A Zika virus from America is more efficiently transmitted than an Asian virus by Aedes aegypti mosquitoes from Asia

Abstract Zika is a mosquito-borne disease associated with neurological disorders that causes an on-going pandemic. The first outbreak was recorded in Micronesia in 2007, then in French Polynesia in 2014 from which it spread to South America in 2015 and ignited a widespread epidemic. Interestingly, Z...

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Autores principales:	Julien Pompon, Ronald Morales-Vargas, Menchie Manuel, Cheong Huat Tan, Thomas Vial, Jun Hao Tan, October M. Sessions, Pedro da Costa Vasconcelos, Lee Ching Ng, Dorothée Missé
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8d0a9f0945bf4ad5b1f087a8a59f7e27
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spelling	oai:doaj.org-article:8d0a9f0945bf4ad5b1f087a8a59f7e272021-12-02T15:05:30ZA Zika virus from America is more efficiently transmitted than an Asian virus by Aedes aegypti mosquitoes from Asia10.1038/s41598-017-01282-62045-2322https://doaj.org/article/8d0a9f0945bf4ad5b1f087a8a59f7e272017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01282-6https://doaj.org/toc/2045-2322Abstract Zika is a mosquito-borne disease associated with neurological disorders that causes an on-going pandemic. The first outbreak was recorded in Micronesia in 2007, then in French Polynesia in 2014 from which it spread to South America in 2015 and ignited a widespread epidemic. Interestingly, Zika outbreaks in Asia remained of moderate intensity although the virus is circulating. To understand these epidemiological variations, we investigated the entomological determinants of ZIKV transmission in Asia. We used oral infection of mosquitoes collected in Singapore to identify the vector species, to quantify the blood infection threshold and to compare transmissibility between an Asian ZIKV strain (H/PF13) and an American strain collected in Brazil (BE H 815744). We have confirmed the vector status of Aedes aegypti and determined that 103 pfu/ml of blood is sufficient to infect mosquitoes. We showed that only the American strain was present in the saliva 3 days post-infection, and that this strain had a 30–40% higher rate of saliva infection in Ae. aegypti from 3 to 14 days post-infection than the Asian strain. Our data suggests that American strains are more efficiently transmitted than Asian strains, which raises concerns about the introduction of American strains in Asia.Julien PomponRonald Morales-VargasMenchie ManuelCheong Huat TanThomas VialJun Hao TanOctober M. SessionsPedro da Costa VasconcelosLee Ching NgDorothée MisséNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julien Pompon Ronald Morales-Vargas Menchie Manuel Cheong Huat Tan Thomas Vial Jun Hao Tan October M. Sessions Pedro da Costa Vasconcelos Lee Ching Ng Dorothée Missé A Zika virus from America is more efficiently transmitted than an Asian virus by Aedes aegypti mosquitoes from Asia
description	Abstract Zika is a mosquito-borne disease associated with neurological disorders that causes an on-going pandemic. The first outbreak was recorded in Micronesia in 2007, then in French Polynesia in 2014 from which it spread to South America in 2015 and ignited a widespread epidemic. Interestingly, Zika outbreaks in Asia remained of moderate intensity although the virus is circulating. To understand these epidemiological variations, we investigated the entomological determinants of ZIKV transmission in Asia. We used oral infection of mosquitoes collected in Singapore to identify the vector species, to quantify the blood infection threshold and to compare transmissibility between an Asian ZIKV strain (H/PF13) and an American strain collected in Brazil (BE H 815744). We have confirmed the vector status of Aedes aegypti and determined that 103 pfu/ml of blood is sufficient to infect mosquitoes. We showed that only the American strain was present in the saliva 3 days post-infection, and that this strain had a 30–40% higher rate of saliva infection in Ae. aegypti from 3 to 14 days post-infection than the Asian strain. Our data suggests that American strains are more efficiently transmitted than Asian strains, which raises concerns about the introduction of American strains in Asia.
format	article
author	Julien Pompon Ronald Morales-Vargas Menchie Manuel Cheong Huat Tan Thomas Vial Jun Hao Tan October M. Sessions Pedro da Costa Vasconcelos Lee Ching Ng Dorothée Missé
author_facet	Julien Pompon Ronald Morales-Vargas Menchie Manuel Cheong Huat Tan Thomas Vial Jun Hao Tan October M. Sessions Pedro da Costa Vasconcelos Lee Ching Ng Dorothée Missé
author_sort	Julien Pompon
title	A Zika virus from America is more efficiently transmitted than an Asian virus by Aedes aegypti mosquitoes from Asia
title_short	A Zika virus from America is more efficiently transmitted than an Asian virus by Aedes aegypti mosquitoes from Asia
title_full	A Zika virus from America is more efficiently transmitted than an Asian virus by Aedes aegypti mosquitoes from Asia
title_fullStr	A Zika virus from America is more efficiently transmitted than an Asian virus by Aedes aegypti mosquitoes from Asia
title_full_unstemmed	A Zika virus from America is more efficiently transmitted than an Asian virus by Aedes aegypti mosquitoes from Asia
title_sort	zika virus from america is more efficiently transmitted than an asian virus by aedes aegypti mosquitoes from asia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8d0a9f0945bf4ad5b1f087a8a59f7e27
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A Zika virus from America is more efficiently transmitted than an Asian virus by Aedes aegypti mosquitoes from Asia

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