Determinants of microdamage in elderly human vertebral trabecular bone.

Previous studies have shown that microdamage accumulates in bone as a result of physiological loading and occurs naturally in human trabecular bone. The purpose of this study was to determine the factors associated with pre-existing microdamage in human vertebral trabecular bone, namely age, archite...

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Autores principales:	Hélène Follet, Delphine Farlay, Yohann Bala, Stéphanie Viguet-Carrin, Evelyne Gineyts, Brigitte Burt-Pichat, Julien Wegrzyn, Pierre Delmas, Georges Boivin, Roland Chapurlat
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8d14f6977f34472ba80d41dab2acda04
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spelling	oai:doaj.org-article:8d14f6977f34472ba80d41dab2acda042021-11-18T07:57:23ZDeterminants of microdamage in elderly human vertebral trabecular bone.1932-620310.1371/journal.pone.0055232https://doaj.org/article/8d14f6977f34472ba80d41dab2acda042013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23457465/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Previous studies have shown that microdamage accumulates in bone as a result of physiological loading and occurs naturally in human trabecular bone. The purpose of this study was to determine the factors associated with pre-existing microdamage in human vertebral trabecular bone, namely age, architecture, hardness, mineral and organic matrix. Trabecular bone cores were collected from human L2 vertebrae (n = 53) from donors 54-95 years of age (22 men and 30 women, 1 unknown) and previous cited parameters were evaluated. Collagen cross-link content (PYD, DPD, PEN and % of collagen) was measured on surrounding trabecular bone. We found that determinants of microdamage were mostly the age of donors, architecture, mineral characteristics and mature enzymatic cross-links. Moreover, linear microcracks were mostly associated with the bone matrix characteristics whereas diffuse damage was associated with architecture. We conclude that linear and diffuse types of microdamage seemed to have different determinants, with age being critical for both types.Hélène FolletDelphine FarlayYohann BalaStéphanie Viguet-CarrinEvelyne GineytsBrigitte Burt-PichatJulien WegrzynPierre DelmasGeorges BoivinRoland ChapurlatPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e55232 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hélène Follet Delphine Farlay Yohann Bala Stéphanie Viguet-Carrin Evelyne Gineyts Brigitte Burt-Pichat Julien Wegrzyn Pierre Delmas Georges Boivin Roland Chapurlat Determinants of microdamage in elderly human vertebral trabecular bone.
description	Previous studies have shown that microdamage accumulates in bone as a result of physiological loading and occurs naturally in human trabecular bone. The purpose of this study was to determine the factors associated with pre-existing microdamage in human vertebral trabecular bone, namely age, architecture, hardness, mineral and organic matrix. Trabecular bone cores were collected from human L2 vertebrae (n = 53) from donors 54-95 years of age (22 men and 30 women, 1 unknown) and previous cited parameters were evaluated. Collagen cross-link content (PYD, DPD, PEN and % of collagen) was measured on surrounding trabecular bone. We found that determinants of microdamage were mostly the age of donors, architecture, mineral characteristics and mature enzymatic cross-links. Moreover, linear microcracks were mostly associated with the bone matrix characteristics whereas diffuse damage was associated with architecture. We conclude that linear and diffuse types of microdamage seemed to have different determinants, with age being critical for both types.
format	article
author	Hélène Follet Delphine Farlay Yohann Bala Stéphanie Viguet-Carrin Evelyne Gineyts Brigitte Burt-Pichat Julien Wegrzyn Pierre Delmas Georges Boivin Roland Chapurlat
author_facet	Hélène Follet Delphine Farlay Yohann Bala Stéphanie Viguet-Carrin Evelyne Gineyts Brigitte Burt-Pichat Julien Wegrzyn Pierre Delmas Georges Boivin Roland Chapurlat
author_sort	Hélène Follet
title	Determinants of microdamage in elderly human vertebral trabecular bone.
title_short	Determinants of microdamage in elderly human vertebral trabecular bone.
title_full	Determinants of microdamage in elderly human vertebral trabecular bone.
title_fullStr	Determinants of microdamage in elderly human vertebral trabecular bone.
title_full_unstemmed	Determinants of microdamage in elderly human vertebral trabecular bone.
title_sort	determinants of microdamage in elderly human vertebral trabecular bone.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/8d14f6977f34472ba80d41dab2acda04
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Determinants of microdamage in elderly human vertebral trabecular bone.

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