A toxin-antidote CRISPR gene drive system for regional population modification

CRISPR homing gene drives are highly invasive and can fail due to the rapid evolution of resistance. Here the authors present TARE drive, inspired by naturally occurring selfish genetic elements, which is less vulnerable to resistance and can potentially be confined to a target population.

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Detalles Bibliográficos
Autores principales: Jackson Champer, Esther Lee, Emily Yang, Chen Liu, Andrew G. Clark, Philipp W. Messer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/8d0e866433494a27b44fe774762e8847
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Descripción
Sumario:CRISPR homing gene drives are highly invasive and can fail due to the rapid evolution of resistance. Here the authors present TARE drive, inspired by naturally occurring selfish genetic elements, which is less vulnerable to resistance and can potentially be confined to a target population.