Patterns of Calcium- and Chloride-Ion Disorders and Predictors among Obese Outpatient Adults in Southern Ethiopia

Abebe Timerga,1 Kassahun Haile2 1Department of Biomedical Science, College of Medicine and Health Sciences, Wolkite University, Wolkite, Ethiopia; 2Department of Medical Laboratory Science, College of Medicine and Health Sciences, Wolkite University, Wolkite, EthiopiaCorrespondence: Abebe TimergaDep...

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Autores principales:	Timerga A, Haile K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	obesity hypochloremia hypercalcemia southern ethiopia Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/8d0d087c1d3d4363ab66578560f79a6b
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spelling	oai:doaj.org-article:8d0d087c1d3d4363ab66578560f79a6b2021-12-02T17:06:25ZPatterns of Calcium- and Chloride-Ion Disorders and Predictors among Obese Outpatient Adults in Southern Ethiopia1178-7007https://doaj.org/article/8d0d087c1d3d4363ab66578560f79a6b2021-03-01T00:00:00Zhttps://www.dovepress.com/patterns-of-calcium--and-chloride-ion-disorders-and-predictors-among-o-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Abebe Timerga,1 Kassahun Haile2 1Department of Biomedical Science, College of Medicine and Health Sciences, Wolkite University, Wolkite, Ethiopia; 2Department of Medical Laboratory Science, College of Medicine and Health Sciences, Wolkite University, Wolkite, EthiopiaCorrespondence: Abebe TimergaDepartment of Biomedical Science, College of Medicine and Health Sciences, Wolkite University, PO Box 07, Wolkite, EthiopiaTel +251 92 059-2604Fax +251 11 322 0041Email abebetimerga125@gmail.comBackground: Obesity is a condition characterized by abnormal or excess accumulation of fat in body tissue, which may impair health and result in electrolyte derangement. Hypercalcemia and hypochloremia are significant problems in obese patients, and can cause substantial morbidity and mortality. Determination of patterns of calcium and chloride may play a major role in the management of obese patients. Therefore, this study aimed to determine calcium and chloride disorders and their predictors among obese adults in the outpatient department at Wolkite University Specialized Hospital, southern Ethiopia from May to August 2020.Methods: This institution-based cross-sectional study was conducted on 250 obese adults attending the outpatient department from May to August 2020. Structured questionnaires through face-to-face interviews and participants’ medical records were used to collect information on determinants related to calcium- and chloride-ion disturbances. Levels of serum calcium and chloride were measured using an ion-selective electrode analyzer. Bivariate and multivariate logistic regression analyses were done to identify determinants associated with calcium and chloride disorders. Using ORs and 95% CIs,P< 0.05 was considered significant.Results: Among the 250 patients, 18% (95% CI 53.02– 111) and 17.6% (95% CI 0.78– 12) of study participants were hypochloremic and hypercalcemic, respectively. Age ≥ 50 years (AOR 3.58, 95% CI 2.57– 11.10), diuretic use (AOR 2.35, 95% CI 1.31– 4.23), and obesity (AOR, 6.82, 95% CI 2.26– 14.62) were independent predictors of hypochloremia on multivariate logistic regression, and obesity (AOR 9.21, 95% CI 2.50– 14.81), overweight (AOR 8.32, 95% CI 1.61– 10.20) and physical inactivity (AOR 4.28, 95% CI 1.71– 10.44) were predictors of hypercalcemia.Conclusion: High burdens of hypochloremia (18%) and hypercalcemia (17.6%) were observed in these patients. Increased age, diuretic use, being overweight, and physical inactivity were predictors of electrolyte disorders. The findings of this study should be taken into consideration to implement preventive interventions on these predictors in obese patients. Promoting sufficient fruit and vegetable consumption and physical exercise and determination of serum-chloride and -calcium levels in adult overweight/obese patients are recommended to minimize the emergence of electrolyte disorders.Keywords: obesity, hypochloremia, hypercalcemia, southern EthiopiaTimerga AHaile KDove Medical Pressarticleobesityhypochloremiahypercalcemiasouthern ethiopiaSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 1349-1358 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity hypochloremia hypercalcemia southern ethiopia Specialties of internal medicine RC581-951
