Short- and long-term health consequences of sleep disruption

Goran Medic,1,2 Micheline Wille,1 Michiel EH Hemels1 1Market Access, Horizon Pharma B.V., Utrecht, 2Unit of Pharmacoepidemiology & Pharmacoeconomics, Department of Pharmacy, University of Groningen, Groningen, The Netherlands Abstract: Sleep plays a vital role in brain function and systemic...

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Autores principales:	Medic G, Wille M, Hemels ME
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	sleep sleep disorders children adolescents adults health status Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/8d13f1545c1f40939ab3dba6e0618066
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spelling	oai:doaj.org-article:8d13f1545c1f40939ab3dba6e06180662021-12-02T04:23:55ZShort- and long-term health consequences of sleep disruption1179-1608https://doaj.org/article/8d13f1545c1f40939ab3dba6e06180662017-05-01T00:00:00Zhttps://www.dovepress.com/short--and-long-term-health-consequences-of-sleep-disruption-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Goran Medic,1,2 Micheline Wille,1 Michiel EH Hemels1 1Market Access, Horizon Pharma B.V., Utrecht, 2Unit of Pharmacoepidemiology & Pharmacoeconomics, Department of Pharmacy, University of Groningen, Groningen, The Netherlands Abstract: Sleep plays a vital role in brain function and systemic physiology across many body systems. Problems with sleep are widely prevalent and include deficits in quantity and quality of sleep; sleep problems that impact the continuity of sleep are collectively referred to as sleep disruptions. Numerous factors contribute to sleep disruption, ranging from lifestyle and environmental factors to sleep disorders and other medical conditions. Sleep disruptions have substantial adverse short- and long-term health consequences. A literature search was conducted to provide a nonsystematic review of these health consequences (this review was designed to be nonsystematic to better focus on the topics of interest due to the myriad parameters affected by sleep). Sleep disruption is associated with increased activity of the sympathetic nervous system and hypothalamic–pituitary–adrenal axis, metabolic effects, changes in circadian rhythms, and proinflammatory responses. In otherwise healthy adults, short-term consequences of sleep disruption include increased stress responsivity, somatic pain, reduced quality of life, emotional distress and mood disorders, and cognitive, memory, and performance deficits. For adolescents, psychosocial health, school performance, and risk-taking behaviors are impacted by sleep disruption. Behavioral problems and cognitive functioning are associated with sleep disruption in children. Long-term consequences of sleep disruption in otherwise healthy individuals include hypertension, dyslipidemia, cardiovascular disease, weight-related issues, metabolic syndrome, type 2 diabetes mellitus, and colorectal cancer. All-cause mortality is also increased in men with sleep disturbances. For those with underlying medical conditions, sleep disruption may diminish the health-related quality of life of children and adolescents and may worsen the severity of common gastrointestinal disorders. As a result of the potential consequences of sleep disruption, health care professionals should be cognizant of how managing underlying medical conditions may help to optimize sleep continuity and consider prescribing interventions that minimize sleep disruption. Keywords: sleep, sleep disorders, children, adolescents, adults, health statusMedic GWille MHemels MEDove Medical Pressarticlesleepsleep disorderschildrenadolescentsadultshealth statusPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 9, Pp 151-161 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	sleep sleep disorders children adolescents adults health status Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	sleep sleep disorders children adolescents adults health status Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Medic G Wille M Hemels ME Short- and long-term health consequences of sleep disruption
description	Goran Medic,1,2 Micheline Wille,1 Michiel EH Hemels1 1Market Access, Horizon Pharma B.V., Utrecht, 2Unit of Pharmacoepidemiology & Pharmacoeconomics, Department of Pharmacy, University of Groningen, Groningen, The Netherlands Abstract: Sleep plays a vital role in brain function and systemic physiology across many body systems. Problems with sleep are widely prevalent and include deficits in quantity and quality of sleep; sleep problems that impact the continuity of sleep are collectively referred to as sleep disruptions. Numerous factors contribute to sleep disruption, ranging from lifestyle and environmental factors to sleep disorders and other medical conditions. Sleep disruptions have substantial adverse short- and long-term health consequences. A literature search was conducted to provide a nonsystematic review of these health consequences (this review was designed to be nonsystematic to better focus on the topics of interest due to the myriad parameters affected by sleep). Sleep disruption is associated with increased activity of the sympathetic nervous system and hypothalamic–pituitary–adrenal axis, metabolic effects, changes in circadian rhythms, and proinflammatory responses. In otherwise healthy adults, short-term consequences of sleep disruption include increased stress responsivity, somatic pain, reduced quality of life, emotional distress and mood disorders, and cognitive, memory, and performance deficits. For adolescents, psychosocial health, school performance, and risk-taking behaviors are impacted by sleep disruption. Behavioral problems and cognitive functioning are associated with sleep disruption in children. Long-term consequences of sleep disruption in otherwise healthy individuals include hypertension, dyslipidemia, cardiovascular disease, weight-related issues, metabolic syndrome, type 2 diabetes mellitus, and colorectal cancer. All-cause mortality is also increased in men with sleep disturbances. For those with underlying medical conditions, sleep disruption may diminish the health-related quality of life of children and adolescents and may worsen the severity of common gastrointestinal disorders. As a result of the potential consequences of sleep disruption, health care professionals should be cognizant of how managing underlying medical conditions may help to optimize sleep continuity and consider prescribing interventions that minimize sleep disruption. Keywords: sleep, sleep disorders, children, adolescents, adults, health status
format	article
author	Medic G Wille M Hemels ME
author_facet	Medic G Wille M Hemels ME
author_sort	Medic G
title	Short- and long-term health consequences of sleep disruption
title_short	Short- and long-term health consequences of sleep disruption
title_full	Short- and long-term health consequences of sleep disruption
title_fullStr	Short- and long-term health consequences of sleep disruption
title_full_unstemmed	Short- and long-term health consequences of sleep disruption
title_sort	short- and long-term health consequences of sleep disruption
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/8d13f1545c1f40939ab3dba6e0618066
work_keys_str_mv	AT medicg shortandlongtermhealthconsequencesofsleepdisruption AT willem shortandlongtermhealthconsequencesofsleepdisruption AT hemelsme shortandlongtermhealthconsequencesofsleepdisruption
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Short- and long-term health consequences of sleep disruption

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