Modulation of granulosa cell function via CRISPR-Cas fuelled editing of BMPR-IB gene in goats (Capra hircus)

Abstract BMPs are multifunctional growth factors implicated in regulating the ovarian function as key intra-ovarian factors. Biological effects of BMPs are mediated through binding with membrane bound receptors like BMPR-IB and initiating downstream Smad signaling pathway. FecB mutation, regarded as...

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Autores principales: Sai Kumar, Meeti Punetha, Bosco Jose, Jaya Bharati, Shivani Khanna, Arvind Sonwane, Jonathan A. Green, Kristin Whitworth, Mihir Sarkar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/8d0fd6a6a20d452fa224ad5f322251dc
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