The proliferation index of specific bone marrow cell compartments from myelodysplastic syndromes is associated with the diagnostic and patient outcome.

Myelodysplastic syndromes (MDS) are clonal stem cell disorders which frequently show a hypercellular dysplastic bone marrow (BM) associated with inefficient hematopoiesis and peripheral cytopenias due to increased apoptosis and maturation blockades. Currently, little is known about the role of cell...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sergio Matarraz, Cristina Teodosio, Carlos Fernandez, Manuel Albors, María Jara-Acevedo, Antonio López, María Gonzalez-Gonzalez, María Laura Gutierrez, Juan Flores-Montero, Carlos Cerveró, Marlies Pizarro-Perea, María Paz Garrastazul, Gonzalo Caballero, Oliver Gutierrez, Guy Daniel Mendez, Manuel González-Silva, Paula Laranjeira, Alberto Orfao
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8d16534208c346109b714cf3ec6d1c84
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8d16534208c346109b714cf3ec6d1c84
record_format	dspace
spelling	oai:doaj.org-article:8d16534208c346109b714cf3ec6d1c842021-11-18T07:06:50ZThe proliferation index of specific bone marrow cell compartments from myelodysplastic syndromes is associated with the diagnostic and patient outcome.1932-620310.1371/journal.pone.0044321https://doaj.org/article/8d16534208c346109b714cf3ec6d1c842012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22952954/?tool=EBIhttps://doaj.org/toc/1932-6203Myelodysplastic syndromes (MDS) are clonal stem cell disorders which frequently show a hypercellular dysplastic bone marrow (BM) associated with inefficient hematopoiesis and peripheral cytopenias due to increased apoptosis and maturation blockades. Currently, little is known about the role of cell proliferation in compensating for the BM failure syndrome and in determining patient outcome. Here, we analyzed the proliferation index (PI) of different compartments of BM hematopoietic cells in 106 MDS patients compared to both normal/reactive BM (n = 94) and acute myeloid leukemia (AML; n = 30 cases) using multiparameter flow cytometry. Our results show abnormally increased overall BM proliferation profiles in MDS which significantly differ between early/low-risk and advanced/high-risk cases. Early/low-risk patients showed increased proliferation of non-lymphoid CD34(+) precursors, maturing neutrophils and nucleated red blood cells (NRBC), while the PI of these compartments of BM precursors progressively fell below normal values towards AML levels in advanced/high-risk MDS. Decreased proliferation of non-lymphoid CD34(+) and NRBC precursors was significantly associated with adverse disease features, shorter overall survival (OS) and transformation to AML, both in the whole series and when low- and high-risk MDS patients were separately considered, the PI of NRBC emerging as the most powerful independent predictor for OS and progression to AML. In conclusion, assessment of the PI of NRBC, and potentially also of other compartments of BM precursors (e.g.: myeloid CD34(+) HPC), could significantly contribute to a better management of MDS.Sergio MatarrazCristina TeodosioCarlos FernandezManuel AlborsMaría Jara-AcevedoAntonio LópezMaría Gonzalez-GonzalezMaría Laura GutierrezJuan Flores-MonteroCarlos CerveróMarlies Pizarro-PereaMaría Paz GarrastazulGonzalo CaballeroOliver GutierrezGuy Daniel MendezManuel González-SilvaPaula LaranjeiraAlberto OrfaoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e44321 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sergio Matarraz Cristina Teodosio Carlos Fernandez Manuel Albors María Jara-Acevedo Antonio López María Gonzalez-Gonzalez María Laura Gutierrez Juan Flores-Montero Carlos Cerveró Marlies Pizarro-Perea María Paz Garrastazul Gonzalo Caballero Oliver Gutierrez Guy Daniel Mendez Manuel González-Silva Paula Laranjeira Alberto Orfao The proliferation index of specific bone marrow cell compartments from myelodysplastic syndromes is associated with the diagnostic and patient outcome.
description	Myelodysplastic syndromes (MDS) are clonal stem cell disorders which frequently show a hypercellular dysplastic bone marrow (BM) associated with inefficient hematopoiesis and peripheral cytopenias due to increased apoptosis and maturation blockades. Currently, little is known about the role of cell proliferation in compensating for the BM failure syndrome and in determining patient outcome. Here, we analyzed the proliferation index (PI) of different compartments of BM hematopoietic cells in 106 MDS patients compared to both normal/reactive BM (n = 94) and acute myeloid leukemia (AML; n = 30 cases) using multiparameter flow cytometry. Our results show abnormally increased overall BM proliferation profiles in MDS which significantly differ between early/low-risk and advanced/high-risk cases. Early/low-risk patients showed increased proliferation of non-lymphoid CD34(+) precursors, maturing neutrophils and nucleated red blood cells (NRBC), while the PI of these compartments of BM precursors progressively fell below normal values towards AML levels in advanced/high-risk MDS. Decreased proliferation of non-lymphoid CD34(+) and NRBC precursors was significantly associated with adverse disease features, shorter overall survival (OS) and transformation to AML, both in the whole series and when low- and high-risk MDS patients were separately considered, the PI of NRBC emerging as the most powerful independent predictor for OS and progression to AML. In conclusion, assessment of the PI of NRBC, and potentially also of other compartments of BM precursors (e.g.: myeloid CD34(+) HPC), could significantly contribute to a better management of MDS.
