Synthetic energy sensor AMPfret deciphers adenylate-dependent AMPK activation mechanism

AMP-activated protein kinase AMPK senses and regulates cellular energy state. Here the authors engineer a synthetic sensor, AMPfret, that allows direct, real-time readout of the AMPK conformational state by fluorescence resonance energy transfer (FRET).

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Autores principales:	Martin Pelosse, Cécile Cottet-Rousselle, Cécile M. Bidan, Aurélie Dupont, Kapil Gupta, Imre Berger, Uwe Schlattner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8d15448cd9064472a9bb9937a9aad01a
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spelling	oai:doaj.org-article:8d15448cd9064472a9bb9937a9aad01a2021-12-02T14:39:41ZSynthetic energy sensor AMPfret deciphers adenylate-dependent AMPK activation mechanism10.1038/s41467-019-08938-z2041-1723https://doaj.org/article/8d15448cd9064472a9bb9937a9aad01a2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08938-zhttps://doaj.org/toc/2041-1723AMP-activated protein kinase AMPK senses and regulates cellular energy state. Here the authors engineer a synthetic sensor, AMPfret, that allows direct, real-time readout of the AMPK conformational state by fluorescence resonance energy transfer (FRET).Martin PelosseCécile Cottet-RousselleCécile M. BidanAurélie DupontKapil GuptaImre BergerUwe SchlattnerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin Pelosse Cécile Cottet-Rousselle Cécile M. Bidan Aurélie Dupont Kapil Gupta Imre Berger Uwe Schlattner Synthetic energy sensor AMPfret deciphers adenylate-dependent AMPK activation mechanism
description	AMP-activated protein kinase AMPK senses and regulates cellular energy state. Here the authors engineer a synthetic sensor, AMPfret, that allows direct, real-time readout of the AMPK conformational state by fluorescence resonance energy transfer (FRET).
format	article
author	Martin Pelosse Cécile Cottet-Rousselle Cécile M. Bidan Aurélie Dupont Kapil Gupta Imre Berger Uwe Schlattner
author_facet	Martin Pelosse Cécile Cottet-Rousselle Cécile M. Bidan Aurélie Dupont Kapil Gupta Imre Berger Uwe Schlattner
author_sort	Martin Pelosse
title	Synthetic energy sensor AMPfret deciphers adenylate-dependent AMPK activation mechanism
title_short	Synthetic energy sensor AMPfret deciphers adenylate-dependent AMPK activation mechanism
title_full	Synthetic energy sensor AMPfret deciphers adenylate-dependent AMPK activation mechanism
title_fullStr	Synthetic energy sensor AMPfret deciphers adenylate-dependent AMPK activation mechanism
title_full_unstemmed	Synthetic energy sensor AMPfret deciphers adenylate-dependent AMPK activation mechanism
title_sort	synthetic energy sensor ampfret deciphers adenylate-dependent ampk activation mechanism
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8d15448cd9064472a9bb9937a9aad01a
work_keys_str_mv	AT martinpelosse syntheticenergysensorampfretdeciphersadenylatedependentampkactivationmechanism AT cecilecottetrousselle syntheticenergysensorampfretdeciphersadenylatedependentampkactivationmechanism AT cecilembidan syntheticenergysensorampfretdeciphersadenylatedependentampkactivationmechanism AT aureliedupont syntheticenergysensorampfretdeciphersadenylatedependentampkactivationmechanism AT kapilgupta syntheticenergysensorampfretdeciphersadenylatedependentampkactivationmechanism AT imreberger syntheticenergysensorampfretdeciphersadenylatedependentampkactivationmechanism AT uweschlattner syntheticenergysensorampfretdeciphersadenylatedependentampkactivationmechanism
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Synthetic energy sensor AMPfret deciphers adenylate-dependent AMPK activation mechanism

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