Engineered andrographolide nanosystems for smart recovery in hepatotoxic conditions

Partha Roy,1,2 Suvadra Das,1 Runa Ghosh Auddy,1,3 Arup Mukherjee1,3 1Division of Pharmaceutical and Fine Chemicals Technology, Department of Chemical Technology, University of Calcutta, Kolkata, India; 2Faculty of Technology (Pharmaceutical), Universiti Malaysia, Pahang, Malaysia; 3Centre for Rese...

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Autores principales:	Roy P, Das S, Auddy RG, Mukherjee A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8d120a70768b4604b8c9710cb7a15768
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spelling	oai:doaj.org-article:8d120a70768b4604b8c9710cb7a157682021-12-02T01:49:53ZEngineered andrographolide nanosystems for smart recovery in hepatotoxic conditions1178-2013https://doaj.org/article/8d120a70768b4604b8c9710cb7a157682014-10-01T00:00:00Zhttp://www.dovepress.com/engineered-andrographolide-nanosystems-for-smart-recovery-in-hepatotox-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Partha Roy,1,2 Suvadra Das,1 Runa Ghosh Auddy,1,3 Arup Mukherjee1,3 1Division of Pharmaceutical and Fine Chemicals Technology, Department of Chemical Technology, University of Calcutta, Kolkata, India; 2Faculty of Technology (Pharmaceutical), Universiti Malaysia, Pahang, Malaysia; 3Centre for Research in Nanoscience and Nanotechnology, University of Calcutta, Kolkata, India Abstract: Andrographolide (AG) is one of the most potent labdane diterpenoid-type free radical scavengers available from plant sources. The compound is the principal bioactive component in Andrographis paniculata leaf extracts, and is responsible for anti-inflammatory, anticancer, and immunomodulatory activity. The application of AG in therapeutics, however, is severely constrained, due to its low aqueous solubility, short biological half-life, and poor cellular permeability. Engineered nanoparticles in biodegradable polymer systems were therefore conceived as one solution to aid in further drug-like applications of AG. In this study, a cationic modified poly(lactic-co-glycolic) acid nanosystem was applied for evaluation against experimental mouse hepatotoxic conditions. Biopolymeric nanoparticles of hydrodynamic size of 229.7±17.17 nm and ζ-potential +34.4±1.87 mV facilitated marked restoration in liver functions and oxidative stress markers. Superior dissolution for bioactive AG, hepatic residence, and favorable cytokine regulation in the liver tissues are some of the factors responsible for the newer nanosystem-assisted rapid recovery. Keywords: andrographolide, engineered nanosystems, poly(lactic-co-glycolic) acid, cytokine regulation, hepatotoxicityRoy PDas SAuddy RGMukherjee ADove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 4723-4735 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Roy P Das S Auddy RG Mukherjee A Engineered andrographolide nanosystems for smart recovery in hepatotoxic conditions
description	Partha Roy,1,2 Suvadra Das,1 Runa Ghosh Auddy,1,3 Arup Mukherjee1,3 1Division of Pharmaceutical and Fine Chemicals Technology, Department of Chemical Technology, University of Calcutta, Kolkata, India; 2Faculty of Technology (Pharmaceutical), Universiti Malaysia, Pahang, Malaysia; 3Centre for Research in Nanoscience and Nanotechnology, University of Calcutta, Kolkata, India Abstract: Andrographolide (AG) is one of the most potent labdane diterpenoid-type free radical scavengers available from plant sources. The compound is the principal bioactive component in Andrographis paniculata leaf extracts, and is responsible for anti-inflammatory, anticancer, and immunomodulatory activity. The application of AG in therapeutics, however, is severely constrained, due to its low aqueous solubility, short biological half-life, and poor cellular permeability. Engineered nanoparticles in biodegradable polymer systems were therefore conceived as one solution to aid in further drug-like applications of AG. In this study, a cationic modified poly(lactic-co-glycolic) acid nanosystem was applied for evaluation against experimental mouse hepatotoxic conditions. Biopolymeric nanoparticles of hydrodynamic size of 229.7±17.17 nm and ζ-potential +34.4±1.87 mV facilitated marked restoration in liver functions and oxidative stress markers. Superior dissolution for bioactive AG, hepatic residence, and favorable cytokine regulation in the liver tissues are some of the factors responsible for the newer nanosystem-assisted rapid recovery. Keywords: andrographolide, engineered nanosystems, poly(lactic-co-glycolic) acid, cytokine regulation, hepatotoxicity
format	article
author	Roy P Das S Auddy RG Mukherjee A
author_facet	Roy P Das S Auddy RG Mukherjee A
author_sort	Roy P
title	Engineered andrographolide nanosystems for smart recovery in hepatotoxic conditions
title_short	Engineered andrographolide nanosystems for smart recovery in hepatotoxic conditions
title_full	Engineered andrographolide nanosystems for smart recovery in hepatotoxic conditions
title_fullStr	Engineered andrographolide nanosystems for smart recovery in hepatotoxic conditions
title_full_unstemmed	Engineered andrographolide nanosystems for smart recovery in hepatotoxic conditions
title_sort	engineered andrographolide nanosystems for smart recovery in hepatotoxic conditions
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/8d120a70768b4604b8c9710cb7a15768
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Engineered andrographolide nanosystems for smart recovery in hepatotoxic conditions

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