A toxin-antidote CRISPR gene drive system for regional population modification

CRISPR homing gene drives are highly invasive and can fail due to the rapid evolution of resistance. Here the authors present TARE drive, inspired by naturally occurring selfish genetic elements, which is less vulnerable to resistance and can potentially be confined to a target population.

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Autores principales:	Jackson Champer, Esther Lee, Emily Yang, Chen Liu, Andrew G. Clark, Philipp W. Messer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8d0e866433494a27b44fe774762e8847
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spelling	oai:doaj.org-article:8d0e866433494a27b44fe774762e88472021-12-02T15:39:08ZA toxin-antidote CRISPR gene drive system for regional population modification10.1038/s41467-020-14960-32041-1723https://doaj.org/article/8d0e866433494a27b44fe774762e88472020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14960-3https://doaj.org/toc/2041-1723CRISPR homing gene drives are highly invasive and can fail due to the rapid evolution of resistance. Here the authors present TARE drive, inspired by naturally occurring selfish genetic elements, which is less vulnerable to resistance and can potentially be confined to a target population.Jackson ChamperEsther LeeEmily YangChen LiuAndrew G. ClarkPhilipp W. MesserNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jackson Champer Esther Lee Emily Yang Chen Liu Andrew G. Clark Philipp W. Messer A toxin-antidote CRISPR gene drive system for regional population modification
description	CRISPR homing gene drives are highly invasive and can fail due to the rapid evolution of resistance. Here the authors present TARE drive, inspired by naturally occurring selfish genetic elements, which is less vulnerable to resistance and can potentially be confined to a target population.
format	article
author	Jackson Champer Esther Lee Emily Yang Chen Liu Andrew G. Clark Philipp W. Messer
author_facet	Jackson Champer Esther Lee Emily Yang Chen Liu Andrew G. Clark Philipp W. Messer
author_sort	Jackson Champer
title	A toxin-antidote CRISPR gene drive system for regional population modification
title_short	A toxin-antidote CRISPR gene drive system for regional population modification
title_full	A toxin-antidote CRISPR gene drive system for regional population modification
title_fullStr	A toxin-antidote CRISPR gene drive system for regional population modification
title_full_unstemmed	A toxin-antidote CRISPR gene drive system for regional population modification
title_sort	toxin-antidote crispr gene drive system for regional population modification
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8d0e866433494a27b44fe774762e8847
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A toxin-antidote CRISPR gene drive system for regional population modification

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