NT-proBNP, C-reactive protein and soluble uPAR in a bi-ethnic male population: the SAfrEIC study.
<h4>Objective and design</h4>This cross-sectional study aimed to investigate associations between a marker of cardiac strain, the N-terminal prohormone B-type natriuretic peptide (NT-proBNP), and inflammation as reflected by either a conventional or novel inflammatory marker in a bi-ethn...
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2013
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oai:doaj.org-article:8d147cbfa05243be95459b2a683bbd7c2021-11-18T07:53:38ZNT-proBNP, C-reactive protein and soluble uPAR in a bi-ethnic male population: the SAfrEIC study.1932-620310.1371/journal.pone.0058506https://doaj.org/article/8d147cbfa05243be95459b2a683bbd7c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23516493/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective and design</h4>This cross-sectional study aimed to investigate associations between a marker of cardiac strain, the N-terminal prohormone B-type natriuretic peptide (NT-proBNP), and inflammation as reflected by either a conventional or novel inflammatory marker in a bi-ethnic South African cohort.<h4>Methods and subjects</h4>We measured NT-proBNP, C-reactive protein (CRP) and plasma-soluble urokinase plasminogen activator receptor (suPAR) levels along with conventional biomarkers in black (n = 117) and white (n = 116) men.<h4>Results</h4>NT-proBNP, CRP and suPAR levels were higher in black compared to white men. NT-proBNP was significantly associated with both CRP (r = 0.38; p = 0.001) and suPAR (r = 0.42; p<0.001) in black men only. After full adjustment in multiple regression analyses, the above associations of NT-proBNP with CRP (β = 0.199; p = 0.018) and suPAR (β = 0.257; p<0.01) were confirmed in black men.<h4>Conclusion</h4>These results suggest that a low-grade inflammatory state as reflected by both a conventional and novel marker of inflammation may contribute to higher cardiovascular risk as reflected by the associations obtained with a marker of cardiac strain in black South African men.Ruan KrugerRudolph SchutteHugo W HuismanPeter HinderssonMichael H OlsenJesper Eugen-OlsenAletta E SchuttePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e58506 (2013) |
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Medicine R Science Q Ruan Kruger Rudolph Schutte Hugo W Huisman Peter Hindersson Michael H Olsen Jesper Eugen-Olsen Aletta E Schutte NT-proBNP, C-reactive protein and soluble uPAR in a bi-ethnic male population: the SAfrEIC study. |
| description |
<h4>Objective and design</h4>This cross-sectional study aimed to investigate associations between a marker of cardiac strain, the N-terminal prohormone B-type natriuretic peptide (NT-proBNP), and inflammation as reflected by either a conventional or novel inflammatory marker in a bi-ethnic South African cohort.<h4>Methods and subjects</h4>We measured NT-proBNP, C-reactive protein (CRP) and plasma-soluble urokinase plasminogen activator receptor (suPAR) levels along with conventional biomarkers in black (n = 117) and white (n = 116) men.<h4>Results</h4>NT-proBNP, CRP and suPAR levels were higher in black compared to white men. NT-proBNP was significantly associated with both CRP (r = 0.38; p = 0.001) and suPAR (r = 0.42; p<0.001) in black men only. After full adjustment in multiple regression analyses, the above associations of NT-proBNP with CRP (β = 0.199; p = 0.018) and suPAR (β = 0.257; p<0.01) were confirmed in black men.<h4>Conclusion</h4>These results suggest that a low-grade inflammatory state as reflected by both a conventional and novel marker of inflammation may contribute to higher cardiovascular risk as reflected by the associations obtained with a marker of cardiac strain in black South African men. |
| format |
article |
| author |
Ruan Kruger Rudolph Schutte Hugo W Huisman Peter Hindersson Michael H Olsen Jesper Eugen-Olsen Aletta E Schutte |
| author_facet |
Ruan Kruger Rudolph Schutte Hugo W Huisman Peter Hindersson Michael H Olsen Jesper Eugen-Olsen Aletta E Schutte |
| author_sort |
Ruan Kruger |
| title |
NT-proBNP, C-reactive protein and soluble uPAR in a bi-ethnic male population: the SAfrEIC study. |
| title_short |
NT-proBNP, C-reactive protein and soluble uPAR in a bi-ethnic male population: the SAfrEIC study. |
| title_full |
NT-proBNP, C-reactive protein and soluble uPAR in a bi-ethnic male population: the SAfrEIC study. |
| title_fullStr |
NT-proBNP, C-reactive protein and soluble uPAR in a bi-ethnic male population: the SAfrEIC study. |
| title_full_unstemmed |
NT-proBNP, C-reactive protein and soluble uPAR in a bi-ethnic male population: the SAfrEIC study. |
| title_sort |
nt-probnp, c-reactive protein and soluble upar in a bi-ethnic male population: the safreic study. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/8d147cbfa05243be95459b2a683bbd7c |
| work_keys_str_mv |
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| _version_ |
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