Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans
Exposure to childhood trauma is a major risk factor for the development of almost all psychiatric disorders. By epigenome-wide studies, here, Houtepen et al. show that DNA methylation at a locus in the Kit ligand gene (KITLG) mediates the relationship between childhood trauma and cortisol stress rea...
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Nature Portfolio
2016
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oai:doaj.org-article:8d086f36e6654c299d12aa96eafaf3c52021-12-02T17:31:48ZGenome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans10.1038/ncomms109672041-1723https://doaj.org/article/8d086f36e6654c299d12aa96eafaf3c52016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10967https://doaj.org/toc/2041-1723Exposure to childhood trauma is a major risk factor for the development of almost all psychiatric disorders. By epigenome-wide studies, here, Houtepen et al. show that DNA methylation at a locus in the Kit ligand gene (KITLG) mediates the relationship between childhood trauma and cortisol stress reactivity.Lotte C. HoutepenChristiaan H. VinkersTania Carrillo-RoaMarieke HiemstraPol A. van LierWim MeeusSusan BranjeChristine M. HeimCharles B. NemeroffJonathan MillLeonard C. SchalkwykMenno P. CreyghtonRené S. KahnMarian JoëlsElisabeth B. BinderMarco P. M. BoksNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Lotte C. Houtepen Christiaan H. Vinkers Tania Carrillo-Roa Marieke Hiemstra Pol A. van Lier Wim Meeus Susan Branje Christine M. Heim Charles B. Nemeroff Jonathan Mill Leonard C. Schalkwyk Menno P. Creyghton René S. Kahn Marian Joëls Elisabeth B. Binder Marco P. M. Boks Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans |
| description |
Exposure to childhood trauma is a major risk factor for the development of almost all psychiatric disorders. By epigenome-wide studies, here, Houtepen et al. show that DNA methylation at a locus in the Kit ligand gene (KITLG) mediates the relationship between childhood trauma and cortisol stress reactivity. |
| format |
article |
| author |
Lotte C. Houtepen Christiaan H. Vinkers Tania Carrillo-Roa Marieke Hiemstra Pol A. van Lier Wim Meeus Susan Branje Christine M. Heim Charles B. Nemeroff Jonathan Mill Leonard C. Schalkwyk Menno P. Creyghton René S. Kahn Marian Joëls Elisabeth B. Binder Marco P. M. Boks |
| author_facet |
Lotte C. Houtepen Christiaan H. Vinkers Tania Carrillo-Roa Marieke Hiemstra Pol A. van Lier Wim Meeus Susan Branje Christine M. Heim Charles B. Nemeroff Jonathan Mill Leonard C. Schalkwyk Menno P. Creyghton René S. Kahn Marian Joëls Elisabeth B. Binder Marco P. M. Boks |
| author_sort |
Lotte C. Houtepen |
| title |
Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans |
| title_short |
Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans |
| title_full |
Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans |
| title_fullStr |
Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans |
| title_full_unstemmed |
Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans |
| title_sort |
genome-wide dna methylation levels and altered cortisol stress reactivity following childhood trauma in humans |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/8d086f36e6654c299d12aa96eafaf3c5 |
| work_keys_str_mv |
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1718380504127897600 |