spellingShingle	obesity hypochloremia hypercalcemia southern ethiopia Specialties of internal medicine RC581-951 Timerga A Haile K Patterns of Calcium- and Chloride-Ion Disorders and Predictors among Obese Outpatient Adults in Southern Ethiopia
description	Abebe Timerga,1 Kassahun Haile2 1Department of Biomedical Science, College of Medicine and Health Sciences, Wolkite University, Wolkite, Ethiopia; 2Department of Medical Laboratory Science, College of Medicine and Health Sciences, Wolkite University, Wolkite, EthiopiaCorrespondence: Abebe TimergaDepartment of Biomedical Science, College of Medicine and Health Sciences, Wolkite University, PO Box 07, Wolkite, EthiopiaTel +251 92 059-2604Fax +251 11 322 0041Email abebetimerga125@gmail.comBackground: Obesity is a condition characterized by abnormal or excess accumulation of fat in body tissue, which may impair health and result in electrolyte derangement. Hypercalcemia and hypochloremia are significant problems in obese patients, and can cause substantial morbidity and mortality. Determination of patterns of calcium and chloride may play a major role in the management of obese patients. Therefore, this study aimed to determine calcium and chloride disorders and their predictors among obese adults in the outpatient department at Wolkite University Specialized Hospital, southern Ethiopia from May to August 2020.Methods: This institution-based cross-sectional study was conducted on 250 obese adults attending the outpatient department from May to August 2020. Structured questionnaires through face-to-face interviews and participants’ medical records were used to collect information on determinants related to calcium- and chloride-ion disturbances. Levels of serum calcium and chloride were measured using an ion-selective electrode analyzer. Bivariate and multivariate logistic regression analyses were done to identify determinants associated with calcium and chloride disorders. Using ORs and 95% CIs,P< 0.05 was considered significant.Results: Among the 250 patients, 18% (95% CI 53.02– 111) and 17.6% (95% CI 0.78– 12) of study participants were hypochloremic and hypercalcemic, respectively. Age ≥ 50 years (AOR 3.58, 95% CI 2.57– 11.10), diuretic use (AOR 2.35, 95% CI 1.31– 4.23), and obesity (AOR, 6.82, 95% CI 2.26– 14.62) were independent predictors of hypochloremia on multivariate logistic regression, and obesity (AOR 9.21, 95% CI 2.50– 14.81), overweight (AOR 8.32, 95% CI 1.61– 10.20) and physical inactivity (AOR 4.28, 95% CI 1.71– 10.44) were predictors of hypercalcemia.Conclusion: High burdens of hypochloremia (18%) and hypercalcemia (17.6%) were observed in these patients. Increased age, diuretic use, being overweight, and physical inactivity were predictors of electrolyte disorders. The findings of this study should be taken into consideration to implement preventive interventions on these predictors in obese patients. Promoting sufficient fruit and vegetable consumption and physical exercise and determination of serum-chloride and -calcium levels in adult overweight/obese patients are recommended to minimize the emergence of electrolyte disorders.Keywords: obesity, hypochloremia, hypercalcemia, southern Ethiopia
format	article
author	Timerga A Haile K
author_facet	Timerga A Haile K
author_sort	Timerga A
title	Patterns of Calcium- and Chloride-Ion Disorders and Predictors among Obese Outpatient Adults in Southern Ethiopia
title_short	Patterns of Calcium- and Chloride-Ion Disorders and Predictors among Obese Outpatient Adults in Southern Ethiopia
title_full	Patterns of Calcium- and Chloride-Ion Disorders and Predictors among Obese Outpatient Adults in Southern Ethiopia
title_fullStr	Patterns of Calcium- and Chloride-Ion Disorders and Predictors among Obese Outpatient Adults in Southern Ethiopia
title_full_unstemmed	Patterns of Calcium- and Chloride-Ion Disorders and Predictors among Obese Outpatient Adults in Southern Ethiopia
title_sort	patterns of calcium- and chloride-ion disorders and predictors among obese outpatient adults in southern ethiopia
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/8d0d087c1d3d4363ab66578560f79a6b
work_keys_str_mv	AT timergaa patternsofcalciumandchlorideiondisordersandpredictorsamongobeseoutpatientadultsinsouthernethiopia AT hailek patternsofcalciumandchlorideiondisordersandpredictorsamongobeseoutpatientadultsinsouthernethiopia
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Patterns of Calcium- and Chloride-Ion Disorders and Predictors among Obese Outpatient Adults in Southern Ethiopia

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