format	article
author	Sergio Matarraz Cristina Teodosio Carlos Fernandez Manuel Albors María Jara-Acevedo Antonio López María Gonzalez-Gonzalez María Laura Gutierrez Juan Flores-Montero Carlos Cerveró Marlies Pizarro-Perea María Paz Garrastazul Gonzalo Caballero Oliver Gutierrez Guy Daniel Mendez Manuel González-Silva Paula Laranjeira Alberto Orfao
author_facet	Sergio Matarraz Cristina Teodosio Carlos Fernandez Manuel Albors María Jara-Acevedo Antonio López María Gonzalez-Gonzalez María Laura Gutierrez Juan Flores-Montero Carlos Cerveró Marlies Pizarro-Perea María Paz Garrastazul Gonzalo Caballero Oliver Gutierrez Guy Daniel Mendez Manuel González-Silva Paula Laranjeira Alberto Orfao
author_sort	Sergio Matarraz
title	The proliferation index of specific bone marrow cell compartments from myelodysplastic syndromes is associated with the diagnostic and patient outcome.
title_short	The proliferation index of specific bone marrow cell compartments from myelodysplastic syndromes is associated with the diagnostic and patient outcome.
title_full	The proliferation index of specific bone marrow cell compartments from myelodysplastic syndromes is associated with the diagnostic and patient outcome.
title_fullStr	The proliferation index of specific bone marrow cell compartments from myelodysplastic syndromes is associated with the diagnostic and patient outcome.
title_full_unstemmed	The proliferation index of specific bone marrow cell compartments from myelodysplastic syndromes is associated with the diagnostic and patient outcome.
title_sort	proliferation index of specific bone marrow cell compartments from myelodysplastic syndromes is associated with the diagnostic and patient outcome.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/8d16534208c346109b714cf3ec6d1c84
work_keys_str_mv	AT sergiomatarraz theproliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT cristinateodosio theproliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT carlosfernandez theproliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT manuelalbors theproliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT mariajaraacevedo theproliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT antoniolopez theproliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT mariagonzalezgonzalez theproliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT marialauragutierrez theproliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT juanfloresmontero theproliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT carloscervero theproliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT marliespizarroperea theproliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT mariapazgarrastazul theproliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT gonzalocaballero theproliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT olivergutierrez theproliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT guydanielmendez theproliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT manuelgonzalezsilva theproliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT paulalaranjeira theproliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT albertoorfao theproliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT sergiomatarraz proliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT cristinateodosio proliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT carlosfernandez proliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT manuelalbors proliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT mariajaraacevedo proliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT antoniolopez proliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT mariagonzalezgonzalez proliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT marialauragutierrez proliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT juanfloresmontero proliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT carloscervero proliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT marliespizarroperea proliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT mariapazgarrastazul proliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT gonzalocaballero proliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT olivergutierrez proliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT guydanielmendez proliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT manuelgonzalezsilva proliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT paulalaranjeira proliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome AT albertoorfao proliferationindexofspecificbonemarrowcellcompartmentsfrommyelodysplasticsyndromesisassociatedwiththediagnosticandpatientoutcome
_version_	1718423927947001856

The proliferation index of specific bone marrow cell compartments from myelodysplastic syndromes is associated with the diagnostic and patient outcome.

Ejemplares similares