation. Here the authors show that ProtoRAG is functionally regulated by a tran s-acting factor, bbYY1, for tuning transposon acti...

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Auteurs principaux:	Song Liu, Shaochun Yuan, Xiaoman Gao, Xin Tao, Wenjuan Yu, Xu Li, Shangwu Chen, Anlong Xu
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/8cf8cad9388848f799e5b8818620cbce
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spelling	oai:doaj.org-article:8cf8cad9388848f799e5b8818620cbce2021-12-02T17:19:41ZFunctional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet10.1038/s41467-020-18261-72041-1723https://doaj.org/article/8cf8cad9388848f799e5b8818620cbce2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18261-7https://doaj.org/toc/2041-1723Lancelet expresses an ancestral RAG transposon, ProtoRAG, which predates human RAGgenes that are responsible for V(D)J recombination and adaptive immunity repertoire generation. Here the authors show that ProtoRAG is functionally regulated by a tran s-acting factor, bbYY1, for tuning transposon activity and maintaining genome stability.Song LiuShaochun YuanXiaoman GaoXin TaoWenjuan YuXu LiShangwu ChenAnlong XuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Song Liu Shaochun Yuan Xiaoman Gao Xin Tao Wenjuan Yu Xu Li Shangwu Chen Anlong Xu Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet
description	Lancelet expresses an ancestral RAG transposon, ProtoRAG, which predates human RAGgenes that are responsible for V(D)J recombination and adaptive immunity repertoire generation. Here the authors show that ProtoRAG is functionally regulated by a tran s-acting factor, bbYY1, for tuning transposon activity and maintaining genome stability.
format	article
author	Song Liu Shaochun Yuan Xiaoman Gao Xin Tao Wenjuan Yu Xu Li Shangwu Chen Anlong Xu
author_facet	Song Liu Shaochun Yuan Xiaoman Gao Xin Tao Wenjuan Yu Xu Li Shangwu Chen Anlong Xu
author_sort	Song Liu
title	Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet
title_short	Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet
title_full	Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet
title_fullStr	Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet
title_full_unstemmed	Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet
title_sort	functional regulation of an ancestral rag transposon protorag by a trans-acting factor yy1 in lancelet
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8cf8cad9388848f799e5b8818620cbce
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Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet

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