Efficacy of lovastatin on learning and memory deficits caused by chronic intermittent hypoxia-hypercapnia: through regulation of NR2B-containing NMDA receptor-ERK pathway.

Efficacy of lovastatin on learning and memory deficits caused by chronic intermittent hypoxia-hypercapnia: through regulation of NR2B-containing NMDA receptor-ERK pathway.

<h4>Background</h4>Chronic intermittent hypoxia-hypercapnia (CIHH) exposure leads to learnning and memory deficits in rats. Overactivation of N-methyl-D-aspartate receptors(NMDARs) can lead to the death of neurons through a process termed excitotoxicity, which is involved in CIHH-induced...

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Autores principales: Xin-long Huo, Jing-jing Min, Cai-yu Pan, Cui-cui Zhao, Lu-lu Pan, Fei-fei Gui, Lu Jin, Xiao-tong Wang
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/8d182ce2d8194ce2a9dab3cfc758ca7b
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