Interleukin-22 mitigates acute respiratory distress syndrome (ARDS).

<h4>Background</h4>The goal of this study was to determine if IL-22:Fc would Acute Respiratory Distress Syndrome (ARDS).<h4>Summary background data</h4>No therapies exist for ARDS and treatment is purely supportive. Interleukin-22 (IL-22) plays an integral component in recove...

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Autores principales:	Sharven Taghavi, Olan Jackson-Weaver, Sarah Abdullah, Alanna Wanek, Robert Drury, Jacob Packer, Aaron Cotton-Betteridge, Juan Duchesne, Derek Pociask, Jay Kolls
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8cfca3eb512e481c988245ba33a718e9
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spelling	oai:doaj.org-article:8cfca3eb512e481c988245ba33a718e92021-12-02T20:13:52ZInterleukin-22 mitigates acute respiratory distress syndrome (ARDS).1932-620310.1371/journal.pone.0254985https://doaj.org/article/8cfca3eb512e481c988245ba33a718e92021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254985https://doaj.org/toc/1932-6203<h4>Background</h4>The goal of this study was to determine if IL-22:Fc would Acute Respiratory Distress Syndrome (ARDS).<h4>Summary background data</h4>No therapies exist for ARDS and treatment is purely supportive. Interleukin-22 (IL-22) plays an integral component in recovery of the lung from infection. IL-22:Fc is a recombinant protein with a human FC immunoglobulin that increases the half-life of IL-22.<h4>Study design</h4>ARDS was induced in C57BL/6 mice with intra-tracheal lipopolysaccharide (LPS) at a dose of 33.3 or 100 ug. In the low-dose LPS group (LDG), IL-22:FC was administered via tail vein injection at 30 minutes (n = 9) and compared to sham (n = 9). In the high-dose LPS group (HDG), IL-22:FC was administered (n = 11) then compared to sham (n = 8). Euthanasia occurred after bronchioalveolar lavage (BAL) on post-injury day 4.<h4>Results</h4>In the LDG, IL-22:FC resulted in decreased protein leak (0.15 vs. 0.25 ug/uL, p = 0.02). BAL protein in animals receiving IL-22:Fc in the HDG was not different. For the HDG, animals receiving IL-22:Fc had lower BAL cell counts (539,636 vs 3,147,556 cells/uL, p = 0.02). For the HDG, IL-6 (110.6 vs. 527.1 pg/mL, p = 0.04), TNF-α (5.87 vs. 25.41 pg/mL, p = 0.04), and G-CSF (95.14 vs. 659.6, p = 0.01) levels were lower in the BAL fluid of IL-22:Fc treated animals compared to sham.<h4>Conclusions</h4>IL-22:Fc decreases lung inflammation and lung capillary leak in ARDS. IL-22:Fc may be a novel therapy for ARDS.Sharven TaghaviOlan Jackson-WeaverSarah AbdullahAlanna WanekRobert DruryJacob PackerAaron Cotton-BetteridgeJuan DuchesneDerek PociaskJay KollsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0254985 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sharven Taghavi Olan Jackson-Weaver Sarah Abdullah Alanna Wanek Robert Drury Jacob Packer Aaron Cotton-Betteridge Juan Duchesne Derek Pociask Jay Kolls Interleukin-22 mitigates acute respiratory distress syndrome (ARDS).
description	<h4>Background</h4>The goal of this study was to determine if IL-22:Fc would Acute Respiratory Distress Syndrome (ARDS).<h4>Summary background data</h4>No therapies exist for ARDS and treatment is purely supportive. Interleukin-22 (IL-22) plays an integral component in recovery of the lung from infection. IL-22:Fc is a recombinant protein with a human FC immunoglobulin that increases the half-life of IL-22.<h4>Study design</h4>ARDS was induced in C57BL/6 mice with intra-tracheal lipopolysaccharide (LPS) at a dose of 33.3 or 100 ug. In the low-dose LPS group (LDG), IL-22:FC was administered via tail vein injection at 30 minutes (n = 9) and compared to sham (n = 9). In the high-dose LPS group (HDG), IL-22:FC was administered (n = 11) then compared to sham (n = 8). Euthanasia occurred after bronchioalveolar lavage (BAL) on post-injury day 4.<h4>Results</h4>In the LDG, IL-22:FC resulted in decreased protein leak (0.15 vs. 0.25 ug/uL, p = 0.02). BAL protein in animals receiving IL-22:Fc in the HDG was not different. For the HDG, animals receiving IL-22:Fc had lower BAL cell counts (539,636 vs 3,147,556 cells/uL, p = 0.02). For the HDG, IL-6 (110.6 vs. 527.1 pg/mL, p = 0.04), TNF-α (5.87 vs. 25.41 pg/mL, p = 0.04), and G-CSF (95.14 vs. 659.6, p = 0.01) levels were lower in the BAL fluid of IL-22:Fc treated animals compared to sham.<h4>Conclusions</h4>IL-22:Fc decreases lung inflammation and lung capillary leak in ARDS. IL-22:Fc may be a novel therapy for ARDS.
format	article
author	Sharven Taghavi Olan Jackson-Weaver Sarah Abdullah Alanna Wanek Robert Drury Jacob Packer Aaron Cotton-Betteridge Juan Duchesne Derek Pociask Jay Kolls
author_facet	Sharven Taghavi Olan Jackson-Weaver Sarah Abdullah Alanna Wanek Robert Drury Jacob Packer Aaron Cotton-Betteridge Juan Duchesne Derek Pociask Jay Kolls
author_sort	Sharven Taghavi
title	Interleukin-22 mitigates acute respiratory distress syndrome (ARDS).
title_short	Interleukin-22 mitigates acute respiratory distress syndrome (ARDS).
title_full	Interleukin-22 mitigates acute respiratory distress syndrome (ARDS).
title_fullStr	Interleukin-22 mitigates acute respiratory distress syndrome (ARDS).
title_full_unstemmed	Interleukin-22 mitigates acute respiratory distress syndrome (ARDS).
title_sort	interleukin-22 mitigates acute respiratory distress syndrome (ards).
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/8cfca3eb512e481c988245ba33a718e9
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Interleukin-22 mitigates acute respiratory distress syndrome (ARDS).

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