Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene

Abstract Appetitive aggression is a sub-category of instrumental aggression, characterised by the primary intrinsic enjoyment of aggressive activity. Aggression is heritable, and serotonergic and monoaminergic neurotransmitter systems have been found to contribute to the underlying molecular mechani...

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Autores principales:	Sian Megan Joanna Hemmings, Khethelo Xulu, Jessica Sommer, Martina Hinsberger, Stefanie Malan-Muller, Gerard Tromp, Thomas Elbert, Roland Weierstall, Soraya Seedat
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8cfdfd03d7354f8a8b457bb5c9aa5f08
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spelling	oai:doaj.org-article:8cfdfd03d7354f8a8b457bb5c9aa5f082021-12-02T12:31:57ZAppetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene10.1038/s41598-018-25066-82045-2322https://doaj.org/article/8cfdfd03d7354f8a8b457bb5c9aa5f082018-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25066-8https://doaj.org/toc/2045-2322Abstract Appetitive aggression is a sub-category of instrumental aggression, characterised by the primary intrinsic enjoyment of aggressive activity. Aggression is heritable, and serotonergic and monoaminergic neurotransmitter systems have been found to contribute to the underlying molecular mechanisms. The aim of this study was to investigate the role that genetic variants in the serotonin transporter (SLC6A4) and monoamine oxidase A (MAOA) genes play in the aetiology of appetitive aggression in South African Xhosa males (n = 290). SLC6A4 5-HTTLPR, rs25531, and STin2 variants, as well as MAOA-uVNTR were investigated for their association with levels of appetitive aggression using Poisson regression analysis. The STin2 VNTR12 allele was found to be associated with increased levels of appetitive aggression (p = 0.003), but with decreased levels of reactive aggression (p = 7 × 10−5). This study is the first to investigate genetic underpinnings of appetitive aggression in a South African population, with preliminary evidence suggesting that SCL6A4 STin2 variants play a role in its aetiology, and may also be important in differentiating between appetitive and reactive aggression. Although the results require replication, they shed some preliminary light on the molecular dichotomy that may underlie the two forms of aggression.Sian Megan Joanna HemmingsKhethelo XuluJessica SommerMartina HinsbergerStefanie Malan-MullerGerard TrompThomas ElbertRoland WeierstallSoraya SeedatNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sian Megan Joanna Hemmings Khethelo Xulu Jessica Sommer Martina Hinsberger Stefanie Malan-Muller Gerard Tromp Thomas Elbert Roland Weierstall Soraya Seedat Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene
description	Abstract Appetitive aggression is a sub-category of instrumental aggression, characterised by the primary intrinsic enjoyment of aggressive activity. Aggression is heritable, and serotonergic and monoaminergic neurotransmitter systems have been found to contribute to the underlying molecular mechanisms. The aim of this study was to investigate the role that genetic variants in the serotonin transporter (SLC6A4) and monoamine oxidase A (MAOA) genes play in the aetiology of appetitive aggression in South African Xhosa males (n = 290). SLC6A4 5-HTTLPR, rs25531, and STin2 variants, as well as MAOA-uVNTR were investigated for their association with levels of appetitive aggression using Poisson regression analysis. The STin2 VNTR12 allele was found to be associated with increased levels of appetitive aggression (p = 0.003), but with decreased levels of reactive aggression (p = 7 × 10−5). This study is the first to investigate genetic underpinnings of appetitive aggression in a South African population, with preliminary evidence suggesting that SCL6A4 STin2 variants play a role in its aetiology, and may also be important in differentiating between appetitive and reactive aggression. Although the results require replication, they shed some preliminary light on the molecular dichotomy that may underlie the two forms of aggression.
format	article
author	Sian Megan Joanna Hemmings Khethelo Xulu Jessica Sommer Martina Hinsberger Stefanie Malan-Muller Gerard Tromp Thomas Elbert Roland Weierstall Soraya Seedat
author_facet	Sian Megan Joanna Hemmings Khethelo Xulu Jessica Sommer Martina Hinsberger Stefanie Malan-Muller Gerard Tromp Thomas Elbert Roland Weierstall Soraya Seedat
author_sort	Sian Megan Joanna Hemmings
title	Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene
title_short	Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene
title_full	Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene
title_fullStr	Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene
title_full_unstemmed	Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene
title_sort	appetitive and reactive aggression are differentially associated with the stin2 genetic variant in the serotonin transporter gene
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8cfdfd03d7354f8a8b457bb5c9aa5f08
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Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene

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