Energy Metabolism and Intracellular pH Alteration in Neural Spheroids Carrying Down Syndrome

Energy Metabolism and Intracellular pH Alteration in Neural Spheroids Carrying Down Syndrome

Brain diseases including Down syndrome (DS/TS21) are known to be characterized by changes in cellular metabolism. To adequately assess such metabolic changes during pathological processes and to test drugs, methods are needed that allow monitoring of these changes in real time with minimally invasiv...

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Main Authors: Alena Kashirina, Alena Gavrina, Emil Kryukov, Vadim Elagin, Yuliya Kolesova, Alexander Artyuhov, Ekaterina Momotyuk, Vepa Abdyyev, Natalia Meshcheryakova, Elena Zagaynova, Erdem Dashinimaev, Aleksandra Kashina
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
iPSC
spheroids
Down syndrome
metabolism
NAD(P)H
pH
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/8d124232fe43467daa2accd9a641eaef
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https://doaj.org/article/8d124232fe43467daa2accd9a641eaef

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