A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis

Formicapyridines are similar to pentacyclic fasamycin and formicamycin aromatic polyketides but with a pyridine moiety. Here the authors rationally mutate the biosynthetic gene cluster to increase production and identify a non-catalytic role for the ABM superfamily of proteins.

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Autores principales:	Zhiwei Qin, Rebecca Devine, Matthew I. Hutchings, Barrie Wilkinson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8cf9bcdb3d87424c8659c18fd8f71d39
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spelling	oai:doaj.org-article:8cf9bcdb3d87424c8659c18fd8f71d392021-12-02T17:02:09ZA role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis10.1038/s41467-019-11538-62041-1723https://doaj.org/article/8cf9bcdb3d87424c8659c18fd8f71d392019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11538-6https://doaj.org/toc/2041-1723Formicapyridines are similar to pentacyclic fasamycin and formicamycin aromatic polyketides but with a pyridine moiety. Here the authors rationally mutate the biosynthetic gene cluster to increase production and identify a non-catalytic role for the ABM superfamily of proteins.Zhiwei QinRebecca DevineMatthew I. HutchingsBarrie WilkinsonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhiwei Qin Rebecca Devine Matthew I. Hutchings Barrie Wilkinson A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis
description	Formicapyridines are similar to pentacyclic fasamycin and formicamycin aromatic polyketides but with a pyridine moiety. Here the authors rationally mutate the biosynthetic gene cluster to increase production and identify a non-catalytic role for the ABM superfamily of proteins.
format	article
author	Zhiwei Qin Rebecca Devine Matthew I. Hutchings Barrie Wilkinson
author_facet	Zhiwei Qin Rebecca Devine Matthew I. Hutchings Barrie Wilkinson
author_sort	Zhiwei Qin
title	A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis
title_short	A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis
title_full	A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis
title_fullStr	A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis
title_full_unstemmed	A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis
title_sort	role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8cf9bcdb3d87424c8659c18fd8f71d39
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A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis

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